Амикс Drug photo

The description is actual on 12.02.2015

  • Latin name: Amyx
  • ATH code: A10BB12
  • Active ingredient: Glimepirid (Glimepiride)
  • Producer: Zentiva (Czech Republic)


  • One tablet of drug of Amiks 1 contains 1 mg of a glimepirid.
  • One tablet of drug of Amiks 2 contains 2 mg of a glimepirid.
  • One tablet of drug of Amiks 3 contains 3 mg of a glimepirid.
  • One tablet of drug of Amiks 4 contains 4 mg of a glimepirid.

Additional components: povidone 25, lactose, polysorbate 80, microcrystallic cellulose, krospovidon, silicon dioxide, magnesium stearate, iron oxide, dye.

Release form

  • Amiks 1: pink tablets of an oval form with dividing line from two parties.
  • Amiks 2: greenish tablets of an oval form with dividing line from two parties.
  • Amiks 3: yellowish tablets of an oval form with dividing line from two parties.
  • Amiks 4: blue tablets of an oval form with dividing line from two parties.

10 tablets in the blister — three, nine or twelve blisters in cardboard packaging.

Pharmacological action

Hypoglycemic effect.

Pharmacodynamics and pharmacokinetics


Glimepirid is a gipoglikemiziruyushchy means for oral administration (derivative sulfonilmochevina). Activates release of insulin pancreatic B-cells, strengthens insulin release, increases sensitivity of fabrics to insulin molecules.


After reception bioavailability of a glimepirid approaches 100%. The food does not influence extent of absorption, and brakes it some. The maximum concentration in blood (are fixed in 2-3 hours after the use inside.)

Extent of linkng with plasma proteins – more than 99%. Time of semi-removal makes 6-8 hours. It is metabolized completely. It is removed with urine and through intestines.

Indications to use

Diabetes mellitus of the second type at which the content of glucose in blood cannot be supported adequately by a diet, weight reduction or physical exercises.


Diabetes mellitus of the first type, diabetic coma, diabetic ketoacidosis, pregnancy or lactation. Also drug cannot be recommended to patients with a sensitization for drug components, derivatives of a sulfonilmochevina or for other sulfanamide drugs.

Side effects

Development of the following signs of a hypoglycemia is possible: "wolf" appetite, nausea, apathy, vomiting, drowsiness, headache, uneasiness, aggression, sleep disorder, concentration disturbance, decrease in reaction, confusion of consciousness, depression, disturbance of the speech, vision disorder, aphasia, tremor, sensitivity disturbance, paresis, dizziness, delirium, central spasms, loss of consciousness, bradycardia. Adrenergic reactions are also possible: feeling of alarm, perspiration, arterial hypertension, stenocardia attacks, tachycardia, arrhythmia.

From sight: temporary vision disorders.

From digestion: an abdominal pain, nausea, vomiting, feeling of overflow in epigastriums, diarrhea, change of content of enzymes of a liver, hepatitis.

From a hemopoiesis: leukopenia, agranulocytosis, thrombocytopenia, hemolitic anemia, granulocytopenia, erythrocytopenia, pancytopenia.

Other side reactions: itch, urticaria, dispnoe, reduction of pressure.

In extremely exceptional cases can be also observed: a photosensitization, an allergic vasculitis, reduction of level of sodium in blood.

Application instruction (Way and dosage)

Main conditions of successful therapy: dietary food, constant exercise stresses and constant control of indicators of blood and urine. The dosage of drug is determined by results of analyses.

The initial dose of means makes 1 mg of a glimepirid daily. The same dose is used as the supporting treatment at achievement of control of a condition of the patient.

If the desirable control of a condition of the patient does not manage to be reached, the dosage is raised on 1, 3 or 2 mg of a glimepirid a day by each one-two weeks.

Reception of a glimepirid over 4 mg a day gives improvement only in special cases. The maximum dose – to 6 mg of drug a day.

At patients without compensation of disturbances of an exchange of carbohydrates even after the use of the maximum doses, it is possible to begin treatment with insulin only at emergency. Such patients should continue to use the previous dose of drug and at the same time to begin to use small doses of insulin, further it is authorized to increase them gradually according to the level of metabolic compensation.

Distribution of a day dose

Usually for an organism it is enough to accept one day dose to or during a breakfast. If the patient forgets to accept the next dose, then the subsequent dose does not need to be increased.

Subsequent dose adjustment

During treatment growth of sensitivity to insulin and decrease in need for a glimepirida is possible. Therefore for the prevention of a hypoglycemia it is necessary to lower adequately dosages or to cancel drug. At increase or weight reduction, changes of way of life or emergence of other factors which increase risk of emergence of a hypoglycemia or hyperglycemia it is necessary to reconsider values of dosages of drug.

Transition from other peroral hypoglycemic means to Amiks's use

In this situation it is necessary to consider extent of impact of drugs on an organism and time from semi-removal. At the previous use of the prolonged antidiabetic means with big half-life it is recommended to begin therapy the Amiksy ambassador of the expiration of the period of removal as the perhaps additive action.

Transition from reception of insulin to Amiks

In special cases when the condition of patients with a diabetes mellitus of the second type is regulated insulin, there can be indications for transition on glimepirid. Transition to Amiks at these patients needs to be carried out under supervision of the attending physician.


After overdose by drug emergence of a hypoglycemia which can last from 12 hours to 3 days is probable. Hospitalization in department of the general type is recommended. Vomiting or nausea, an abdominal pain, excitement, a vision disorder, a tremor, disorders of coordination, drowsiness, sleeplessness, a coma and spasms can be symptoms of overdose.

Therapy of overdose consists of performance of a gastric lavage, reception of drinking water, absorbent carbon and sodium of sulfate. Also as soon as possible it is necessary to begin glucose use. Further therapy has to have symptomatic character.


At combined use with Phenylbutazone, Azapropazon, Metforminum, Oksifenbutazon, insulin, peroral anti-diabetic means, salicylates, anabolic steroids, androgens, anticoagulants of coumarinic type, chloramphenicol, Fenfluramin, fibrata, APF inhibitors, Fluoxetine, sympatholytics, Allopyrinolum, Sulfinpyrazonum development of a hypoglycemia is possible.

At simultaneous use of the estrogen, saluretics, progestrogen, thiazide diuretics, glucocorticoids, tireostimuliruyushchy drugs derivative of a fenotiazin (Adrenaline, Chlorpromazinum), sympathomimetics, niacin and its derivatives, laxatives, Phenytoinum, the Glucagon, Diazoxide, Rifampicin, barbiturates, Atsetozolamid weakening of effect of drug and increase of concentration of glucose in blood is possible.

Glimepirid changes effects of kumarinopodobny drugs.

Terms of sale

Drug can be bought only according to the recipe.

Storage conditions

To protect from children. To store at a temperature up to 30 degrees.

Period of validity

2 years.

Special instructions

In the initiation of treatment at the patient increase in risk of emergence of a hypoglycemia is possible – it demands careful supervision over its state. Treat the factors lowering concentration of glucose in plasma: irregular food, errors in a diet, malnutrition, non-compliance with a diet, the admission of receptions of food.


Amipirid, Amaryl, Glayri, Glemaz, Glianov, Glimaks, Glinova, Glirid, Dimaril, Diapirid, Oltar, Perinel, Elgim.


  • Amiksin of 125 mg No. 6 tabletkifarmstandart-Tomskhimfarm joint stock company
  • Amiksin of 125 mg No. 10 tabletkifarmstandart-Tomskhimfarm joint stock company
  • Amiksin of 60 mg No. 10 tabletkifarmstandart-Tomskhimfarm joint stock company
  • Anamiks Infantas PKU mix for children 400gnutricia Advanced Medical Nutrition

Drugstore of IFC

  • Amiksin tbl p / about 125 mg No. 10 ***, Oaorossiya's Pharmstandard-Tomskhimfarm
  • Amiksin tbl p / about 60 mg No. 10, Oaorossiya's Pharmstandard-Tomskhimfarm
  • Amiksin tbl p / about 125 mg No. 6 ***, Oaorossiya's Pharmstandard-Tomskhimfarm
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  • Amiksin tablet IS coated 0.06g No. 3interkhim (Ukraine, Odessa)
  • Amiksin tablet IS coated 0.06g No. 9interkhim (Ukraine, Odessa)
  • Amiksin tablet IS coated 0.125g No. 9interkhim (Ukraine, Odessa)
  • Amiksin tablet IS coated 0.125g No. 3interkhim (Ukraine, Odessa)
  • Vitamiks sherstevit. for dogs of the tab. No. 100


  • Amiksin tab. IS p / about 0.06g No. 3interkhim
  • Amiksin tab. IS p / about 0.06g No. 3interkhim
  • Amiksin tab. IS p / about 0.06g No. 3interkhim
  • Amiksin tab. IS p / about 0.06g No. 3interkhim


  • Amiksin KZ of 125 mg No. 10 tabl.p.o. Dalkhimfarm (Russia)
  • Amiksin KZ of 125 mg No. 6 tabl.p.o. Dalkhimfarm (Russia)
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Section: Diabetic
in more detail

Education: Graduated from the Vitebsk state medical university majoring in "Surgery". At university headed Council of students' scientific society. Professional development in 2010 - in "Oncology" and in 2011 - in "A mammology, visual forms of oncology".

Experience: Work in an all-medical network 3 years the surgeon (The Vitebsk hospital of an emergency medical service, Lioznensky TsRB) and in combination the regional oncologist and the traumatologist. Work farm the representative within a year in the Rubicon company.

Provided 3 improvement suggestions on the subject "Optimization of an Antibioticotherapia depending on Species Composition of Microflora", 2 works took prizes in a republican competition review of student's scientific works (1 and 3 categories).
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