Alerana

Алерана Drug photo

The description is actual on 04.03.2015

  • Latin name: Alerana
  • ATH code: D11AX01
  • Active ingredient: Minoksidil (Minoxidil)
  • Producer: VERTEXUM (Russia)

Structure

Composition of shampoo:

  • minoksidit;
  • horse-chestnut extract;
  • wormwood;
  • sage;
  • poppy extract;
  • B5 vitamin (pantothenic acid).

"Put" composition of vitamins of a formula:

The vitamin and mineral Night complex consists from:

Auxiliary components of vitamin complexes include:

  • microcrystallic cellulose – 319,3 mg;
  • potato starch – 28 mg;
  • silicon dioskid (aerosil) – 6 mg;
  • calcium stearate – 5,9 mg;
  • cover – 33 mg for a day tablet and 25 mg for night.

Composition of spray for external use of 2% (5%):

  • minoksidit – 20 mg in 1 ml (50 mg in 1 ml);
  • ethanol;
  • propylene glycol;
  • the water purified.

Structure of a brasmatika-growth-promoting factor of eyelashes of Aleran:

  • vitamin E (alpha tocopherol);
  • panthenol;
  • sodium hyalrunate;
  • nettle extract;
  • jojoba oil;
  • chestnut extract;
  • almonds oil;
  • ceramides;
  • oil burdock;
  • taurine;
  • castor oil.

Release form

  • Aleran's spray for external use, regardless of concentration of active component, is packed up in polyethylene bottles on 50 or 60 ml corked by dosers. The aerosol in cardboard packs together with the summary to pharmaceutical drug and the special extended raspylitelny nozzle is located.
  • Shampoo against baldness for all types of hair in a bottle with a capacity of 200 ml.
  • Growth-promoting factor for eyelashes and Aleran's eyebrows in the form of a brasmatik in a case of 2х6 ml.
  • Vitamin and mineral complex in the form of tablets coated in blisters on 20 pieces. In total in a cardboard pack 3 cell planimetric plates.

Pharmacological action

Medicine is used for care of pilar part of the head for the purpose of braking of process of an alopecia. At topical administration the main active components exert stimulating impact on growth of hair by improvement of blood circulation in a microcirculator bed that is shown in transition of hair follicles to the active or growing phase. Minoksidil changes influence of male sex hormones on hair sacks, according to the action mechanism, it reduces education 5 - alpha degidrosterona which indirectly plays a role in forming of baldness.

The optimum effect of pharmaceutical drug is noted at:

  • prescription of a disease (androgenic alopecia) no more than 10 years;
  • young age of the patient;
  • diameter of a bald head or bald spot in the field of a darkness no more than 10 cm;
  • existence in the center of the pathological center more than 100 vellus and terminal hair.

Emergence of signs of growth of hair noticeable with the naked eye is noted in 4 and more months of a conservative course of treatment of nosological unit. After phase-out of pharmaceutical drug vigorous activity of follicles gradually comes to naught, and within 3-4 months recovery of initial outward of pilar part of the head is possible.

Auxiliary components of shampoo also have important pharmacological effect on head skin and on hair follicles. Extracts from a horse-chestnut, a sage and a wormwood calm and remove irritation, poppy extract adds healthy gloss to hair, and B5 vitamin well humidifies integuments.

Pharmacodynamics and pharmacokinetics

Minoksidil makes local impact on head integuments therefore possesses low absorbtivny abilities, that is only 1,5% of the general put dose come to a system blood stream. After the termination of a course of conservative treatment of 95% of an active component it is brought out of an organism within 4 days. Metabolic ways of biotransformation of the operating component after outside use until now are studied not completely.

It is known that minoksidit it is removed mainly by kidneys by means of glomerular filtering or by means of a hemodialysis.

Indications to use

  • androgenic alopecia;
  • recovery of indumentum;
  • stabilization of process of a hair loss;
  • care of the weakened thinned eyelashes and eyebrows.

Contraindications

  • hypersensitivity to compound components of cosmetic;
  • the hereditary or acquired intolerance to active and to excipients of pharmaceutical drug;
  • the age is younger than 18 years;
  • disturbance of integrity of integuments;
  • dermatosis of pilar part of the head;
  • advanced age is more senior than 65 years.

Side effects

Local side effects:

  • dermatitis of pilar part of the head;
  • hyperemia of integuments;
  • peeling;
  • inflammatory processes in the field of hair follicles;
  • head itch;
  • allergic contact dermatitis;
  • hypertrichosis – the excess growth of hair on uncharacteristic sites of skin or unusual this floor or I will increase;
  • seborrhea;
  • strengthening of a hair loss (upon transition from a resting phase to active growth when "old" indumentum is replaced new 2-6 weeks later from the beginning of a conservative course of treatment).

System adverse effects of therapeutic intervention:

  • nonspecific allergic reactions – skin rash, the small tortoiseshell, a face edema;
  • asthma;
  • vasculomotor allergic rhinitis;
  • headache and dizziness;
  • vertigo;
  • nonspecific neuritis;
  • thorax pain;
  • cardiopalmus;
  • uncontrollable rises and lowerings of arterial pressure;
  • change of a rhythm of cordial activity.

Application instruction (Way and dosage)

The instruction on Aleran's spray

It is used for outside drawing on dry skin of pilar part of the head. Medicine does not demand washing off. The processed site evenly becomes covered by 1 ml of pharmaceutical drug 2 times a day that corresponds to 7 pressing for 1 manipulation. It is put beginning from the center of the pathological center to the periphery. After Alerana's use in the form of spray it is necessary to wash carefully hands with soap.

The total daily dose should not exceed 2 ml, even at the big sizes of a site of an alopecia. If after use of 2% of therapeutic solution of positive cosmetic effect within 3-4 months it is not observed, then it is necessary to pass to stronger pharmaceutical drug with a dosage of active component into 5%. The general duration of a course of conservative treatment makes, on average, 1 year.

The doser fixed on a bottle is suitable for putting spray directly on problem sites of pilar part of the head better. If the pathological center of baldness is under long hair or extends to the small square, then it is recommended to use the extended raspylitelny nozzle which goes complete with medicine.

How to use shampoo against a hair loss?

Means in a small amount is applied on the wet, previously washed up with usual shampoo hair. By means of the massing movements therapeutic means is distributed evenly by all pilar part of the head and promote more dense interaction with the hair follicles located at a root of each separate hair. Further shake up foam, as when using usual daily shampoo that auxiliary components rendered the pharmacological effects on length of a healthy hair. Exposure makes from 1 to 3 minutes then shampoo is washed away warm flowing water.

How to accept a vitamin and mineral complex?

Aleran's vitamins contain two formulas with characteristic names "Day" and "Night" which are applied respectively. It is recommended to use tablets during food when the digestive tract is most prepared for absorption of useful components of components. Duration of a conservative course of treatment makes 1-3 months, and it is possible to repeat such therapy 2-3 times a year, depending on individual indicators of a vitamin and mineral exchange. For achievement of optimum effect the combined use of several pharmaceutical forms of drug is recommended.

Route of administration of a growth-promoting factor of eyelashes and eyebrows

As well as the vitamin and mineral complex, cosmetic brasmatik is delivered in the form of two formulas – day and night which are used daily. The variation of pharmaceutical means with the name "Day" is recommended to be applied on eyelashes and eyebrows after morning washing, it well approaches as a basis under mascaras. It can also be used when carrying contact lenses, it will not affect therapeutic effects of medicine.

The formula "Night" is put after evening hygienic procedures when the day make-up is already removed by special gels for washing. The open case should be held a white cover up not to spend pharmaceutical drug for nothing.

For achievement of resistant result it is recommended to conduct courses of conservative treatment for 1-3 months, depending on an initial condition of eyelashes and eyebrows. It is possible to repeat therapeutic procedures not more often than twice a year. When using cosmetics it is necessary to avoid hit on mucous, otherwise it is worth washing out plentifully eyes flowing water and to see the attending physician for the help if there were any side effects.

Overdose

Accidental intake of medicine can cause the systemic side effects caused by vasodilating effects of a minoksidil as the peroral form of an active component is used in pharmacy as anti-hypertensive drug. Overdose symptoms:

  • liquid delay;
  • lowering of arterial pressure;
  • tachycardia.

There is no specific pharmacological antidote for a minoksidil therefore symptomatic medicamentous therapy is used. For elimination of a delay of water diuretics, for correction of a rhythm of cordial activity – beta adrenoblockers are appointed. Level of arterial pressure is recommended to be sanified administration of not cardiostimulating medicines, and increase of volume of the circulating blood, for example, by means of isotonic solution of sodium of chloride.

Interaction

During clinical trials it was proved that minoksidit for hair can interact with some medicines which are used locally. So, for example, external use cream with Betamethasone or Tretinoin (the minimum concentration of active components – 0,05%) causes change of protective functions of integuments that can lead to increase in absorption of a minoksidil and the corresponding system side effects.

From the point of view of theoretical medicine there is a possibility of strengthening of orthostatic hypotension at co-administration of pharmaceutical drugs on the basis of a minoksidil outwardly with peripheral vasodilators for peroral use. Also it is impossible to exclude slight increase of concentration of a minoksidil in a circulatory bed at therapy of arterial hypertension that can be result of the combined purpose of local and system forms of medicine, however clinical trials on the matter were not conducted.

Terms of sale

Pharmaceutical drug is allowed for nonprescription acquisition in pharmaceutical booths and the licensed points of sale of cosmetics.

Storage conditions

To store in dry, protected from direct sunshine and the place, unavailable to children of younger age, at a temperature not above 25 degrees Celsius.

Period of validity

2 years.

Special instructions

To avoid hit of pharmaceutical drug in eyes and on other mucous membranes. After medicine use carefully to wash up hands.

To children

Pharmaceutical drug is contraindicated for use till 18 flyings.

Zdravzona

  • Alerana the fat and combined hair shampoo 250mlalerana
  • Alerana vitamin and mineral complex No. 60 of a tabletkialeran
  • Alerana a mask for hair of 15 ml 6shtalerana
  • Alerana conditioner for all types of hair 200mlalerana
  • Alerana tonic leaving for all types of hair 100mlalerana

Drugstore of IFC

  • Alerana spray of 2% 60 ml, Zaorossiya's Vertexum
  • Alerana vitamin and mineral complex tbl No. 60, Zaorossiya's Vertexum
  • Alerana shampoo from dandruff of 250 ml, Zaorossiya's Vertexum
  • Alerana toner leaving for hair of 100 ml, Zaorossiya's Vertexum
  • Alerana conditioner for all types of hair of 200 ml, Zaorossiya's Vertexum
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Section: Dermatological
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Education: Kharkiv national medical university

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