Singlon

Синглон Drug photo

The description is actual on 19.07.2016

  • Latin name: Singlon
  • ATH code: R03DC03
  • Active ingredient: Montelukast (Montelukast)
  • Producer: Gedeon Richter Poland Co Ltd (Poland)

Structure

In 1 chewable tablet of montelukast of sodium of 5,20 mg. Mannitolum, MKTs, fragrance, croscarmellose sodium, aspartame, dye, magnesium stearate as excipients.

In 1 tablet in a cover of montelukast of sodium of 10,4 mg.

Release form

Tablets in a cover of 10 mg.

Chewable tablets of 4 mg and 5 mg.

Pharmacological action

Antibronkhokonstriktorny, antiinflammatory.

Pharmacodynamics and pharmacokinetics

Pharmacodynamics

Active ingredient is a blocker of leukotriene receptors (separate leukotrienes — mediators of an inflammation which maintains hyperreactivity of bronchial tubes at asthma). Administration of drug prevents excess formation of a secret in a gleam of bronchial tubes and swelled mucous. Reduces weight of bronchial asthma, frequency of attacks.

Broncholitic action is noted within a day. It is effective at patients at the easy course of bronchial asthma which is badly controlled by reception of one bronchodilators.

Pharmacokinetics

At intake it is completely soaked up and in 2-3 hours in blood the maximum concentration of active agent is defined. Bioavailability — 65-74%. For 99% contacts blood proteins. It is metabolized in a liver. It is removed with bile.

Indications to use

  • treatment of bronchial asthma;
  • prevention of aggravations OH;
  • prevention of a bronchospasm at physical effort;
  • combination of bronchial asthma with polipozy a nose and intolerance of ASK;
  • allergic rhinitis.

Contraindications

To apply strictly in a dosage according to age.

Side effects

Singlon, application instruction (Way and dosage)

Chewable tablets Singlon of 4 mg is recommended to children of 2-5 years — on 1 tablet in the evening, for 1 h before meal, every day in the evening.

To children at the age of 6-14 appoint Singlon 5 mg — on 1 tablet daily in the evening. The effect develops within a day. If drug is appointed in parallel with GKS, then it is impossible to replace them with this medicine sharply.

Singlon of 10 mg is intended to adults and children since 15. It is recommended to take one pill inside, irrespective of meal time, daily in the evening.

Overdose

Cases of overdose are not registered. At clinical trials patients accepted up to 200 mg/days in a dose is long (22 weeks) without the significant phenomena. Overdose cases at reception more than 1000 mg were noted.

Adverse manifestations in this case included drowsiness, thirst, vomiting, an abdominal pain, a headache, a mydriasis and a hyperactivity.

Interaction

Reception with the other drugs which are applied to treatment OH is possible. The recommended dose does not render significant effects on kinetics of theophylline, Prednisolonum, a terfenadin, peroral contraceptives, digoxin and warfarin. At phenobarbital reception concentration in plasma of active agent decreases by 40%. To be careful at simultaneous use with phenobarbital, Phenytoinum and rifampicin (inductors CYP 3A4).

Montelukast does not influence a metabolism of a paklitaksel, a repaglinid and a roziglitazon. It is not necessary to accept drug together with the other drugs containing montelukast.

Terms of sale

It is released according to the recipe.

Storage conditions

Temperature is up to 25 °C.

Period of validity

3 years.

Singlon's analogs

Coincidence on the ATH code of the 4th level:

Singulyar, Monkasta, Singuleks, Montelast, Ektalust, Monler.

About Singlon

It is necessary to remember that this drug is not intended for stopping of attacks of asthma. For this purpose there are other medicines. According to responses of the patients suffering OH and which began to accept Singlon against reception of glucocorticosteroids there was an opportunity to lower a dose of the last. However decrease it happened gradually and under control of the doctor.

Tablets Singlon have a different dosage and are intended for adults and children of different age. Safety of tablets for children till 2 flyings is not established. Singlon to children is recommended to apply in the form of chewable tablets that is convenient at this age category. Use of this means for children is alternative of reception of corticosteroids in low doses at treatment OH only of easy degree (it can be applied as monotherapy). But as means of monotherapy are not recommended at patients with OH moderately severe.

Drug was appointed to children not only at OH, but also at allergic rhinitis, frequent bronchitis with tendency to a bronkhoobstruktion. There are some responses.

  • "… To us the allergist appointed, very much helped. Began to be ill much less and without obstructive bronchitis".
  • "… The son has bronchial asthma. Singlon reduced quantity of attacks".
  • "… 3 courses for 4 months drank this drug. Helped and in a week attacks stopped, but upon termination of reception in 2 weeks everything returned, but in in easier form".
  • "… The son has asthma. Drank drug of 4 months. He does not rescue us from hormones. Attacks appear at each ORZ".
  • "… Attacks left almost completely, the daughter accepts it from April to October the third year".
  • "… We accept courses for 3 months in the fall, in the period of catarrhal diseases. Well helps".
  • "… The allergist appointed, we drink only 2 weeks and night cough passed, before cough disturbed constantly for 2 years at night".

In the most part of cases drug was transferred well.

Zdravzona

  • Singlon of 5 mg No. 28 of a tablet zhevatelnyegedeon Richter
  • Singlon of 10 mg No. 28 of a tablet p/ogedeon Richter
  • Singlon of 4 mg No. 28 of a tablet zhevatelnyegedeon Richter
  • Singlon of 5 mg No. 14 of a tablet zhevatelnyegedeon Richter
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Apteka24

  • Singlon
  • Singlon
  • Singlon

BIOSPHERE

  • Singlon of 5 mg No. 28 of the tab. zhev.
  • Singlon of 4 mg No. 28 of the tab. zhev.
  • Singlon of 10 mg No. 28 of the tab. zhev.
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Section: Others
in more detail

Education: Graduated from Sverdlovsk medical school (1968 - 1971) as "Paramedic". Graduated from the Donetsk medical institute (1975 - 1981) as "An epidemiologist, a hygienist". Passed postgraduate study in the Central scientific research institute of epidemiology Moscow (1986 - 1989). An academic degree – the candidate of medical sciences (degree is awarded in 1989, protection – the Central scientific research institute of epidemiology Moscow). Numerous advanced training courses are studied in epidemiology and infectious diseases.

Experience: Work as the manager of department of disinfection and sterilization of 1981 - 1992. Work as the manager of department of especially dangerous infections of 1992 - 2010. Teaching activity at Medical institute 2010 - 2013.

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