And whether you know...
Trimetazidina dihydrochloride, MKTs, gipromelloza, silicon dioxide colloid, magnesium stearate, Opadry II.
Tablets of 35 mg with the modified release, biconvex, a round form, coated in a blister strip packaging on 10 tablets in a cardboard pack No. 30.
Anti-anginal, the cytoprotective, anti-hypoxemic, metabolic.
Pharmacodynamics and pharmacokinetics
Drug due to the anti-hypoxemic action optimizes functions of cells of a myocardium and neurons of a brain, improving their metabolism. Cytoprotective action is based on strengthening of an energy potential and rationalization of consumption of oxygen, as a result of activation of oxidizing processes. Improves contractility of a myocardium, slows down process of intracellular exhaustion of phosphocreatinine and adenosine triphosphoric acid.
At acidosis normalizes function of membranes of ion channels, concentration of potassium ions in cells, interferes with accumulation in cardiomyocytes of sodium and calcium. Reduces the content of phosphates and intracellular acidosis.
Interferes with negative action of free radicals, increases electric potential, keeps integrity of cellular membranes and deactivates neutrophils in an ischemia zone. As a result of it expressiveness of injuries of a myocardium at ischemia considerably decreases. Drug reduces the frequency of stenokardichesky attacks. Resistance to an exercise stress increases, differences of the ABP are stopped.
Trimetazidin after intake is quickly and completely absorbed in a gastrointestinal tract. The maximum concentration in blood is reached in five hours. Bioavailability of drug — 90%. Poorly contacts blood proteins (16%). Gets through gistogematichesky barriers. The removal period is removed about six hours in not changed look mainly by kidneys.
Indications to use
- in complex treatment of an ischemic heart disease, including, prevention of attacks of stenocardia;
- chorioretinal vascular disorders;
- ischemic kokhleovestibulyarny syndromes (sonitus, dizziness, hearing disorder).
Contraindications Angiozila Retard
Hypersensitivity to drug, deficit of lactase, a renal failure, liver diseases, a lactose intolerance, age till 18 flyings, pregnancy, the lactation period.
- dyspepsia, abdominal pain, nausea, vomiting, diarrhea;
- headache, dizziness, adynamy;
- the itch, skin rash, is more rare — the small tortoiseshell;
- rushes of blood to the person, orthostatic hypotension.
Angiozil Retard, application instruction (Way and dosage)
To accept on one tablet twice a day during meal. Duration of administration of drug is defined by the doctor.
Data are absent.
The expressed clinical effects of interaction of drug with other HP are not revealed.
Terms of sale
According to the recipe.
At a temperature up to 25 °C. List B
Period of validity
Analogs Angiozila Retard
Coincidence on the ATH code of the 4th level:
About Angiozile Retard
About drug significantly differ, for example:
- "… I have an ischemic disease, appointed many drugs. Angiozil Retard was one of the most effective. The number of attacks was reduced. The health improved.";
- "… I have ischemia long ago, drank various drugs, also Angiozil Retard — drug tried though has positive effect, but considerably concedes to Preduktal, Trimektal and Prekardu".
According to doctors, as a result of reception Angiozil Retard by ischemic heart disease patients with disturbances of a cordial rhythm twice a day in a dose of 35 mg in a combination with anti-anginal therapy for one month the quantity of ventricular extrasystoles and episodes of a supraventricular Bouveret's disease authentically decreased.
/a class='other-apteks-link link01'>to show still
PAY ATTENTION! Information on drugs on the website is help generalizing, collected from public sources and can form the basis for making decision on use of medicines it is not aware of treatment. Before medicine use Angiozil Retard surely consult with the attending physician.