Nemozol

Немозол Drug photo

The description is actual on 04.08.2016

  • Latin name: Nemozole
  • ATH code: P02CA03
  • Active ingredient: Albendazol (Albendazole)
  • Producer: Ipca Laboratories (India)

Structure

Tablets Nemozol in p / about contain 0.4 g of an albendazol, corn starch, povidone-30, the purified talc, sodium lauryl sulfate, gelatin, silicon dioxide (in a colloid form), sodium of starch glikolit, marked - and propylparaben, magnesium stearate. Structure p / about: titanium dioxide, gidroksipropilmetiltsellyuloz, propylene glycol; methylene dichloride and isopropanol (evaporate when drying).

Chewable tablets Nemozol contain 0,4 g of an albendazol, corn starch, povidone-30, the purified talc, sodium lauryl sulfate, silicon dioxide (in a colloid form), gelatin, citric acid, methyl - and propylparaben, sodium of starch glikolit, aspartame, magnesium stearate, fragrances (pineapple/mint).

Nemozol albendazol is a part of suspension concentration of 20 mg/ml. Auxiliary components: MKTs, sodium carboxymethylcellulose, sorbitol solution, the benzoic and sorbic acids, glycerin (glitserol), potassium a hydrochloride, polysorbate-80, fragrances (ice cream essences / the mixed fruit aroma), the purified water.

Release form

  • tablets of 0.4 g (chewing and in p / about);
  • oral suspension of 100 mg / 5 ml.

Tablets are packaged in blister strip packagings on one, in each pack on one packaging. Suspension is issued in bottles of 20 ml.

Pharmacological action

Antiparasitic, anthelmintic.

Pharmacodynamics and pharmacokinetics

(Albendazole) which is contained in Nemozola albendazol is the antiparasitic possessing an extensive action spectrum.

The main mechanism of effect of substance is connected with its ability to suppress polymerization of protein beta tubulina.

It leads to the fact that in cells of an intestinal path of helminths activity of cytoplasmatic microtubular system is broken; the course of biochemical processes in organisms of parasites changes; in muscle cells of nematodes movement of secretory granules and other organellas is blocked.

The death of parasites is result of such influence.

It is most effective concerning larvae of tape-worms (a pork tapeworm and an echinococcus), and also concerning roundworms of Strongyloides stercolatis (ugriyets intestinal).

Pharmacokinetics

From a digestive tract substance is absorbed badly, in plasma in not changed look it is not found. It is characterized by low bioavailability (about 30%).

Increase of absorption and the size Cmax (by 5 times) is promoted by administration of drug along with greasy food.

Substance quickly is exposed to biotransformation in a liver. Primary metabolite (M1) is the albendazola sulphoxide which also possesses anthelmintic activity.

TCmax M1 varies ranging from 2 till 5 o'clock. In the state connected with proteins of plasma there are about 70% of an albendazol of sulphoxide. Substance is almost completely distributed on an organism; is defined in a liver, bile, urine, in cystous liquid and a wall of a cyst, cerebrospinal liquid.

In a liver of M1 sulphone (Sq.m) and other oxidized products turns into an albendazol. T1/2 M1 — from 8 to 12 hours. It is excreted by kidneys in the form of various products of a metabolism.

At a renal failure removal of an albendazol and M1 does not change.

At the broken function of a liver bioavailability of substance and Cmax M1 increase (twice), and also T1/2 is extended.

Albendazol promotes increase of activity of microsomal enzymes of the CYP system; accelerates a metabolism of many HP.

Indications to use

Drug is used for treatment:

  • nematodoses (ankilostomidoz, ascaridosis, trichuriasis, necatoriasis, enterobiosis);
  • strongyloidosis;
  • toksokaroza;
  • lambliasis;
  • neurocysticercosis which causative agent are larvae of the armed (pork) tapeworm;
  • echinococcosis of a peritoneum, lungs and a liver which activator are larvae of a tapeworm of an echinococcus;
  • the mixed helminthic invasions.

Also it is reasonable to use drug as addition to the main treatment at surgical interventions on removal of echinococcal cysts.

Contraindications

Nemozol's use is contraindicated at damages of a retina, hypersensitivity to any of tablets/suspension components, during pregnancy.

Relative contraindications:

  • disturbances of a hemogenesis;
  • liver dysfunction (to and during treatment regular control of a functional condition of body is necessary);
  • lactation.

Side effects

Side effects of drug can be shown in a look:

  • abnormal liver functions at which increase is noted (weak / moderately expressed)
  • activities of transaminases;
  • nausea/vomiting;
  • be ill in a stomach;
  • oppressions of a marrowy hemopoiesis (agranulocytosis, leukopenia, pancytopenia, granulocytopenia, thrombocytopenia);
  • dizzinesses;
  • headache;
  • clinical signs of irritation of covers of a brain (meningeal symptoms).
  • alopecias (reversible);
  • skin rash;
  • itch;
  • hyperthermia;
  • increases of the ABP;
  • hypersensitivity reactions;
  • acute renal failure.

Application instruction of Nemozol (Way and dosage)

Suspension Nemozol, application instruction

Medicine is taken inside during food. For increase of bioavailability of an albendazol it should be accepted with greasy food.

Nemozol for children of 12-24 months at an ascaridosis, a dochmiasis, a trichinosis, an enterobiosis, a necatoriasis is shown one-time reception of 1 dessertspoon of suspension (10 ml).

Recommendations how to accept to children are more senior than two-year age medicine, the following:

  • at an ascaridosis, a dochmiasis, a trichinosis, an enterobiosis, a necatoriasis — the child is once given 20 ml of drug (it is recommended to accept Nemozol from worms to at the same time all persons living together).
  • At a teniosis and a strongyloidosis for children 1 rubles/day on 20 ml for 3 days give suspension.
  • At a toksokaroza reception of 20 ml of suspension of 1 ruble/day for 10 days is shown.
  • At the polyhelminthoses caused by Clonorchis sinensis organism infection (a fluke Chinese) and Opisthorchis viverrini (a fluke of the Civet), it is recommended to give to patients twice a day within 3 days on 20 ml of suspension.

Treatment of a lambliasis at children aged from 2 till 12 flyings carry out 20 ml/days using a dose (medicine is taken at one time). The course lasts 5 days.

To adult patients Nemozol at a lambliasis, an ascaridosis, a dochmiasis, a strongyloidosis, a trichinosis, an enterobiosis, a necatoriasis, a toksokaroza, a teniosis and polyhelminthoses appoint to accept according to the similar scheme.

At a cystic/alveolar echinococcosis, and also at neurocysticercosis to patients whose weight more than 60 kg, drug is given twice a day on 20 ml. For patients, which weight less than 60 kg, the recommended daily dose of an albendazol — 15 mg/kg divided into 2 receptions. The highest dose — 800 mg/days.

The course of treatment at a cystic echinococcosis is expected 28 days. In 14 days treatment can be repeated. If necessary carrying out 3 courses is allowed.

At an alveolar echinococcosis to the patient appoint Nemozol's uses during 3 courses for 28 days with 14-tidnevny intervals between courses.

At neurocysticercosis treatment lasts from 1 week to 30 days. The repeated course is possible after 14 days.

At creeping rash suspension accept on 20 ml 1 rubles/day within 1-3 days.

Tablets Nemozol, application instruction

Pill is taken inside together with food (it is desirable greasy food as it allows to increase bioavailability of an albendazol).

For children is more senior than three-year age, teenagers and adults the following recommendations concerning that how to accept drug are provided in the instruction:

  • at an ascaridosis, a dochmiasis, a trichinosis, an enterobiosis, a necatoriasis — 1 tab. / days disposable.
  • At a teniosis and a strongyloidosis of a tablet give on one 1 rubles/day for 3 days.
  • At a toksokaroza a pill is taken on one 1 rubles/day for 10 days.
  • At the mixed helminthoses caused by Clonorchis sinensis organism infection (a fluke Chinese) and Opisthorchis viverrini (a fluke of the Civet), it is recommended to accept to patients twice a day within 3 days on one tablet.

For treatment of a lambliasis at adults and children is more senior than 3 years to the patient give on 1 tablet of Nemozol a day for 5 days.

At a cystic/alveolar echinococcosis, and also at neurocysticercosis to patients whose weight more than 60 kg, drug is given twice a day on 1 tablet. For patients, which weight less than 60 kg, the recommended daily dose of an albendazol — 15 mg/kg divided into 2 receptions. The highest dose — 800 mg/days.

The course of treatment at a cystic echinococcosis is expected 28 days. In 14 days treatment can be repeated. If necessary carrying out 3 courses is allowed.

At an alveolar echinococcosis to the patient appoint Nemozol's uses during 3 courses for 28 days with 14-tidnevny intervals between courses.

At neurocysticercosis treatment lasts from 1 week to 30 days. The repeated course is possible after 14 days.

At creeping rash a pill is taken on one in day within 1-3 days.

It is necessary to remember that tablets from worms are recommended to be drunk to at the same time all persons living together.

How Nemozol quickly acts?

About Nemozole for children and adults demonstrate that parasites after administration of drug leave usually within a week. In 3 weeks after carrying out treatment it is recommended to make retest a calla.

Overdose

At overdose the gastric lavage, reception of an enterosorbent (absorbent carbon) are shown to the patient and — if in it there is a need — a symptomatic treatment.

Interaction

Concentration of an active metabolite of an albendazol increases at simultaneous use of drug with Cimetidinum and Dexamethasone.

Terms of sale

According to the recipe.

Storage conditions

Irrespective of a release form drug has to be stored at a temperature to 25ºС in the place protected from moisture and light.

Period of validity

Three years.

Special instructions

During treatment by drug it is necessary to monitor changes of cellular composition of blood (level of leukocytes is checked prior to treatment and then each 2 weeks of a cycle) and activity of enzymes of a liver.

If Nemozol's use for the patient was resulted by a leukopenia, treatment has to be suspended. It is possible to continue a course only in that case if extent of decrease in concentration of neutrophils and leukocytes is insignificant, and the leukopenia does not progress.

If indicators of activity of liver enzymes exceed the upper bound of norm more than twice, stop Nemozol's use before their full normalization.

At neurocysticercosis drug is appointed in a combination with anticonvulsants and GKS. Peroral and the GKS parenteral forms on the first week of use of Nemozol are used for prevention of an attack of hypertensia.

Nemozol's analogs

Coincidence on the ATH code of the 4th level:

Structural analogs of Nemozol: Gelmodol-VM, Sanoksal, Albendazole.

Nemozol or Vermoxum — what is better?

Vermoxum is an antiparasitic of a broad spectrum of activity. The basis of drug is made by substance Mebendazolum, its concentration in one tablet — 100 mg.

Vermoxum is most effective at a trichuriasis and an enterobiosis. Nemozol shows the greatest activity concerning larvae of a pork tapeworm and an echinococcus, and also concerning an intestinal ugritsa.

Vermoxum can be applied from two-year age whereas suspension Nemozol to children is appointed since a year.

That it is better: Decarice or Nemozol?

Dekaris as active agent contains in tablets levamisole (50 or 150 mg / tab.). Levamisole is effective at infections with the following parasites:

  • Ancylostoma duodenale;
  • Ascaris lumbrocoides;
  • Necator Americanus.

Drug is allowed for use for patients is more senior than three-year age.

Zdravzona

  • Nemozol 100mg/5ml suspension for vnutr. uses 20mlipka Laboratoriz Limited
  • Nemozol of 400 mg No. 1 tablet of a p/oipk Laboratoriz Limited
  • Not callosity cream 5 of for removal of dry callosities
  • Not callosity cosmetic 15glaboratoriya Emansi of closed joint stock company
  • Nemozol of 400 mg No. 1 tablet of a zhevatelnayaipk Laboratoriz Limited

Drugstore of IFC

  • Nemozol susp. 100mg/5ml fl 20 ml, Ipcaindiya
  • Not callosity of Wednesday - in cosmetic 15 ml, Tvins of Energy industry Zaorossiya's closed joint stock company / Sagittarius
  • Nemozol tbl to chew. 400 mg No. 1, Ipcaindiya
  • Nemozol tbl p / about 400 mg No. 1, Ipcaindiya
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BIOSPHERE

  • Nemozol of 100 mg / 5 ml of 20 ml susp. for reception vnutripca Laboratories (India)
  • Nemozol of 400 mg No. 1 tabl.p.o.ipca Laboratories (India)
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Section: Antiparasitic
PAY ATTENTION! Information on drugs on the website is help generalizing, collected from public sources and can form the basis for making decision on use of medicines it is not aware of treatment. Before medicine use Nemozol surely consult with the attending physician.