Ampioks

Ампиокс Drug photo

The description is actual on 19.07.2016

  • Latin name: Ampiox
  • ATH code: J01CA51
  • Active ingredient: Ampicillin + Oxacillinum (Ampicillin + Oxacillin)
  • Producer: Bryntsalov-A (Russia); LLC FC Zdorovye (Kharkiv, Ukraine); Borshchagovsky HFZ (Ukriana)

Structure

In 1 capsule of Ampicillini trihdras and Oxacillinum of sodium salt on 0,125 g. Potato starch, sugar, talc, gipromelloz, magnesium stearate as excipients.

In 1 bottle of ampicillin of sodium of 133,4 mg or 333,5 mg, Oxacillinum of sodium of 66,6 mg or 166,5 mg.

Release form

Capsules of 20 pieces in packaging.

Powder in bottles.

Pharmacological action

Antibacterial.

Pharmacodynamics and pharmacokinetics

Pharmacodynamics

The antibiotic relating to semi-synthetic penicillin contains a combination of ampicillin and Oxacillinum and integrates a range of their action on microorganisms. Kislotoustoychiv, works bakteritsidno.

Shows activity in relation to gram-positive (a pneumococcus, a streptococcus, staphylococcus) and gram-negative (colibacillus, meningokokk, shigellas, gonokokk, a stick of an influenza, a salmonella) microorganisms. Presence of Oxacillinum does drug active concerning penitsillinazoustoychivy stafilokokk. Pseudomonas aeruginosa, many strains of Proteus vulgaris, Morganella are steady against Ampioks's action.

Pharmacokinetics

The maximum concentration in blood of both antibiotics is noted in 30-50 min. after intramuscular introduction. Both antibiotics are allocated with kidneys and partially — with bile. Cumulation at repeated introductions is not noted.

Indications to use

Contraindications

With care it is applied at children whose mothers have hypersensitivity to penicillin.

Side effects

At intake:

  • nausea, vomiting;
  • dysbacteriosis;
  • taste change;
  • liquid chair;
  • pseudomembranous coloenteritis.

At parenteral administration:

Application instruction of Ampioks (Way and dosage)

Drug has two dosage forms.

Tablets of Ampioks, application instruction

Capsules of Ampioks Health are accepted inside. For adults and children of 14 years a single dose of 0,5-1,0 g (2-4 capsules) which is accepted 4 times a day, thus a daily dose — 2-4 g. To children at the age of 7-9 flyings appoint 1,25 g a day, 10-14 years – 1,75 g a day. Duration of treatment depends on a disease and makes from 7 days to 2 weeks.

Ampioks's pricks, application instruction

Before purpose of injections of this drug it is necessary to define sensitivity of microflora to it. Ampioks-natry, intended for injections, enter intramusculary or intravenously, having dissolved powder in water for injections.

Single dose for adults — 0,5-1,0 g, enter it 4 times a day in 6 — 8 h. If necessary the dose increases by 1,5-2 times. Newborn appoint 100-200 mg to weight kg a day. Course of treatment from 7 to 21 days.

For intravenous administration drug is dissolved in 15 ml of normal saline solution and slowly entered. For intravenous drop use dissolve in 200 ml of physical solution. At drop introduction to children apply 5% glucose solution in number of 30-100 ml. Solutions use at once. Intravenously enter 5-7 days, if necessary pass to intramuscular introduction.

Overdose

At use of high doses for patients with a renal failure there is a probability of toxic action on TsNS. Symptomatic therapy is carried out.

Interaction

Slow down absorption and the following drugs reduce its degree: glycosamine, antacids, purgatives, aminoglycosides, and also meal. Ascorbic acid strengthens absorption of active agents. Antibiotics rifampicin, aminoglycosides, Vancomycinum, cephalosporins have sinergidny effect. And macroleads, streptocides, chloramphenicol, tetracyclines, linkozamida — antagonistic.

Ampioks strengthens effects of anticoagulants, reduces action of oral contraceptives. Diuretics, Allopyrinolum, NPVN, phenylbutazone, probenetsid, increase concentration of active agents in plasma that attracts risk of toxic action. At reception of Allopyrinolum the risk of emergence of rash increases.

Terms of sale

According to the recipe.

Storage conditions

Temperature is up to 25 °C.

Period of validity

3 years.

Use of drug at pregnancy

Widespread mistake is refusal of doctors of purpose of antibacterial therapy. At pregnancy, at pneumonia because of fear of negative influence of medicines on a fruit. Actually the list of the antibacterial drugs contraindicated during this period, is very limited - it is tetracyclines, streptocides, chloramphenicol, co-trimoxazole, aminoglycosides and ftorkhinolona. β-laktamny antibiotics to which Ampioks belongs and also macroleads are applied at pregnant women. These are not the toxic antibiotics which were not exerting impacts on a fruit.

Ampioks's analogs

Drug synonyms: Ampicillin + Oksatsillin-Borimed, Oksamp of a capsule, Oksamp-natry (powder), Oksampitsin, Oksamsar. Analogs — Amoxiclav, Amoxicillin.

Zdravzona

  • Ampioks powder prigot. solution for injections of 500 mg fl. N5
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Section: Antibiotics
in more detail

Education: Graduated from Sverdlovsk medical school (1968 - 1971) as "Paramedic". Graduated from the Donetsk medical institute (1975 - 1981) as "An epidemiologist, a hygienist". Passed postgraduate study in the Central scientific research institute of epidemiology Moscow (1986 - 1989). An academic degree – the candidate of medical sciences (degree is awarded in 1989, protection – the Central scientific research institute of epidemiology Moscow). Numerous advanced training courses are studied in epidemiology and infectious diseases.

Experience: Work as the manager of department of disinfection and sterilization of 1981 - 1992. Work as the manager of department of especially dangerous infections of 1992 - 2010. Teaching activity at Medical institute 2010 - 2013.

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