Akkuzid

Аккузид Drug photo

The description is actual on 06.07.2016

  • Latin name: Accuzide
  • ATH code: C09BA06
  • Active ingredient: Hydrochlorothiazide + Hinapril (Hydrochlorothiazide + Quinapril)
  • Producer: Goedecke GmbH Pfizer Group (Germany)

Structure

Hinaprila hydrochloride, hydrochlorothiazide, monohydrate of lactose, magnesium carbonate, krospovidon, povidone, ferrous oxide, magnesium stearate, titanium dioxide, opadray, macrogoal, wax.

Release form

Tablets, coated biconvex, pink color, a triangular (round) shape in the blister packaging in a cardboard pack No. 30.

Pharmacological action

Hypotensive, diuretic.

Pharmacodynamics and pharmacokinetics

Pharmacodynamics

The combined drug with anti-hypertensive effect which structure included two active ingredients: hinaprit (APF inhibitor) and a hydrochlorothiazide (diuretic) in three combinations of dosages.

Hinapril – the catalyst of synthesis of angiotensin II which due to stimulation of bark of adrenal glands (development of Aldosteronum), influences a tone of vessels and has vasoconstrictive effect. Hinapril inhibits APF (fabric and circulating) and reduces angiotonic activity and allocation of Aldosteronum. Stopping negative impact of angiotensin II on development of a renin, leads to strengthening of activity of a renin.

Decrease in the ABP happens against reduction of vascular resistance of kidneys and OPSS, at the same time, change of cordial emission, ChSS, a glomerular filtration rate and a renal blood-groove are insignificant or in general are absent. Hinapril slightly reduces the potassium loss caused by action of a hydrochlorothiazide which having diuretic effect, increases activity of a renin of blood, strengthens secretion of Aldosteronum, increases the content of potassium in blood and increases its renal elimination. Anti-hypertensive action develops for one hour and reaches a maximum in 3 hours, continuing for days.

The hydrochlorothiazide – belongs to group of diuretics, influences function of kidneys, strengthening removal of sodium, potassium, chlorides, bicarbonate ions and water and reducing at the same time calcium removal. Diuretic action is shown in 2 hours, the maximum effect — in 4 hours and its duration makes 6-12 hours.

Combinations of actively active ingredients (hinapril and hydrochlorothiazide) are provided more expressed to decrease in the ABP, than by action of each of them separately.

Pharmacokinetics

Both active ingredients at each other do not render influence.

Hinapril — Cmax is reached in 2 hours. Extent of absorption about 60%. High communication with blood proteins. In a liver it biotransformirutsya to the hinaprilat which is the APF strong inhibitor. Do not get through GEB. It is removed mainly through kidneys, T1/2 — about 3 hours.

The hydrochlorothiazide — possesses slower absorption, extent of absorption of 50-80%. Cmax is reached in 1-3 hours. Do not get through GEB. In an organism it is not metabolized, removed in an invariable look through kidneys. T1/2 — from 4 to 15 hours.

Indications to use

In a combination therapy of arterial hypertension at patients who have indications to purpose of a hinapril and hydrochlorothiazide.

Contraindications

Side effects

Dizziness, headache, unproductive cough most often occur among side effects at reception of any combinations of a hydrochlorothiazide and hinapril. The adynamy, a hyperexcitability, tachycardia, heartbeat, hypotension, a faint, anaphylactic reactions, nausea, dryness in a throat, locks/diarrhea, pancreatitis, a meteorism, hepatitis, an itch and skin rash, an arthralgia, peripheral hypostases, an alopecia are much less often noted.

Akkuzid, application instruction (Way and dosage)

Pill of Akkuzit is taken 1 time a day without binding to meal. The recommended initial daily dose to patients who do not receive diuretic makes 10 mg +12.5 mg (one tablet of Akkuzit 10); in case of need the initial daily dose increases to the maximum daily dose — 20 mg +25 mg (one tablet of Akkuzit 20). As a rule, the effect comes at administration of drug in the range of dosages from (10 +12.5 to 20 +12.5) mg a day. It is not required to patients of advanced age of dose adjustment. In the presence of the expressed disturbances of kidneys at patients drug as initial therapy should not be applied.

Overdose

The main manifestations of overdose at long administration of drug in the doses exceeding therapeutic are permanent decrease in the ABP, disturbance of the water and electrolytic balance which is shown a hypochloraemia, a hyponatremia, a hypopotassemia.

Interaction

At a concomitant use of Akkuzid with antibiotics of group of tetracyclines, process of absorption of tetracycline decreases on a third. It is not recommended to appoint lithium drugs together with diuretics as diuretics lower renal clearance of lithium and sharply the risk of intoxication increases. At a concomitant use with Akkuzid of ethanol, opioid analgetics, barbiturates and HP with for the general anesthesia the risk of development of orthostatic hypotension increases. At single-step reception of Akkuzid with insulin or hypoglycemic HP correction of a dosage of hypoglycemic means is necessary. The hydrochlorothiazide as a part of Akkuzid strengthens action of the anti-hypertensive means accepted along with it.

At a concomitant use with Akkuzid of corticosteroid drugs, strengthening of loss of potassium and other electrolytes is possible. Reception of NPVS causes weakening of an anti-hypertensive, diuretic and natriuretic effect of diuretics. At a concomitant use with Akkuzid of muscle relaxants strengthening of their action is possible.

Terms of sale

Prescription sale.

Storage conditions

At a temperature up to 25 °C.

Period of validity

3 years.

Akkuzid's analogs

There are no analogs of drug on active ingredient. Drugs with similar action are Kvinapril, Kvinard.

About Akkuzida

About drug among patients favorable:
"… I have a diagnosis arterial hypertensia was revealed in 30 years. Had several hypertensive crises. Constantly called emergency doctors. As a result at nemya pressure often increased, it was necessary to call the ambulance. Recently appointed and the situation with pressure was normalized. I take one pill a day on an empty stomach in the morning and pressure is normal the whole day. In three years any pobochek from it was not".

Zdravzona

  • Akkuzid of 20 mg +25mg No. 30 tabletkigoedecke GmbH
  • Akkuzid of 20 mg +12,5mg No. 30 tabletkigoedecke GmbH

Drugstore of IFC

  • Akkuzid tbl p / about 20 mg +25mg No. 30, Goedecke Gmbhgermaniya
  • Akkuzid tbl p / about 20 mg +12.5mg No. 30, Goedecke Gmbhgermaniya
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Apteka24

  • Akkuzid of a tablet coated 10 mg No. 30gedeke of AG (Germany)
  • Akkuzid of a tablet coated 20 mg No. 30gedeke of AG (Germany)

Paniapteka

  • Akkuzid of the tab. p / about 10 mg No. 30pfayzer
  • Akkuzid of the tab. p / about 10 mg No. 30pfayzer

BIOSPHERE

  • Akkuzid of 20 mg / 12,5 mg No. 30 tabl.p.o.godecke GmbH (Germany)
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Section: Cardiovascular
in more detail

Education: Graduated from Sverdlovsk medical school (1968 - 1971) as "Paramedic". Graduated from the Donetsk medical institute (1975 - 1981) as "An epidemiologist, a hygienist". Passed postgraduate study in the Central scientific research institute of epidemiology Moscow (1986 - 1989). An academic degree – the candidate of medical sciences (degree is awarded in 1989, protection – the Central scientific research institute of epidemiology Moscow). Numerous advanced training courses are studied in epidemiology and infectious diseases.

Experience: Work as the manager of department of disinfection and sterilization of 1981 - 1992. Work as the manager of department of especially dangerous infections of 1992 - 2010. Teaching activity at Medical institute 2010 - 2013.

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