Andante

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The description is actual on 10.02.2015

  • Latin name: Andante
  • ATH code: N05CF03
  • Active ingredient: Zaleplon (Zaleplon)
  • Producer: GEDEON RICHTER (Hungary)

Structure

One capsule of drug of the Andante may contain 5 or 10 mg of a zaleplon.

Additional substances: sodium lauryl sulfate, silicon dioxide, indigo carmine, microcrystallic cellulose, titanium dioxide, magnesium stearate, starlak.

Structure of a gelatinous capsule: titanium dioxide, indigo carmine, gelatin.

Release form

Gelatinous solid capsules of blue color, light blue powder contains inside.

  • 7 capsules on 5 mg in the blister — one or two blisters in a pack from a cardboard;
  • 7 capsules on 10 mg in the blister — one or two blisters in a pack from a cardboard.

Pharmacological action

Somnolent action.

Pharmacodynamics and pharmacokinetics

Pharmacodynamics

The hypnagogue from pirazolo-pirimidinovy group, differs on chemical structure from benzodiazepines and other hypnagogues. Selektivno communicates with ω1-рецепторами benzodiazepine of 1 type.

Considerably reduces backfilling time, extends dream time, does not change a ratio of different phases of a dream. When using in the recommended doses does not cause tolerance. Renders sedative, weak anksiolitichesky, anticonvulsant and systemic myorelaxation action.

Interacts with benzodiazepine receptors of the GABA complexes of A-type. It leads to opening of ionoformny neyronalny channels for chlorine molecules, to emergence of hyperpolarization and stimulation of processes of braking in a head brain.

Pharmacokinetics

After the use about 71% of the accepted dose quickly are absorbed from intestines. Time of approach of the maximum concentration in blood — one hour. Absolute bioavailability approaches 30%. Concentration in plasma of a dozozavisim. Meal brakes time of achievement of the greatest concentration, without influencing drug absorption.

Linkng with plasma proteins for 60%. It is capable to be removed with breast milk. It is transformed in a liver with formation of inactive derivatives. The elimination half-life of a zaleplon makes about 1 hour. It is allocated in the form of inactive derivatives with kidneys (71%) and through intestines (17%).

Indications to use

The heavy types of sleep disorders leading to strong fatigue both complicating activity and worsening working capacity during wakefulness.

Contraindications

  • Night apnoea.
  • Severe forms of a liver failure.
  • Severe forms of respiratory insufficiency.
  • Heavy myasthenia.
  • Pregnancy or lactation.
  • Age less than 18 years.
  • Sensitization to drug components.

It is necessary to appoint with care the Andante at a renal or liver failure, chronic respiratory insufficiency, tendency to medicinal dependence, alcoholism, a depression.

Side effects

  • Reactions from digestion: vomiting, abdominal pain, nausea, diarrhea.
  • Reactions from nervous activity: weakness, a headache, drowsiness, an ecmnesia, dizziness, a depression, concern, aggression, excitability, paresthesias, dreadful dreams, attacks of rage, a hallucination, a behavior disorder, psychosis, emergence of physical dependence even when using in therapeutic doses, a withdrawal, emergence of mental dependence, a tremor, an ataxy, irritability, change of perception. In especially hard cases emergence of signs of an autoaggression, epileptic seizures, decrease in hearing, depersonalization, supersensitivity on light, sound and other physical irritants is possible.
  • Allergic reactions: rash on skin, an itch.

Application instruction of the Andante (Way and dosage)

Duration of therapy should not be more than two weeks. Drug is recommended to be accepted inside before going to bed and in two hours after food.

The recommended dose for persons of adult age makes 10 mg. The greatest day dose makes 10 mg. The elderly patient of a tablet of the Andante appoint 5 mg (because of hypersensitivity to hypnagogues).

At not severe forms of a liver failure the daily dose equals 5 mg (because of slow evacuation from an organism).

At not severe forms of a renal failure of correction of a dosage it is not required.

Overdose

Overdose does not cause states, life-threatening if drug was not accepted together with other medicines suppressing nervous activity. In case of overdose it is necessary to remember probability of the combined poisoning always.

Overdose signs: confusion of consciousness, the drowsiness reaching a coma a lethargy, an ataxy, breath disturbance, pressure decline, cases with death are rare.

Therapy: Flumazenil it is possible to use as an antidote, a gastric lavage during the first hours of reception, purpose of absorbent carbon, control of respiratory and cordial activity.

Interaction

Simultaneous use of neuroleptics, other hypnotic drugs, sedative, anksiolitichesky, antiepileptic, antidepressive, antihistamines, drugs for anesthesia, analgetics of opioid type leads to stimulation of sedative effect of drug.

At combined use with analgetics of opioid type development of euphoric effect of reception of the last is possible that can cause medicinal dependence.

At combined use with Cimetidinum the maintenance of a zaleplon in blood increases almost twice.

At simultaneous use with the selection blockers of CYP3A4 (Erythromycin, Ketokonazol) concentration of a zaleplon in blood also increases.

At combined use with CYP3A4 stimulators (Carbamazepine, Rifampicin, fenobarbitalopodobny means) suppression of efficiency of a zaleplon is possible.

Drug does not influence pharmacokinetics and a pharmacodynamics of Warfarin and Digoxin.

Terms of sale

Purchase strictly according to the recipe is possible.

Storage conditions

To protect from children. To store at a temperature of 16-30 degrees in an original packing.

Period of validity

2 years.

Special instructions

The patient has to be warned that drug does not serve as means for long therapy and emergence of a withdrawal after the end of its use is possible. The reception course should not exceed two weeks at all.

Drug is allowed for use at patients of advanced age.

After the termination of use of benzodiazepinopodobny drugs there is a possibility of emergence of temporary symptoms of sleeplessness, and also other accompanying reactions (alarm, change of mood, concern).

During use of the Andante consults to abstain from control of mobile mechanisms.

Analogs

Coincidence on the ATH code of the 4th level:

Selofen, Zopiklon, Somnol, Sonnat, Sonovan and others.

Zdravzona

  • Andante of 10 mg No. 7 kapsulygedeon Richter

Drugstore of IFC

  • Andante kaps 10 mg No. 7, Gedeon Richtervengriya
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Apteka24

  • Andantegedeon Richter (Hungary)
  • Andantegedeon Richter (Hungary)

Paniapteka

  • Andante kaps.10mg. No. 7

BIOSPHERE

  • Andante of 10 mg No. 7 kaps.
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Section: For a nervous system
in more detail

Education: Graduated from the Vitebsk state medical university majoring in "Surgery". At university headed Council of students' scientific society. Professional development in 2010 - in "Oncology" and in 2011 - in "A mammology, visual forms of oncology".

Experience: Work in an all-medical network 3 years the surgeon (The Vitebsk hospital of an emergency medical service, Lioznensky TsRB) and in combination the regional oncologist and the traumatologist. Work farm the representative within a year in the Rubicon company.

Provided 3 improvement suggestions on the subject "Optimization of an Antibioticotherapia depending on Species Composition of Microflora", 2 works took prizes in a republican competition review of student's scientific works (1 and 3 categories).
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