Emend

Эменд Drug photo

The description is actual on 25.07.2016

  • Latin name: Emend
  • ATH code: A04AD12
  • Active ingredient: Aprepitant (Aprepitant)
  • Producer: MERCK SHARP & DOHME, Corp. (USA)

Structure

Aprepitant, hydroxypropyl cellulose, sodium lauryl sulfate, sucrose, the granulated microcrystallic cellulose, the micronized sodium lauryl sulfate, titanium dioxide, iron oxide, gelatin.

Release form

Capsules Emend of 125 mg gelatinous white color in the blister in cardboard packaging No. 1, 2, 4, 5, 10.

Pharmacological action

Antiemetic.

Pharmacodynamics and pharmacokinetics

Pharmacodynamics

Selectively acting highly affine antagonist of receptors of the Tax Code (neurokinin-1), substance P. Exerts impact on the emetic center, warns the vomiting caused by use of chemotherapeutic drugs. Emend gets into a brain where contacts a Tax Code receptors, stops the acute and delayed phases of the vomiting caused by Cisplatinum and at the same time strengthens antiemetic effect of dexamethasone and an ondansetron.

Pharmacokinetics

Drug is quickly soaked up from a gastrointestinal tract, Cmax in blood is reached in 3 hours. Bioavailability of drug — 60%, meal does not exert the expressed impact on bioavailability. High linkng with blood proteins (95%), gets through GEB. It Biotransformirutsya by means of oxidation in a liver. It is removed through intestines and kidneys in the form of metabolites.

Indications to use

As mono drug or in a combination with other antiemetic HP for the prevention of the acute and delayed phase of the vomiting caused by antineoplastic drugs of various degree of an emetogennost.

Contraindications

High sensitivity to drug, a concomitant use with Pimozidum, tsizapridy, terfenadiny, astemizoly, the expressed liver failure.

Side effects

Dizziness, headache, sneezing, pharyngitis, cough, nausea, food faddism, thirst, dryness in a mouth, dyspepsia, anorexia, a lock, abdominal distention, the increased perspiration and a photosensitivity, bradycardia, an itch, a mialgiya, a dysuria, muscular spasms, increased fatigue, drowsiness, hypostases, attacks of feeling of heat, a hyperglycemia.

Emend, application instruction (Way and dosage)

Emend accept inside without binding to meal. Capsules should be accepted for 3 days together with antagonists of serotoninovy receptors and GKS. The recommended dose Emend at the three-day scheme of reception makes 125 mg. In the first day to accept in one hour prior to administration of drugs of chemotherapeutic action. On the second and third day — 80 mg in the morning. The scheme of receptions depends on degree of an emetogennost of himiopreparat and is provided in tables to Emend's summary.

Overdose

Most of patients transfer drug well. The headache and drowsiness is seldom or never possible.

Interaction

Drug induces a metabolism of Tolbutamidum and warfarin. The Aprepitant does not exert the expressed impact on pharmacokinetics of drugs antagonists of 5HT3-receptors: granisetrona, gidrodolasetrona and ondansetrona.

The concomitant use with hormonal contraceptives reduces their efficiency. Joint reception with the drugs inductors CYP3A4 (Rifampinum), can lead to decrease in efficiency of Emend.

Terms of sale

Prescription issue.

Storage conditions

At a temperature up to 25 °C.

Period of validity

4 years.

Analogs

Coincidence on the ATH code of the 4th level:

With similar therapeutic action treat drugs: Emtron, Emetron, Emeset, Setronon, Tropisetron, Osetrin, Omstron, Ondansetron, Nawobang, Izotron, Zofran, Zofetron, Domiegang, Granitron and others.

About Emenda

Experience of use of drug for the purpose of prevention of nausea and stopping of the acute and delayed vomiting demonstrates that drug Emend possesses the expressed antiemitogenny properties that allows to use it as an effective antiemetic. Medicine is choice drug at appointment to the patient of antineoplastic chemotherapy.

Zdravzona

  • Emend of 80 mg No. 1 kapsulamerck Sharp & Dohme B.V.
  • Emend set 125 of mg No. 1 capsule + 80 mg No. 2 kapsulymerck Sharp & Dohme B.V.
  • Emend of 125 mg No. 1 kapsulamerck Sharp & Dohme B.V.
  • Emend in/in liof.dlya Preeg. solution for infusions of 150 mg No. 1 flakonmerk Sharp and Doum

Drugstore of IFC

  • Emend kaps set (125 mg No. 1+80mg No. 2), Merck Sharp & Dohmessha
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Apteka24

  • Emendmerck Sharp & Dohme Corp. (USA)
Section: Others
in more detail

Education: Graduated from Sverdlovsk medical school (1968 - 1971) as "Paramedic". Graduated from the Donetsk medical institute (1975 - 1981) as "An epidemiologist, a hygienist". Passed postgraduate study in the Central scientific research institute of epidemiology Moscow (1986 - 1989). An academic degree – the candidate of medical sciences (degree is awarded in 1989, protection – the Central scientific research institute of epidemiology Moscow). Numerous advanced training courses are studied in epidemiology and infectious diseases.

Experience: Work as the manager of department of disinfection and sterilization of 1981 - 1992. Work as the manager of department of especially dangerous infections of 1992 - 2010. Teaching activity at Medical institute 2010 - 2013.

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