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In 1 tablet of a paroksetin of a hydrochloride of 0,0228 g.
Calcium phosphate, starch, magnesium stearate, titanium dioxide, sodium carboxymethylstarch, an oksipropilmetiltsellyuloz, povidone, talc, polysorbate, - as excipients.
Tablets in a cover on 20 mg.
Pharmacodynamics and pharmacokinetics
Antidepressant, selektivno overwhelming return serotonin reuptake by a presynaptic membrane in this connection the quantity of this neuromediator increases and amplifies serotonergic action in TsNS. Action is shown in elimination of alarm and a depression and shown in 7–14 days. Does not influence napsikhomotorny functions, does not strengthen oppressing effect of ethanol.
When carrying out EEG by the patient accepting drug insignificant activation of TsNS is revealed. Does not cause the expressed change of the ABP and ChSS in healthy faces.
At intake it is well absorbed. Cmax in blood is defined by 5,2 h. In 7–14 days of daily reception of 30 mg of drug a day equilibrium concentration in blood is reached. For 95% contacts proteins. It is metabolized in a liver to inactive metabolites. It is removed by kidneys (64%) and through a gastrointestinal tract (36%). T1/2 makes 21 hour.
Indications to use
- all types of depressions, including against alcohol addiction;
- panic frustration (incidental);
- bipolar affective disorders;
- social phobia;
- persuasive states;
- alarming and phobic frustration;
- nervous anorexia and bulimia;
- posttraumatic stressful frustration.
- unstable epilepsy;
- reception with MAO inhibitors and after their cancellation (2 weeks);
- pregnancy and feeding by a breast;
- hypersensitivity to drug;
- children's age.
Side effects of Adepress
More often meeting:
- drowsiness or sleeplessness, tremor, dizziness, asthenic syndrome, alarm;
- orthostatic hypotension;
- loss of appetite, nausea, vomiting, locks or diarrhea, dryness in a mouth;
- the speeded-up urination;
- disturbance of an ejaculation and frustration of a libido.
The side effects which are found seldom:
- confusion of consciousness, paresthesia, hallucination, extrapyramidal frustration;
- myasthenia, arthralgia, mialgiya;
- galactorrhoea, anorgazmiya;
- rash, urticaria, itch, Quincke's disease;
- spasms, serotoninovy syndrome, panic frustration;
- expansion of pupils, vision disorder.
Application instruction of Adepress (Way and dosage)
Pill is taken inside, without chewing, during food, morning of 1 times a day.
The first two weeks the dose is selected and adjusted individually — increases by 10 mg weekly before receiving treatment of effect. The daily dose cannot exceed 60 mg, and for elderly patients of 40 mg.
The effect from lecheniyarazvivatsya gradually. For prevention of recurrence of Adepress appoint in a maintenance dose till 4-6 months and more.
The application instruction of Adepress contains the warning that at sharp drug withdrawal development of a withdrawal in this connection, the termination of reception is carried out gradually is possible. The first weeks of treatment emergence of suicide bents is possible.
At elderly people the hyponatremia is noted during therapy by drug.
Overdose is shown by nausea, vomiting, dryness in a mouth, expansion of pupils, a tremor, irritability.
Treatment is begun with provocation of vomiting or a gastric lavage, appoint absorbent carbon and symptomatic therapy.
Adepress at simultaneous use with Tryptophane causes the "serotoninovy syndrome" which is shown uneasiness, agitation, diarrhea.
It is incompatible with MAO inhibitors, it is necessary to observe an interval in purpose of these drugs. Increases concentration in blood of antiparkinsonichesky drug of Protsiklidin.
At reception with indirect anticoagulants increases a bleeding time.
Terms of sale
According to the recipe.
At a temperature no more than 25 °C.
Period of validity
Coincidence on the ATH code of the 4th level:
The reason of depressions, alarms and panic attacks is insufficient activity of GAMK-ergichesky system or the reduced maintenance of GAMK. Choice drugs in such cases are inhibitors of the return serotonin reuptake, one of them — Paroksetin (Adepress).
Responses of doctors are reduced to the fact that Paroksetin is an antidepressant of new generation, works selektivno and does not cause accustoming, has wide indications to use, combines high medical effect with safety of use.
From all group of these drugs Paroksetin is the strongest and most specific blocker of serotonin reuptake. Possesses more balanced action, and its advantage is an opportunity to apply on an outpatient basis at persons with neurologic and somatic pathology. It is drug of double action — is applied to treatment of alarm and a depression and eliminates wider range of symptoms at these states. Besides, its action is shown by the moderate stimulating effect.
Looking through About Adepresse at forums, it is possible to draw a conclusion that drug at correctly picked up dose improves a condition of patients after the first week of treatment. It was effective at patients who had no effect of the previous treatment. Reception of tablets does not exert impact on dream duration in the morning. All note convenience of use (1 times a day) that is important for the patients receiving the supporting out-patient treatment. Patients note good tolerance even at a long maintenance therapy. Undesirable side reactions meet seldom and are slightly expressed.
Isolated cases of emergence of a headache, dryness in a mouth and decrease in the ABP met at a trunk postural change.
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Section: For a nervous system
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