Aminophyllinum

Аминофиллин Drug photo

The description is actual on 05.01.2015

  • Latin name: Aminophilline
  • ATH code: R03DA05
  • Active ingredient: Aminophyllinum (Aminophylline)
  • Producer: Shandong Xinhua Pharmaceutical (China)

Structure

1 ml of solution of Aminophyllinum for intravenous administration contains 24 mg of the active ingredient of the same name.

Also there are numerous forms of release in the form of ointment or cream with Aminophyllinum.

Release form

  • 5 ml of solution of drug in an ampoule, five ampoules in planimetric packaging, two or one packagings in a pack from a cardboard;
  • 5 ml of solution of drug in an ampoule, ten ampoules in planimetric packaging, two or one packagings in a pack from a cardboard;
  • 10 ml of solution of drug in an ampoule, five ampoules in planimetric packaging, two or one packagings in a pack from a cardboard;
  • 10 ml of solution of drug in an ampoule, ten ampoules in planimetric packaging, two or one packagings in a pack from a cardboard.

Pharmacological action

Vazodilatiruyushchy, diuretic, spasmolytic, bronkhodilatiruyushchy.

Pharmacodynamics and pharmacokinetics

Pharmacodynamics

Broncholitic medicine. Chemically – etilendiaminovy salt of theophylline. Has the bronkhodilatiruyushchy effect caused by the direct running-down impact on smooth muscle fibers of respiratory tracts and vessels of lungs. It is caused by the selection suppression of activity of phosphodiesterases that leads to increase in intracellular maintenance of tsAMF.

Reduces hyperreactivity of respiratory ways by means of the unknown of the mechanism so far. There are data that Aminophyllinum increases quantity and activity of T-suppressors in blood.

The mukotsiliarny clearance increases, strengthens reduction of a diaphragm, stimulates work intercostal respiratory and muscles, activates a respiratory center, improves its sensitivity and strengthens alveolar ventilation that leads to lowering of weight and frequency rate of episodes of an apnoea. Regulating respiratory function, improves saturation by oxygen of blood and lowers concentration of carbonic acid. Stimulates ventilation of the lungs against a hypopotassemia.

Exerts the activating impact on cardiac performance, increases force and frequency of heartbeat, increases a cordial blood stream and strengthens need of heart for oxygen. Lowers a tone of vessels of a brain, integuments, kidneys. Has peripheral venorasshiryayushchy action, reduces vascular resistance of lungs, reduces pressure in a pulmonary circle of blood circulation. Stimulates a renal blood stream, possesses moderate diuretic action. Expands bilious ways out of a liver.

Stabilizes walls of mast cells, slows down release of mediators of reactions of hypersensitivity. Slows down pasting of thrombocytes, increases stability of erythrocytes, lowers a thrombogenesis and regulates microcirculation.

Shows epileptogenic action in high doses.

Pharmacokinetics

In a body of the person Aminofillin it is metabolized with release of untied theophylline.

Linkng of theophylline with proteins of a blood plasma makes 40%. Drug gets through a placental barrier and is removed with breast milk.

Theophylline is transformed in a liver with the participation of a number of important enzymes of P450 cytochrome, the basic from them is CYP1A2 isoenzyme. In the course of chemical transformations 1,3-dimethyl uric acid and 3 methylxanthine are formed 1-metilmochevaya-. These derivatives are removed with urine. In an original form about 10% are brought.

Considerable specific features of speed of hepatic transformation of theophylline are the reason of strong variability of values of clearance, content in plasma, semi-removal time.

The elimination half-life at the non-smoking patients having bronchial asthma reaches 12 hours, at smokers – 4 hours, at children fluctuates from 1 to 5 hours, at newborns can proceed about two days.

Indications to use

  • Parenteral administration is used at: the asthmatic status, an apnoea of newborns, ischemic disturbance of cerebral blood circulation, the left ventricular failure (complicated with a bronchospasm and disorder of breath), hypostases of renal genesis, acute or chronic insufficiency of heart.
  • Oral administration is used at: a bronkhoobstruktivny syndrome of a various etiology (for example, bronchial asthma, emphysema of lungs, HOBL, obstructive bronchitis), a pulmonary heart, increase in pressure in a pulmonary circle of blood circulation, a night apnoea, heart failure on acute or chronic type.

Contraindications

Expressed arterial hyper - or hypotonia, stomach ulcer or a duodenum, tachyarrhythmias, severe damages of a liver or kidneys, hyperacid gastritis, epilepsy, a retinal apoplexy, a hemorrhagic stroke, sharing with ephedrine at children, age till 3 flyings, for the prolonged peroral forms age limit till 12 flyings, a sensitization to Aminophyllinum and theophylline.

Side effects

  • Reactions from TsNS: sleep disorders, dizziness, tremor, concern, spasms.
  • Reactions from the blood circulatory system: disturbances of a heart rhythm; at fast intravenous administration – developing of heartaches, pressure decrease, tachycardia, a cardialgia, aggravation of a course of stenocardia.
  • Reactions from system of digestion: gastroesophageal reflux, nausea, vomiting, heartburn, diarrhea, aggravation of a peptic ulcer, anorexia.
  • Reactions from urinogenital system: hamaturia, albuminuria.
  • Allergic reactions: itch, rash, fever.
  • Reactions from a metabolism: hypoglycemia.
  • Local reactions: a hyperemia, consolidation, morbidity in the field of an injection.
  • Other reactions: a tachypnea, a stethalgia, inflow, an albuminuria, a hypoglycemia, a hamaturia, strengthening of a daily urine, the strengthened sweating.

Application instruction of Aminophyllinum (Way and dosage)

The scheme of administration of drug more often individual, is developed depending on age, a clinical picture, indications, existence of nicotine addiction.

Perhaps intravenous or intramuscular administration. The adult enter intravenously slowly — on 240 mg one - twice a day. To children enter intravenously or intramusculary: age till 3 months — 30-60 mg, 4-12 months — 60-90 mg, 1-3 years — 90-120 mg, 4-7 years — 120-240 mg, 8-18 years — 240-480 mg a day in two-three injections.

Overdose

About cases of overdose there are no messages. If the similar state after all arose, it is recommended to stop administration of drug and to begin symptomatic therapy.

Interaction

At combined use to sympathomimetic means there is mutual an activation of pharmacological action. With drugs of lithium and beta adrenoblockers – action on the contrary is mutually weakened.

Intensity of effect of Aminophyllinum decreases at simultaneous use with Rifampicin, Phenobarbital, the Isoniazid, Sulfinpyrazonum, Carbamazepine, Phenytoinum, and also at smokers.

Force of action of Aminophyllinum can increase at simultaneous use with Linkomitsiny, hinolona, macroleads, Allopyrinolum, Cimetidinum, beta adrenoblockers, izoprenaliny, fluvoksaminy, Disulfiramum, oral contraceptives, Viloksazin and at antiinfluenzal vaccination.

Derivatives of xanthine potentsiirut the hypopotassemia caused by action of corticosteroids, agonists beta 2 - adrenoceptors and diuretics.

Antidiarrheal means and enterosorbents lower adsorption of Aminophyllinum.

Terms of sale

According to the recipe.

Storage conditions

  • to protect from children;
  • to store at a temperature up to 25 degrees.

Period of validity

Three years.

Special instructions

It is necessary to use with care drug at severe forms of coronary insufficiency, widespread atherosclerosis, frequent paroxysms of a ventricular ekstrasistoliya, hypertrophic subaortic stenosis, spasms, stomach ulcer or a duodenum, a liver or renal failure, at bleeding from bodies of a digestive tract, a gastroesophageal reflux, a hypothyroidism or a thyrotoxicosis, at a long-term hyperthermia, a prostate hypertrophy, at persons in advanced age and at children.

Analogs

Coincidence on the ATH code of the 4th level:

Aminofillin Esk, a tablet Euphyllinum, Eufillin-Darnitsa, the Euphyllinum for injections.

Section: Cardiological Cardiovascular
in more detail

Education: Graduated from the Vitebsk state medical university majoring in "Surgery". At university headed Council of students' scientific society. Professional development in 2010 - in "Oncology" and in 2011 - in "A mammology, visual forms of oncology".

Experience: Work in an all-medical network 3 years the surgeon (The Vitebsk hospital of an emergency medical service, Lioznensky TsRB) and in combination the regional oncologist and the traumatologist. Work farm the representative within a year in the Rubicon company.

Provided 3 improvement suggestions on the subject "Optimization of an Antibioticotherapia depending on Species Composition of Microflora", 2 works took prizes in a republican competition review of student's scientific works (1 and 3 categories).
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