Vermoxum

Вермокс Drug photo

The description is actual on 08.04.2016

  • Latin name: Vermox
  • ATH code: P02CA01
  • Active ingredient: Mebendazolum
  • Producer: Gedeon Richter Romania (Romania), Janssen Pharmaceutica (Belgium)

Structure

In 1 tablet of 100 mg of Mebendazolum.

Sodium lauryl sulfate, magnesium stearate, silicon dioxide, sodium saccharinate, starch, lactoses monohydrate, talc as excipients.

In 5 ml of suspension of 100 mg of a medendazol.

Release form

  • Suspension of 2%.
  • Tablets of 100 mg.

Pharmacological action

Anthelmintic.

Pharmacodynamics and pharmacokinetics

Pharmacodynamics

The anthelmintic drug having a broad spectrum of activity. High performance is noted at an enterobiosis, an ascaridosis and a trichuriasis. Mainly affects power processes of parasites. Causes disturbance of an expenditure of glucose, ATP synthesis, exhausts glycogen stocks. Selectively slows down synthesis of a β-tubulin of muscle cells of helminths that leads to their paralyzing and dysfunction of transport systems.

Perniciously affects eggs of ascarids, ankylostomas. In high doses it is applied to treatment of a trichinosis and an echinococcosis — abenteric helminthoses. Drug is well transferred.

Pharmacokinetics

Almost it is not soaked up in intestines. For 90% contacts blood proteins. Elimination half-life from 2,5 to 5 hours. Collects in larvae of helminths, a liver and fatty tissue. It is metabolized in a liver. About 5-10% of drug are soaked up and then removed by kidneys. More than 90% are allocated with a stake.

Indications to use

  • ankilostomidoz;
  • strongyloidosis;
  • enterobiosis;
  • ascaridosis;
  • trichuriasis;
  • teniosis;
  • trichinosis;
  • alveococcosis;
  • echinococcosis;
  • kapillyarioz;
  • the mixed helminthoses.

Contraindications

  • liver failure;
  • ulcer colitis;
  • hypersensitivity;
  • age till 2 flyings;
  • illness Krone;
  • pregnancy and feeding by a breast.

Side effects

  • abdominal pains;
  • dizziness;
  • nausea.

At use of high doses it is long:

  • vomiting, frustration of a chair;
  • headache;
  • rash, Quincke's edema;
  • hair loss;
  • increase of level of creatinine;
  • hamaturia and cylindruria;
  • increase of activity of enzymes of a liver;
  • leukopenia, eosinophilia, anemia.

Tablets Vermoxum, application instruction (Way and dosage)

Pill is taken inside. How to accept Vermoxum: to or after food? A pill is taken after food.

To adults and children since 10 at the revealed enterobiosis appoint once 100 mg. To children from 2 to 5 years of 25 mg also once, from 5 to 10 flyings of 50 mg once. Treatment of all family members is carried out. At high probability of a reinfestation — repeatedly in 2 weeks in a former dosage.

At an ascaridosis, an ankilostomidoza, a teniosis, a trichuriasis, a strongyloidosis or the mixed helminthoses accept twice a day 100 mg 3 days in a row.

At a trichinosis three times a day on 200-400 mg 3 days in a row, about 4 days increase a dose on 400-500 mg three times a day and accept till 10th day.

The application instruction of Vermoxum contains the warning that days after reception of tablets it is impossible to take alcohol, greasy food, to accept laxative. After the end of treatment it is necessary to investigate within 7 days smears and kcal on availability of helminths and their eggs. At prolonged treatment it is necessary to control function of a liver and kidneys, blood test.

Overdose

It is shown by symptoms: abdominal pains, nausea, diarrhea, vomiting.

At treatment by high doses it is long hepatitis, passing abnormal liver functions, a neutropenia are noted.

Treatment begins with a gastric lavage, reception of sorbents, carrying out symptomatic therapy if necessary.

Interaction

The concomitant use of Cimetidinum increases concentration of Mebendazolum in blood, lowers Carbamazepine.

Mebendazolum reduces need for insulin at a diabetes mellitus.

To avoid co-administration of lipophilic substances.

Terms of sale

According to the recipe.

Storage conditions

At a temperature no more than 30 Pages.

Period of validity

5 years.

Vermoxum for children

The most widespread diseases at children an ascaridosis, an enterobiosis and a lambliasis. Peaks of these parasitic diseases fall on 2-3 years, 4-7 years and 10-14 years that is connected with enzymatic insufficiency, disturbance of an acid-base gradient in departments of a gastrointestinal tract, normal microflora and motility. The period after intestinal infections at children, and also after an antibioticotherapia is more vulnerable concerning invasions.
At an ascaridosis efficiency of drug makes 100%. Vermoxum is applied to children in age doses: 2 — 10 years accept 0,05 g/days, having divided into 3 receptions, since 10 — 0,1 g a day for 3 receptions. Treatment is carried out by 3 days.

At an enterobiosis (infection with pinworms) treatment spend one day: from 2 to 5 years 1/4 tablets once, from 5 to 10 years 1/2 tablets, are more senior than 10 years 1 tablet. Repeated administration of drug in the same dose in 2 weeks is obligatory. It is also recommended to stretch linen at high temperature (90C) of all family members

How there are worms? They perish and next day in Calais it is possible to notice the immobilized parasites. The helminthic invasion causes functional digestive disturbances, change of a microbiocenosis and a fermentopatiya in children. In this connection after a deworming course to children appoint rates of fermental drugs and sinbiotik (Bifiform, Normoflorin) polyvitamins. Such complex treatment prevents emergence of organic pathology of a gastrointestinal tract and warns a reinfestation.
About drug positive — it seldom caused side effects. Some children had dispepsichesky phenomena, pains in a stomach, a headache. Also the skin aggravation of symptoms at children with dermatitis was noted. This results from the fact that the death of helminths is followed by release of toxins. For this reason enterosorbents in 2 hours after administration of drug are appointed in parallel. During treatment it is necessary to monitor also timely bowel emptying. At a lock intoxication caused by death of parasites, especially at an intensive glisty invasion amplifies. If there is no natural emptying it is necessary to give an enema.

Many parents give this drug to children for the purpose of prevention at the end of flying after rest at the dacha or in the village at grandmothers when infection at the use of dirty vegetables and fruit is the most probable, through dirty hands and after contact with animals. Whether it is justified? If the child has no complaints, nothing should be given for prevention. In certain cases purpose of helminthicides is justified, even without inspection. But not for the purpose of prevention and when there is a clinical symptomatology characteristic of this or that invasion, and laboratory is not confirmed. It is better not to self-medicate. The correct approach — at first laboratory research, even if 10 times, and then treatment which differs in terms and the choice of drug depending on a species of a parasite.

It is necessary to know that drug causes the increased physical activity of helminths, sometimes it leads to an antiperistalsis, vomiting and throwing of ascarids in respiratory tracts. Therefore at an intensive invasion at children it has to be applied with care.

Analogs

Coincidence on the ATH code of the 4th level:

Analogs Vorminum, Vero-Mebendazol, Vermakar, Mebeks, Mebendazolum, Telmoks 100.

Zdravzona

  • Vermoxum of 100 mg No. 6 tabletkigedeon Richter

Drugstore of IFC

  • Vermoxum tbl 100 mg No. 6, Gedeon Richtervengriya
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Apteka24

  • Vermoksjanssen-Cilag (Italy)
  • Vermoksgedeon Richter Romania (Romania)

Paniapteka

  • Vermoxum of the tab. of 100 mg No. 6yanssen-Silag

BIOSPHERE

  • Vermoxum of 100 mg No. 6 of table.
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Section: Antiparasitic
in more detail

Education: Graduated from Sverdlovsk medical school (1968 - 1971) as "Paramedic". Graduated from the Donetsk medical institute (1975 - 1981) as "An epidemiologist, a hygienist". Passed postgraduate study in the Central scientific research institute of epidemiology Moscow (1986 - 1989). An academic degree – the candidate of medical sciences (degree is awarded in 1989, protection – the Central scientific research institute of epidemiology Moscow). Numerous advanced training courses are studied in epidemiology and infectious diseases.

Experience: Work as the manager of department of disinfection and sterilization of 1981 - 1992. Work as the manager of department of especially dangerous infections of 1992 - 2010. Teaching activity at Medical institute 2010 - 2013.

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