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In 1 capsule of naltrexone of a hydrochloride of 50 mg. Lactoses monohydrate, titanium dioxide, magnesium stearate, indigo carmine, gelatin as excipients.
Capsules of 50 mg.
Solution for intake of 50 mg / 10 ml and 100 mg / 20 ml.
Blockade of opiate receptors.
Pharmacodynamics and pharmacokinetics
Antagonist of opiates. Contacts opioid receptors and eliminates effect of opioids endogenous and exogenous (narcotic analgetics). Opiates cannot contact receptors and cannot cause opium intoxication.
In a dose of 50 mg blocks action of 25 mg of heroin or 5 l of vodka within a day. If the dose doubles, action to 48 h if trebles — till 72 o'clock. It is possible to weaken effect of active agent administration of opioids in high doses. Causes insignificant narrowing of a pupil. Does not cause physical or mental dependence.
At intake it is well absorbed and Cmax is defined in 1 hour. Gets through fabric barriers. About 95% of a dose biotransformirutsya in a liver and active metabolites are formed (the main of them 6 - beta naltreksol blocks opioids too). It is removed by the most part kidneys in the form of metabolites and only 1% of a dose in not changed look. An elimination half-life of naltrexone — 4 hours, his main metabolite — 13 hours. It is capable to kumulirovat.
Indications to use
As a part of complex therapy at:
- opioid dependence (after stopping of an abstinence syndrome);
- alcoholism (a maintenance therapy against psychotherapy).
- age till 18 flyings;
- positive test with Naloxonum;
- availability of opioids in urine;
- acute hepatitis;
- abstinence syndrome;
- liver failure;
- concomitant use of narcotic analgetics.
With care to apply at abnormal liver functions and kidneys.
The met side reactions are more often:
- sleep disorders;
- muscle pains and joint pains;
- nausea and vomiting;
- abdominal pains.
The met side reactions are more rare:
- loss of appetite;
- diarrhea or locks;
- psychomotor excitement;
- decrease in a potentiality;
- confusion of consciousness;
Antakson, application instruction (Way and dosage)
At heroin drug addiction treatment is begun in the absence of an abstinence syndrome and not earlier than a week after reception of narcotic substances (it is checked according to the analysis of urine for the content of opioids).
Treatment is begun only after negative provocative test with Naloxonum of 500 mkg in/in (shortly acting antagonist). Test is not carried out at an abstinence syndrome and also if in urine opioids are found. If test negative, is appointed prolonged treatment this drug. The first single dose — 20 mg of solution which is accepted inside. If within 1 hour there are no signs of a withdrawal give the remained 30 mg of solution. Next day appoint tablets Antakson of 50 mg which the patient drinks each 24 hours.
There are also other schemes of treatment at the discretion of the doctor — on 100 mg each 2 days or three times a week — Monday, Tuesday and Friday respectively 100 mg, 100 mg and 150 mg. The course of treatment has to make from 3 to 6 months.
At an alcoholism appoint daily 50 mg, a course 3 months and more.
If during this time surgical intervention with purpose of opioid analgetics is necessary to the patient, Antakson cancel in 48 hours prior to operation.
There are no data on a possibility of overdose. At suspicion on intoxication carry out a symptomatic treatment.
Efficiency of the medicines containing opioids (antidiarrheal, antibechic and opioid analgetics) decreases. At co-administration of gepatoksichny drugs the risk of damage of a liver increases.
Terms of sale
According to the recipe.
Temperature is up to 30 °C.
Period of validity
Coincidence on the ATH code of the 4th level:
More than 40 years this drug is used for treatment of drug-addicted patients. Antakson at alcoholism began to be applied a bit later. It is recommended to WHO for use in narcological practice. At a combination to psychotherapy at patients with high motivation it is possible to reach remission in 60–80% of cases.
According to patients, Antakson really weakens drug and alcohol addiction. Treatment with it was begun in a hospital after carrying out a course of a detoxication, stopping of an abstinence syndrome and elimination of somatic and mental disturbances. The course of treatment most often was 5-6 months.
Analyzing responses, it is possible to draw a conclusion that at 90% of patients in an initiation of treatment subdepressive frustration and alarming and sad mood remained. By the end of the third week of treatment asthenic frustration disappeared and the dream was normalized. However irascibility and irritability long remained. By the beginning of the 2nd month the state at all significantly improved. In most cases patients after an initiation of treatment stopped consuming alcohol at once. Some could not at once stop drinking and gradually reduced an alcohol dosage against treatment.
- "… I began a depression, but it is necessary to keep the doctor told that "the absolute sobriety" is necessary.
- "… Quite well inhibits desire to drink, but such alarm and irritability that I can break".
- "… Could not and broke after 10 days. There was a hard drinking and noticed that drug facilitates hard drinking course".
- "… The husband accepted. This means not only helps to bring out of hard drinking, but also is intended for treatment of alcoholism. Struggled with a disease of all family — went with the husband to the psychotherapist, created a favorable situation in a family and supported the husband. At first the amount of the drunk alcohol was reduced, then the frequency and weight of hard drinkings considerably decreased. Gradually achieved long remission — does not drink 1,5 years".
Today it is highly effective drug, one of the few which reduces inclinations to intoxication, allows to control behavior of patients and to prevent recurrence of diseases. It is possible to appoint him all patient irrespective of duration of an alcohol abuse and weight of a state. Does not cause accustoming even if it is long to accept and as it is compatible to other medicines, it increases efficiency of treatment.
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