Адеметионин Constitutional formula

The description is actual on 14.12.2015

  • Latin name: Adamethioninum
  • ATH code: A16AA02
  • Chemical formula: C15H22N6O5S
  • CAS code: 29908-03-0

Chemical name

(S)-5 ′-[(3-amino-3-carboxypropyl) metilsulfonio] - 5-dezoksiadenozin hydroxide (internal salt), (also in the form of a di-p-toluene sulphonate disulphate)

Chemical properties

Ademetionin – S-adenozilmetionin, the coenzyme which is taking part in reactions of transfer of methyl groups on an organism. This substance for the first time was described in the fifties the 20th centuries by the Italian scientist Kantoni. According to Wikipedia means has molecular weight = 399,5 grams on mol. Normal enzyme is formed by means of an adenoziltransferaza of ATP and methionine in liver tissues.

In a methionine molecule structure the methyl group joins sulfur atom, and as a part of S-adenozilmetionina it actively participates in reactions of chemical interaction. In the course of course more than 40 metabolic reactions happen transfer from CH3 group on proteins, nucleic acids, fats and other substrates.

This chemical compound is applied most often in the form of the lyophilized powder of white color to injections. At parenteral administration medicine possesses bigger biological availability in comparison with the tableted form. After reception of tablets only 5% of active ingredient are acquired. For intake use a disulphate, tosylate, butadeinsulfonat, the disulphate monozitat etc.

Pharmacological action

Detoksitsiruyushchy, gepatoprotektivny, neuroprotective, antioxidant, antidepressive.

Pharmacodynamics and pharmacokinetics

Synthetic Ademetionin fills shortage of a coenzyme in an organism, stimulating its development in tissues of a brain and liver. Substance tints CH3 group in reactions of methylation of cellular membranes, hormones, neuromediators and cellular proteins. The chemical compound is a predecessor of taurine, KOA, cysteine, glutathione and other thiol connections, spermine, a putrestsin, spermidine.

Substance possesses anti-cholestatic action. Drugs on the basis of this component eliminate a cholestasia, stimulate recovery of normal current of bile. There is it thanks to its ability to increase mobility and extent of polarization of membranes of hepatocytes, stimulating in them phosphatidylsincaline synthesis.

Also Ademetionin accelerates processes of a detoxication of ZhK, increases the level of the conjugated and sulphated fatty acids. Hepatocytes are easier brought with bile out of kidneys. The sulphated fatty acids are capable to protect liver cells from toxic influence of not sulphated ZhK.

The antidepressive effect of use of medicine comes within the first week of treatment and is stabilized during the next 14 days. Substance is rather effective at a neurotic and recurrent endogenous depression, as a prophylactic.

At cirrhosis or hepatitis of a liver, with a syndrome of an intracranial cholestasia medicine removes a skin itch, normalizes biochemical indicators of blood (bilirubin, aminotransferases, ShchF etc.). At a half of patients the asthenic syndrome disappears or considerably its intensity decreases. The effect of treatment remains within 3 months. Also means is rather effective at the raised load of a liver, owing to drug intake, at opioid addicts.

Substance showed sufficient efficiency at treatment of osteoarthrites with a pronounced pain syndrome. There is a stimulation of synthesis of proteoglycans and recovery of cartilaginous tissue.

Indications to use

Medicine is appointed:

  • at fatty dystrophy of a liver;
  • to patients with chronic hepatitis and toxic defeats of tissues of liver of various origin (from alcohol, viruses, drugs);
  • at chronic acalculous cholecystitis;
  • sick cirrhosis;
  • at a cholangitis or the encephalopathy including caused by a liver failure;
  • to pregnant women at an intracranial cholestasia;
  • for treatment of an abstinence syndrome as a part of complex therapy;
  • at a depression in combination with other drugs, for prevention of depressive episodes.


Drugs with Ademetionin are contraindicated:

  • at genetic disorders which exert impact on course of a metioninovy cycle;
  • to patients with a homocystinuria or a gipergomotsisteinemiya;
  • to children and teenagers;
  • at an allergy to active ingredient;
  • on 1 and 2 trimesters of pregnancy.

Side effects

During treatment by drug often develop:

Can be shown less often:

  • xerostomia, esophagitis, the increased gas generation, bleedings from a gastrointestinal tract, hepatic gripes;
  • disturbance of a sleep pattern, confusion of consciousness, headaches, paresthesias, dizziness;
  • pains and myotonia, arthralgias, infections of the urinogenital sphere;
  • enanthesis, perspiration, itch and xeroderma;
  • reactions in a substance injection site, up to a skin necrosis;
  • anaphylaxis, throat hypostasis, Quincke's edema;
  • adynamy, puffiness, fever, general weakness, hyperthermia, inflow.

With a bipolar depression medicine can cause inversion of affect (mania) in patients.

Ademetionin, application instruction (Way and dosage)

Drug is appointed inside, intramusculary or intravenously.

Tablets do not divide and do not chew, drink between meals, it is the best of all till a lunch. The recommended daily dosage makes 0,8-1,6 grams. Treatment by tablets can be made within 2 months, depending on indications and recommendations of the attending physician.

The instruction for Ademetionin, intravenous and intramuscular administration

Lyophilisate for injections is carefully dissolved in in advance prepared solvent (lysine solution is most often applied). The injection is made slowly, during the acute period (the first 14-21 day of an illness). About 0,4-0,8 grams of substance are recommended to enter. After achievement of resistant result and transfer of the patient from a hospital it is better to pass to the tableted medicine form.

The weakened or elderly patients are recommended to begin treatment with minimum active and effective doses.


Overdose by medicine is improbable, cases is not registered.


Ademetionin's combination with klomipraminy can lead to development of a serotoninovy syndrome.

With extra care combine medicine with selective serotonin reuptake inhibitors, tryptophane, tricyclic antidepressants.

Terms of sale

The recipe is necessary.

Storage conditions

Drug is stored in the dry place, at a temperature not above 25 degrees Celsius, far from small children.

Period of validity

2 years.

Special instructions

Considering that medicine has a certain tonic effect, it cannot be accepted before withdrawal to a dream.

Therapy by means needs to be carried out under supervision of the doctor. Throughout passing of a rate of drug it is necessary to determine the level of creatinine and urea in urine, nitrogen level in blood.

If in an organism there is a deficit of folic acid or B12 vitamin, then treatment can be insufficiently effective. It is recommended to accept these drugs in parallel.

As medicine can cause dizziness, during treatment it is impossible to steer the car or to carry out potentially life-threatening types of activity.

To children

This substance is contraindicated to reception aged till 18 flyings.

Structural analogs of Ademetionin (synonyms): Geptor, Geptral, Geptor N.


Some About use of this substance:

  • "… After passing of the medical commission to the husband advised to treat a liver and appointed infusions of this drug. Medicine is expensive, but efficient, after hospital the husband still spent on drink a course of tablets. Now analyses are normal, the condition of skin improved, the white plaque left language, side reactions during treatment were not";
  • " … Accepted means when problems with a liver began. From side reactions – having constantly felt thirsty, heartburn was during treatment tablets. I am very happy with result, though medicine was expensive";
  • " … A few years ago treated with its help stones in a gall bladder. In parallel the doctor appointed medicinal herbs and vitamins. But, unfortunately already in a week of drug intake, began to feel weight in a waist, creatinine level grew, was forced to stop treatment".
Section: Active ingredients
PAY ATTENTION! Information on active ingredients on the website is help generalizing, collected from public sources and can form the basis for making decision on use of these substances it is not aware of treatment. Before substance use Ademetionin surely consult with the attending physician.