Akridilol

Акридилол Drug photo

The description is actual on 27.07.2016

  • Latin name: Acridilole
  • ATH code: C07AG02
  • Active ingredient: Karvedilol (Carvedilol)
  • Producer: Chemical and pharmaceutical QUINACRINE combine, joint stock company (Russia)

Structure

Karvedilol, monohydrate of lactose, sodium carboxymethylstarch, povidone, magnesium stearate.

Release form

Is issued in tablets 12,5 and 25 of mg of a biconvex oval form of white color in the blister in cardboard packaging No. 30.

Pharmacological action

The main action — hypotensive, anti-anginal.

Pharmacodynamics and pharmacokinetics

Pharmacodynamics

The drug which is blocking an alpha and beta adrenoceptors, not possessing sympathomimetic activity. Selectively blocking myocardium β-adrenoceptors drug reduces cordial emission and ChSS, the ABP reduces, and blocking of α-adrenoceptors expands a gleam of peripheral vessels. As a result, oxygen requirement decreases, OPSS decreases and myocardium ischemia is prevented. At patients with heart failure emission of a left ventricle increases. Clinically expressed effect (influence on ChSS and the ABP) comes in 1 hour after reception of tablets.

Pharmacokinetics

Drug is well soaked up from a gastrointestinal tract. Cmax in blood comes in 1,5 hours. Bioavailability of drug about 25%. High communication with blood proteins at the level of 95%. Gets through GEB, it is allocated with breast milk. It Biotransformirutsya in a liver by two cycles with formation of active metabolites. It is brought out of an organism with a stake and urine. T1/2 — about 10 hours.

Indications to Akridilol's use

In mono - or a combination therapy of arterial hypertension, HSN and ischemic heart disease.

Contraindications

High sensitivity to drug, AV blockade of the II-III degree, arterial hypotension, the expressed bradycardia, cardiogenic shock, the expressed liver failure, age till 18 flyings, a chronic obstructive pulmonary disease.

To take with caution at a thyrotoxicosis, psoriasis, the blockade of the I degree, a diabetes mellitus expressed to a renal failure, AV, a myasthenia, a pheochromocytoma, a depression, a hypoglycemia, after the general anesthesia.

Side effects

Increased fatigue, headaches, dizziness, sleep disorder, loss of consciousness, paresthesias, a depression, bradycardia, decrease in the ABP, hypostases of the lower extremities, appetite loss, diarrhea or a lock, nausea, dryness in a mouth, an abdominal pain, vomiting, a leukopenia, increase in body weight, local allergic reactions, an asthma, a mialgiya, a grippopodobny syndrome.

Akridilol, application instruction (Way and dosage)

To accept according to the scheme, according to a look and disease severity.

At arterial hypertension the drug dose during the first two days varies within 6,25–12,5 mg, is accepted once a day. Then the dose increases to 25 mg, to accept once a day. At poorly expressed anti-hypertensive action in 2 weeks of treatment the dose of drug can be increased to the maximum daily dosage — 50 mg.

Ischemic heart diseases — in the first two days of treatment appoint 12,5 mg 2 times a day. Then the dosage is increased to 25 mg by 2 times a day, and in the absence of effect the daily dose is increased to 100 mg divided into 2 receptions.

HSN — a dose is selected in each case. The initial dose is recommended to 3,125 mg twice a day for 14 days. At good health in 2 weeks the dosage is increased to 6,25 mg, then — to 12,5 mg and to 25 mg twice a day. If necessary it is possible to appoint drug in the maximum daily dose of 50 mg.

Overdose

It is shown by decrease in the ABP, a faint, bradycardia, vomiting and short wind. In hard cases — breath disturbance, shock, confusion of consciousness.

Interaction

To accept carefully with other anti-hypertensive means as karvedilol strengthens their action. At a concomitant use of drug with diltiazem the risk of disturbance of a hemodynamics and conductivity of heart increases.

Karvedilol strengthens effect of insulin and other sakharosnizhayushchy means. Cimetidinum strengthens, and rifampicin and phenobarbital weaken hypotensive effect of a karvedilol.

MAO inhibitors and Reserpinum strengthen risk of development of the expressed bradycardia and arterial hypotension.

The concomitant use of a clonidine can strengthen considerably anti-hypertensive effect of a karvedilol and urezhat a cordial rhythm. The general anesthetics strengthen hypotensive effect of drug and a negative inotropic effect.

Terms of sale

Prescription issue.

Storage conditions

At a temperature up to 25 °C.

Period of validity

36 months.

Akridilol's analogs

Coincidence on the ATH code of the 4th level:

Attram, Karvedilol, Bagodilol, Dilatrend, Karvedigamma, Vedikardol, Karvenal, Karvetrend, Koriol, Karvidil, Kredeks, Kardivas, Talliton and others.

About Akridilole

About drug at most of patients positive.

"… Lately because of the conflict at work pressure began to increase, to be turned the head, to become frequent pulse, the general weakness appeared. The doctor appointed tablets Akridilol. After a reception course the health improved, passed inspection, everything is all right".

Zdravzona

  • Akridilol of 25 mg No. 30 tabletkiakrikhin HFK of joint stock company
  • Akridilol 12,5mg No. 30 tabletkiakrikhin HFK of joint stock company
  • Akridilol 6,25mg No. 30 tabletkiakrikhin HFK of joint stock company

Drugstore of IFC

  • Akridilol tbl 12.5mg No. 30 **, HFK (г.Москва) Russia Quinacrine
  • Akridilol tbl 12.5mg No. 30, HFK (г.Москва) Russia Quinacrine
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Section: Cardiovascular
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Education: Graduated from Sverdlovsk medical school (1968 - 1971) as "Paramedic". Graduated from the Donetsk medical institute (1975 - 1981) as "An epidemiologist, a hygienist". Passed postgraduate study in the Central scientific research institute of epidemiology Moscow (1986 - 1989). An academic degree – the candidate of medical sciences (degree is awarded in 1989, protection – the Central scientific research institute of epidemiology Moscow). Numerous advanced training courses are studied in epidemiology and infectious diseases.

Experience: Work as the manager of department of disinfection and sterilization of 1981 - 1992. Work as the manager of department of especially dangerous infections of 1992 - 2010. Teaching activity at Medical institute 2010 - 2013.

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