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In 1 ampoule of 1% of solution — 50 mg of succinylcholine of chloride, in 1 ampoule of 2% of solution of 100 mg of active ingredient.
Solution of 1% and 2% in ampoules on 5 ml and 5% solution in ampoules on 2 ml.
Pharmacodynamics and pharmacokinetics
Depolyarizushchy muscle relaxant which mechanism of action consists in braking of a neuromuscular transmission. Interacts with N-holinoretseptorami and as acetylcholine causes depolarization of a postsynaptic membrane. But unlike acetylcholine does not collapse acetylcholinesterase and almost does not collapse in a synaptic gap. Causes permanent depolarization that leads to disturbance of transfer of an impulse and relaxation of muscles. At first eyelids, masseters, muscles of fingers of hands, legs, backs, then intercostal muscles and a diaphragm relax.
Differs from muscle relaxants of the prolonged action in short-term action which is necessary at short-term operations. Causes increase of intracranial pressure. Antikholinesterazny means do not suppress effect of succinylcholine, and increase of concentration of acetylcholine supports depolarization. Thus strengthen and extend effect of succinylcholine.
At intravenous administration begins to work in 30 sec. and action of 8-10 min. lasts, at in oil — in 2-4 min. and action at adults — 30 minutes and 21 minutes at children continues. The short duration of action is explained by fast destruction pseudo-cholinesterase — blood plasma enzyme to sincaline and a suktsinilmonokholin which are not pharmacological active. An elimination half-life — 90 seconds on condition of the normal level of cholinesterase.
It is removed by kidneys. At genetic insufficiency of enzyme, effect of drug can lasts to 2-5 h. Myorelaxation action is stopped transfusion of fresh blood as it contains pseudo-cholinesterase. Does not get through GEB, does not kumulirut.
Indications to use
- Short-term operations (reposition of bone fragments, reposition of dislocations);
- trachea intubation;
- carrying out endoscopic procedures (esophago - bronkho-, a tsistoskopiya);
- elimination of spasms at tetanus;
- for reduction of negative influence of narcotic substance at an anesthesia;
- for switching off of breath and for the purpose of transition to the managed breath.
- abnormal liver function;
- the lowered content of cholinesterase in plasma;
- the expressed hyperthermia;
- fluid lungs;
- children till 1 year.
With care it is appointed to children and teenagers, at a cachexia and the patient with a serious illness of a liver.
- Respiratory depression;
- postoperative muscle pains;
- heart arrhythmias;
- increase of the ABP;
- increase of intraocular pressure;
- spasm of bronchial tubes;
- the increased salivation.
Increase in time of muscle relaxation is noted at deficit of cholinesterase in blood serum.
Lysthenonum, application instruction (Way and dosage)
The drug Lysthenonum is administered intravenously or intramusculary.
At the dose of 0,1 mg/kg entered in/in relaxation of muscles without respiratory depression is noted. The dose of 0,2 mg/kg-1,0 mg/kg causes full relaxation of muscles of an abdominal wall and a thorax and an apnoea. 2,5 mg/kg of weight are intramusculary appointed.
To children it is applied only in extreme cases, and the dosage makes 1-2 mg/kg of weight at intravenous administration or 2,5 mg/kg of weight at intramuscular. Apply 0,1% or 0,2% to long infusion solution. Let's combine with Ringer's solution, isotonic solution, 5% a dextrose.
Overdose is shown by strengthening of expressiveness of side effects and an apnoea. Treatment consists in transfusion of whole blood, carrying out an artificial respiration. Transfer in a stage of "double blocking", and then purpose of a neostigmin is recommended.
Use of not depolarizing relaxants reduces previously side reactions of Lysthenonum, and introduction strengthens it effect of not depolarizing relaxants. Side reactions amplify when using a halothane and decrease at administration of atropine and thiopental.
Myorelaxation action amplifies antibiotics (aminoglycosides, Amphotericinum In), Propanididum, cyclopropane, quinidine, cholinesterase inhibitors, beta-blockers, Ajmalinum, cyclophosphamide, oxytocin, Thiophosphamidum, Cimetidinum, fenotiaziny, Metoclopramidum, oral contraceptives and drugs of lithium.
It is not desirable to apply inhalation anesthetics (a halothane, izofluran, enfluran, ether and metoksifluran) as it increases risk of a malignant hyperthermia and the neuromuscular block. Lysthenonum strengthens action of a digitalis. Infusion of whole blood weakens effect of succinylcholine.
Terms of sale
It is released according to the recipe for hospitals.
Temperature of storage is up to 2-8 °C.
Period of validity
Analogs of Lysthenonum
Coincidence on the ATH code of the 4th level:
Ditilin-A, Mio-relaksin, Succinylcholine chloride, Hlorsuktsillin.
There are no reviews of this drug as it is used by anesthesiologists at introduction of the patient to an anesthesia. The patient is not told most often what anesthetic and a muscle relaxant will be used during operation — it solves the anesthesiologist after conversation with the patient and clarification of associated diseases. Taking into account the volume of operation, age of the patient and contraindications this or that mirelaksiruyushchy drug is appointed. In this case such contraindications are the renal failure and glaucoma. From this it follows that drug cannot be used at ophthalmologic operations as raises intraocular tension and there is a threat of protrusion of covers during operation and an effluence of a vitreous.
The drug Lysthenonum is used only at planned not long operations (till 20 minutes) at the prepared patients and surely apply atropine to the prevention of bradycardia. In urgentny cases (operation at patients in a state of shock) at the low ABP and in the conditions of an anoxemia, a hypercapnia and bradycardia, succinylcholine can lead to a cardiac standstill. All these moments are considered by anesthesiologists. Doctors note that at use of this drug patients in the postoperative period often show complaints to muscular pains.
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