Decarice

Декарис Drug photo

The description is actual on 11.04.2016

  • Latin name: Decaris
  • ATH code: P02CE01
  • Active ingredient: Levamisole (Levamisole)
  • Producer: Gedeon Richter (Hungary)

Structure

Levamisole hydrochloride, starch corn, sodium saccharinate, talc, povidone, fragrance apricot, magnesium stearate, dye yellow.

Release form

Tablets — flat, a round form, light orange color 50 and 150 of mg in the blister planimetric packaging No. 1 and 2 in a cardboard pack.

Pharmacological action

Protivogelmintnoye.

Pharmacodynamics and pharmacokinetics

Pharmacodynamics

Wikipedia defines Dekaris as the anthelmintic means possessing immunomodulatory action. Drug depolarizes muscular membranes of helminths, oppresses enzymatic activity of fumaratereductase and a succinatedehydrogenase, suppresses biopower processes. The paralyzed nematodes within a day after administration of drug are removed from an organism an intestines peristaltics.

Immunomodulatory effect of drug is shown by the strengthened development of antibodies on antigens and the T-cellular answer, activation of T lymphocytes, increase of function of macrophages, monocytes and neutrophils (phagocytosis, a chemotaxis and adhesion).

Pharmacokinetics

At intake drug is quickly soaked up from a gastrointestinal tract. Smakh in blood after administration of drug is reached in 1,5-2 hours. The metabolism of levamisole occurs in a liver, its metabolites are the glucuronide and hydroxy-levamisole. An elimination half-life — 3-6 hours. It is allocated in the form of metabolites with urine and a stake.

Indications to use

Infection with helminths (dochmiasis, ascaridosis, necatoriasis, trikhostrongilez, trichuriasis, strongyloidosis, enterobiosis, toxoplasmosis).

Contraindications

  • high sensitivity to drug;
  • the agranulocytosis in the anamnesis caused by medicines;
  • age till 3 flyings;
  • period of pregnancy and lactation.

To accept carefully at oppression of a marrowy hemopoiesis, a liver and renal failure.

Side effects

Sleeplessness, headache, dizziness, spasms, heart consciousness, encephalopathy, dispepsichesky frustration, skin rash, leukopenia, agranulocytosis, tremor.

Tablets Dekaris, application instruction (Way and dosage)

The adult to accept inside, during food in the following dosage:

  • At a toxoplasmosis: once at one time 150 mg a day within three days. If necessary the course of treatment can be repeated with breaks in one 1 week.
  • At helminthoses: once, before going to bed in a dose of 150 mg for adults and at the rate of 2.5 mg/kg for children. If necessary the course can repeatedly be repeated in 1-2 weeks.

The application instruction of Dekaris indicates the need researches of peripheral blood before an initiation of treatment, and during treatment – monitoring procedure of number of leukocytes. During administration of drug and later, for one days, it is strictly forbidden to take alcoholic drinks.

Overdose

At reception of a high dose of drug (more than 600 mg) there can be symptoms of intoxication in the form of nausea, vomitings, a headache, dizziness, drowsiness, a diarrhea, spasms and confusion of consciousness.

Interaction

Decarice cannot be accepted with ethanol, lipophilic connections (phenoxin, oil a henopodiya, tetrachlorethylene, chloroform) and the HP causing a leukopenia.

Drug strengthens effect of indirect anticoagulants and Phenytoinum.

Terms of sale

According to the recipe.

Storage conditions

At a temperature of 15-25 °C.

Period of validity

60 months.

Decarice for children

Decarice for children, considering considerable number of possible side effects at treatment of helminthosis, it is possible to accept only after consultation with the doctor. Tablets for children are issued in a dose of 50 mg of levamisole.

How to accept drug to children? One tablet (50 mg) is expected 10 kg of weight of the child. The instruction on drug contains calculation of a dosage for children. Approximate dosages to children from 3 to 6 years make 25-50 mg; from 6 to 10 — 50-75 mg; from 10 to 14 years — 75-100 mg. However, calculation of a dosage for the weight of the child is more exact and allows to reduce probability of emergence of side effects.

Decarice for immunity increase

For increase of immunity at children it is practically not used. There is a set of modern highly effective and rather safe immunomodulators which if necessary the doctor will appoint to your child. About Dekaris's reception at children in most cases positive. Judging by them, side effects at children arise less than at adults. It is probable this results from the fact that parents, giving Dekaris from worms to the child, strictly observe the drug dosage appointed by the doctor. In responses good antivermicular action of Dekaris, and convenience of a single dose is noted.

Analogs

Coincidence on the ATH code of the 4th level:

Dekaris's analogs on active ingredient — Levamisole. With similar medical action treat drugs: Pyrantelum, Vermoxum, Gelmintoks, Piperazin, Mebendazolum, Vorminum, Medamin, Biltritsid, Telmoks, Nemozol, Flowers of a tansy, Semyon of pumpkin and others.

Zdravzona

  • Decarice 50 of mg No. 2 tabletkigedeon Richter
  • Decarice 150 of mg No. 1 tabletkigedeon Richter

Drugstore of IFC

  • Decarice tbl 150 mg No. 1, Gedeon Richtervengriya
  • Decarice tbl 50 mg No. 2, Gedeon Richtervengriya
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Apteka24

  • Dekarisgedeon Richter (Hungary)
  • Dekarisgedeon Richter (Hungary)

Paniapteka

  • Decarice of the tab. of 150 mg No. 1 Gideon Richter
  • Decarice of the tab. of 150 mg No. 1 Gideon Richter

BIOSPHERE

  • Decarice of 150 mg No. 1 of table.
  • Decarice of 50 mg No. 2 of table.
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Section: Antiparasitic
in more detail

Education: Graduated from Sverdlovsk medical school (1968 - 1971) as "Paramedic". Graduated from the Donetsk medical institute (1975 - 1981) as "An epidemiologist, a hygienist". Passed postgraduate study in the Central scientific research institute of epidemiology Moscow (1986 - 1989). An academic degree – the candidate of medical sciences (degree is awarded in 1989, protection – the Central scientific research institute of epidemiology Moscow). Numerous advanced training courses are studied in epidemiology and infectious diseases.

Experience: Work as the manager of department of disinfection and sterilization of 1981 - 1992. Work as the manager of department of especially dangerous infections of 1992 - 2010. Teaching activity at Medical institute 2010 - 2013.

PAY ATTENTION! Information on drugs on the website is help generalizing, collected from public sources and can form the basis for making decision on use of medicines it is not aware of treatment. Before medicine use Dekaris surely consult with the attending physician.