Cytochrome C

Цитохром С Drug photo

The description is actual on 08.07.2016

  • Latin name: Cytochrom C
  • ATH code: C01EB
  • Active ingredient: Cytochrome C (Cytochrome C)
  • Producer: LLC Samson Honey (Russia)

Structure

In 1 bottle of 10 mg of lyophilisate of cytochrome C.

In 4 ml of solution of 10 mg of active agent.

Release form

Solution in bottles on 4 ml / 10мг.

Lyophilisate of 10 mg in a bottle.

Eye drops of 0,25% in a bottle on 2 ml with a dropper.

Pharmacological action

Metabolic, eliminates a hypoxia of fabrics.

Pharmacodynamics and pharmacokinetics

Pharmacodynamics

The metabolic drug having anti-hypoxemic and trophic effect. This high-molecular connection is received extraction from tissue of a myocardium of pigs or cattle. On structure it is close to hemoglobin and plays the main role in oxidation-reduction processes in an organism. The mechanism of action is connected with presence at a molecule of iron upon which transition of their one state in another, reactions and exchange processes accelerate, the hypoxia of fabrics decreases.

Possesses high activity concerning the superoxide which is a strong oxidizer — cytochrome neutralizes oxygen radicals and work as "trap". The inhibition of oxygen radicals in lens matters in prevention of development of a cataract.

Pharmacokinetics

It is completely soaked up and gets into cells of all fabrics.

Role of system of P450 cytochrome in a human body

The metabolism of drugs in a liver occurs in two stages. The first stage of biotransformation occurs under the influence of P450 cytochrome, monooxygenases and cytochrome of S-reductase. As a result of oxidizing reactions polar groups and metabolites are formed. P450 cytochrome plays an important role in oxidizing processes as the system of cytochrome performs the most part of this work. This system is provided by proteins which begin a metabolism in a small bowel, but the most part occurs in a liver.

Isoenzymes of cytochrome are provided more, than 55 forms and everyone is capable to metabolize several drugs suitable it on structure. It creates a basis for interaction of the medicines which are at the same time coming to an organism and knowing it, it is possible to warn heavy side reactions of medicines. Here some examples of interaction of HP. Drugs which increase activity of enzymes are called stimulators. For example, rifampicin, carbamazepine, Phenytoinum — strong stimulators of system of cytochrome, and the drug accepted at the same time and which is metabolized this system will be quickly removed from an organism, without having the effect. Therefore, these drugs cannot be accepted together.

There is also other type of interaction when together with one medicine of people uses another — cytochrome inhibitor (for example, antidepressants, ketokonazol, ftorkhinolona, omeprazol, Cimetidinum, metronidazole, chloramphenicol and many others). At the same time its metabolism is slowed down, half-life increases, the risk of overdose and development of side reactions increases.

Indications to use

Solution for injections:

  • asphyxia of newborns;
  • poisonings with somnolent drugs, alcohol and drugs;
  • viral hepatitis with a hepatic coma;
  • ischemic and dystrophic damages of a myocardium;
  • bronchial asthma with respiratory insufficiency;
  • pneumonia;
  • chronic circulatory unefficiency;
  • severe injuries;
  • disturbances of cerebral circulation;
  • respiratory insufficiency;
  • thorax operations.

Eye drops:

  • cornea dystrophy;
  • keratitis;
  • opacification of a cornea.

Contraindications

  • Hypersensitivity to horse serum;
  • pregnancy;
  • breastfeeding;
  • age till 18 flyings.

With care it is appointed the patient having allergic diseases. They are recommended to carry out test.

Side effects

  • Dermahemia of the person (at fast introduction);
  • itch, urticaria;
  • hyperthermia;
  • fever.

At use of eye drops: short-term burning, conjunctiva hyperemia.

Cytochrome C, application instruction (Way and dosage)

The drug With is administered by Tsitokhr intravenously or intramusculary. Before use of drug it is necessary to check sensitivity to it. For this purpose vnutrikozhno enter 0,1 ml and wait for 30 minutes. In the absence of reaction (the small tortoiseshell, face reddening, an itch) it is possible to start injections. The dose makes 10-20 mg 1-2 times a day. Treatment is carried out by 14 days.

At heart failure — intravenously kapelno 20 mg within 6-8 hours, having parted in 200 ml of normal saline solution. The daily dose fluctuates from 30 mg to 80 mg.

During the period after heart operation — intravenously on 10 mg 2 times a day.

At a hepatic coma, shock, poisonings — 50-100 mg intravenously kapelno.

At asphyxia the newborn right after the birth enter 10 mg into an umbilical vein.

At bronchial asthma — intramusculary on 5-10 mg 2 times a day.

Before carrying out a repeated course take a bioassey.

Overdose

Data are absent.

Interaction

It is not described.

Terms of sale

It is released without recipe.

Storage conditions

Temperature of storage is 8 °C.

Period of validity

All forms — 2 years.

Analogs

Cyto — Mack.

About Tsitokhrom With

There are no reviews of this drug as it is used in complex treatment of hypoxemic states or for their prevention. Therefore it is not possible to draw a conclusion on efficiency of this drug. It is possible to trust experimental clinical trials only. So, for example, it is HP joined in an intensive care of the postoperative period to the patients who transferred prosthetics of valves of heart. Infusion drug in a dose of 0,5 g/kg was carried out before operation and repeatedly right after operation. The conclusion was drawn on its anti-hypoxemic and protivoishemshesky efficiency. It raises possibilities of a cardiac muscle in the conditions of ischemia, improves a coronary blood stream and sokratitelny function. It was an effective cardioprotector in surgery of "open heart".

Experience of use of this drug in the acute period of a myocardial infarction was repeatedly studied. Good results are available at intravenous administration of this drug (even one-time) in a dose of 50-100 mg at poisoning with carbon monoxide.

Antioxidant properties of drug are used at complex treatment of diabetic neuropathy, for normalization of gas exchange in the mother fruit system at fetoplacental insufficiency.

Section: Others
in more detail

Education: Graduated from Sverdlovsk medical school (1968 - 1971) as "Paramedic". Graduated from the Donetsk medical institute (1975 - 1981) as "An epidemiologist, a hygienist". Passed postgraduate study in the Central scientific research institute of epidemiology Moscow (1986 - 1989). An academic degree – the candidate of medical sciences (degree is awarded in 1989, protection – the Central scientific research institute of epidemiology Moscow). Numerous advanced training courses are studied in epidemiology and infectious diseases.

Experience: Work as the manager of department of disinfection and sterilization of 1981 - 1992. Work as the manager of department of especially dangerous infections of 1992 - 2010. Teaching activity at Medical institute 2010 - 2013.

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