Albumine

Альбумин Drug photo

The description is actual on 05.07.2016

  • Latin name: Albumin
  • ATH code: B05AA01
  • Active ingredient: Albumine of the person (Albumin human)
  • Producer: A microgene of NPO Federal State Unitary Enterprise (Immunopreparat), Sangvis of joint project company No. 2 ABOUT public healthcare institution, Mikrogen of NPO Federal State Unitary Enterprise (NPO Virion) (Russia), etc.

Structure

In 1 ml of solution albumine of human 50 mg, 100 or 200 mg.

Tryptophane, sodium, potassium, caprylic acid, water — as excipients.

Release form

Solution for infusions of 10% on 200 ml and 100 ml.

Solution for infusions of 5% and 20% on 50 ml or 100 ml.

Pharmacological action

Plasma substituting.

Pharmacodynamics and pharmacokinetics

Pharmacodynamics

Albumine is a plasma substituting drug which is received at fractionation of blood, plasma and serum of donors. Its introduction compensates for the plasma albumine deficiency (is a protein source), supports oncotic pressure, increases the plasma volume (at some patients this effect remains several hours) and the ABP, possesses disintoxication properties. Let out in the form of 5%, 10% and 20% of solutions. After flood bottles will pasteurize at 600 C, 10 h in order to avoid transfer of serumal hepatitis. 5% solution — isooncotic plasmas, and 20% — hyper oncotic.

Pharmacokinetics

T1/2 makes 19 days. Removal in the intracellular way with participation of lizosomalny proteases. At healthy faces of 10% of the entered solution it is brought out of a bed in the first 2 h. Heavy patients lose significant amounts of protein therefore it is difficult to predict the speed of an exit.

Indications to use

  • burns;
  • shock;
  • hypoalbuminemia against a nutritional dystrophy, a glomerulonephritis, cirrhosis, purulent processes, nonspecific ulcer colitis and tumors of a gastrointestinal tract;
  • medical plasma exchange;
  • completion of OTsK;
  • brain hypostasis;
  • at operations in the conditions of artificial circulation;
  • preoperative hemodilution.

Contraindications

  • hypersensitivity;
  • the expressed heart failure;
  • hypervolemia;
  • fluid lungs;
  • arterial hypertension;
  • heavy anemia;
  • thrombosis;
  • the proceeding bleeding.

With care it is appointed at pregnancy (only then if the potential advantage for the pregnant woman exceeds risk for a fruit) renal and heart failure, at hemorrhagic diathesis.

Side effects

Albumine, application instruction (Way and dosage)

Solution is entered in/in kapelno. The single dose is defined with weight of a condition of the patient and depends on the volume of the circulating blood, but not level of protein in plasma. For 5% of solution a single dose — 300-500 ml which is entered with a speed up to 60 thaws a minute. 10% the drug are administered with a speed of 40-50 thaws a minute and a dose of its 300 ml. To elderly people drive even more slowly solution to avoid a heart overload. To children Albumine in/in is appointed at the rate of 3 ml to weight kg.

Rate of administering of 20% of drug to 40 drops a minute, is disposable entered by 50 - 100 - 200 ml. At exchange substitution of plasma speed is higher. As 20% solution are effectively increased by osmotic pressure, in the course of its introduction there has to be a vigilance in respect of an overload of blood circulation and emergence of overhydratation. This solution can be dissolved with normal saline solution.

The application instruction of Albumine contains the warning that infusion can be carried out if solution in a bottle transparent, and glass packaging is tight. At dehydration administration of drug needs to be made after completion of an organism the liquid accepted inside or parenterally. Before introduction drug needs to be held at the room temperature and it is entered right after opening of a bottle.

Overdose

Overdose appears at an excessive speed of infusion or at discrepancy of a dose to parameters of blood circulation. It is shown by a hypervolemia: increase of the ABP, the accruing heart failure and renal. Administration of drug stops, carried out a regidratation and symptomatic therapy.

Interaction

Let's combine with a whole blood, electrolytic solutions, a packed red cells. It is impossible to mix with proteinaceous hydrolyzates, alcohol-containing solutions and solutions of amino acids. At simultaneous use with APF inhibitors there is a risk of arterial hypotension.

Terms of sale

It is released according to the recipe of the doctor.

Storage conditions

Temperature of storage is up to 10 °C.

Period of validity

3 years.

Analogs

Coincidence on the ATH code of the 4th level:

Plazbumin 20, Albumine of 20%, Albureks, Zenalb-20, Postab solution.

Responses

The amino acids which came to an organism with food undergo in a transformation liver: part are used for synthesis of purine nucleotides, uric acid, creatine, the part is exposed to disintegration, and from some quantity fabric proteins, hormones and enzymes are synthesized. Hepatocytes synthesize all albumine and globulins: 75–90% of α-globulins and 50% β - globulins.

Albumine in blood — the regulator of osmotic pressure of blood, and also is the transport protein transferring free fatty acids, hormones (thyroxine and triiodothyronine), not conjugated bilirubin, enzymes, medicines. Norm of albumine in blood of 40-50 g/l., and at urine there should not be squirrels. Emergence it testifies to pathology of the glomerular device of kidneys at arterial hypertension, a diabetes mellitus, a system lupus, congestive heart failure, tumors of adrenal glands, a nephropathy of pregnant women and diseases of kidneys.

If in blood albumine is raised what reasons of it? Increase in its level testifies to a pachemia. Such state is observed if the person intensively loses liquid (vomiting, a diarrhea, plentiful sweating), and arrives it very little. However, its high concentration has no essential value.

Albumine can be lowered at pathological processes in a liver — at cirrhosis there is a sharp decrease in its synthesis. As its level in plasma falls, oncotic pressure decreases and albumine comes to intercellular space — hypostases and ascites develop. Decrease in level of this protein is noted at increase of permeability of capillaries, losses of protein at heavy sepsis, burns, malignant new growths, at starvation, a thyrotoxicosis and a nephrotic syndrome.

With the medical purpose medical supply — Albumine is used, what is it? This drug is received from donor blood of the person, but not animals, and applied at a hypodisproteinemia, deficit of OTsK — as it possesses oncotic properties (holds water in a blood channel and increases OTsK). It is appointed at shock, burns, a hypoalbuminemia at tumoral diseases, heavy pyoinflammatory processes, at blood loss (in combination with hemotransfusion and a packed red cells). In a type of high price of drug recently it is applied only at the expressed hypoalbuminemia. In other cases alternative drugs are modern synthetic colloid plasma substitutes. Enter Albumine in/in and as it represents a foreign protein, before introduction carry out a bioassey.

About this drug contradictory:

  • "… From albumine pressure rises even above";
  • "… To me it was done by 7 droppers. Transferred normally";
  • "… At ascites to mother dripped it dripped. He does the part, but not quickly";
  • "… Administration of albumine for 4-5 days increases its level, and then it falls again";
  • "… To the child with his low albumine dripped. There were severe hypostases, protein in urine. Hypostases left, weight was lost by kilograms".

What else drugs of albumine exist and what aspects of their use in medicine? Serumal bull albumine is a dry lyophilisate which is applied to the diagnostic purposes. Process of production its not the road therefore it is the most widespread reactant at biochemical researches.

Often on the Internet the question meets: "What is albumine food black and whether it has relation to medicine? Whether it is worth accepting it most and to give to children?" Albumine food black is made of powder of blood of a cattle and is a part of hematogen — ferriferous drug. Such erythrocyte concentrate is an iron source. For improvement of taste condensed milk, ascorbic acid, sugar syrup, treacle is added.

Actually, that it is it Albumine food black — panacea or a self-consolation, a delicacy or drug? It is useful or conceals in itself danger? Considering the fact that hematogen is made at the pharmaceutical enterprises, it is possible to be sure that blood passes special processing, and it excludes transfer of various infectious diseases to the person. It is released as medicine through pharmacy chain therefore it not a delicacy, and medicine. To give to children and to accept most it is necessary in the dosage specified in the instruction or the doctor.

Overdose can cause vomiting and a diarrhea, allergic reactions. The maximum quantity — 50 g a day for adults and 25 g for children. At all this we cannot have 100% confidence that blood does not contain hormones, stimulators, medicines which gave to an animal. So it is impossible to establish true character of Albumine and that more it bears — advantage or harm.

  • "… I did not love hematogen, and its taste was not pleasant to me. To sweet it is indifferent";
  • "… During pregnancy so wanted it and ate 3 pieces a day";
  • "... I consider useful and I give to the child, but moderately!".

Ovalbumin which is often bought in online stores represents powder with a smell of eggs and receive it from proteins of eggs. It is the digestible concentrated protein which is accepted by bodybuilders as protein cocktails or add to dishes. It is a part of dietary supplement for the people who are intensively playing sports for accumulation of muscle bulk.

This protein is used in the food industry: production of wines and cognacs, preparation of confectionery, cakes, a souffle, meringue, a zephyr, and also in house cookery. At qualitative raw materials there are no salmonellas and colibacilli. Powder is stored in a tight container and dry conditions about one year. It is implemented only in bags on 20 kg. The persons having an allergy to protein cannot use it. Emergence of locks, a meteorism, neurologic frustration is possible.

Zdravzona

  • Albumine solution for infusions of 10% 100 ml No. 1 flakonmikrogen NPO Federal State Unitary Enterprise
  • Albumine solution for infusions of 20% 100 ml No. 1 flakonmikrogen NPO Federal State Unitary Enterprise
  • Albumine solution for infusions of 20% 100 ml No. 1 bottle/Baxter/Baxter
  • Albumine solution for infusions of 20% 50 ml No. 1 bottle/Baxter/Baxter
  • Uman albumine solution for infusions 200mg/ml 50mlkelrion

Drugstore of IFC

  • Albumine fl 20% 100 ml fl with the holder., Oktafarm Pharmaceutics Produktionoges mbavstriya
  • Albumine fl 10% 100 ml, Mikrogen of NGO (Immunopreparauf) Russia
  • Albumine fl 10% 100 ml, Mikrogen of NPO Federal State Unitary Enterprise (Biohoney of NGO (Perm) Russia
  • Albumine fl 20% 100 ml, Mikrogen of NPO Federal State Unitary Enterprise (Virion of NGO Tomsk) Russia
  • Albumine fl 20% 50 ml fl with the holder., Oktafarm Pharmaceutics Produktionoges mbavstriya
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Apteka24

  • Albumine solution of 10% 20mlbiofarma (Ukraine, Kiev)
  • Albumine solution of 20% 100mlbiofarma (Ukraine, Kiev)
  • Albumine solution of 10% 50mlbiofarma (Ukraine, Kiev)
  • Albumine solution of 20% 50mlbiofarma (Ukraine, Kiev)
  • Albuminbiofarm (Ukraine, Kiev)

BIOSPHERE

  • Albumine of 10% 100 ml solution for inf.fl. Regional center of KGKP blood, Karaganda (Kazakhstan)
  • Albumine of 10% 200 ml solution for inf.fl. Republican center of blood (Kazakhstan)
  • Albumine of 10% 100 ml solution for inf.fl. Republican center of blood (Kazakhstan)
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Section: For blood
in more detail

Education: Graduated from Sverdlovsk medical school (1968 - 1971) as "Paramedic". Graduated from the Donetsk medical institute (1975 - 1981) as "An epidemiologist, a hygienist". Passed postgraduate study in the Central scientific research institute of epidemiology Moscow (1986 - 1989). An academic degree – the candidate of medical sciences (degree is awarded in 1989, protection – the Central scientific research institute of epidemiology Moscow). Numerous advanced training courses are studied in epidemiology and infectious diseases.

Experience: Work as the manager of department of disinfection and sterilization of 1981 - 1992. Work as the manager of department of especially dangerous infections of 1992 - 2010. Teaching activity at Medical institute 2010 - 2013.

PAY ATTENTION! Information on drugs on the website is help generalizing, collected from public sources and can form the basis for making decision on use of medicines it is not aware of treatment. Before medicine use Albumine surely consult with the attending physician.