Angiozil Retard

Ангиозил Ретард Drug photo

The description is actual on 16.03.2016

  • Latin name: Angiozil Retard
  • ATH code: C01EB15
  • Active ingredient: Trimetazidin (Trimethazidinum)
  • Producer: Replekpharm AD (Republic of Macedonia)

Structure

Trimetazidina dihydrochloride, MKTs, gipromelloza, silicon dioxide colloid, magnesium stearate, Opadry II.

Release form

Tablets of 35 mg with the modified release, biconvex, a round form, coated in a blister strip packaging on 10 tablets in a cardboard pack No. 30.

Pharmacological action

Anti-anginal, the cytoprotective, anti-hypoxemic, metabolic.

Pharmacodynamics and pharmacokinetics

Pharmacodynamics

Drug due to the anti-hypoxemic action optimizes functions of cells of a myocardium and neurons of a brain, improving their metabolism. Cytoprotective action is based on strengthening of an energy potential and rationalization of consumption of oxygen, as a result of activation of oxidizing processes. Improves contractility of a myocardium, slows down process of intracellular exhaustion of phosphocreatinine and adenosine triphosphoric acid.

At acidosis normalizes function of membranes of ion channels, concentration of potassium ions in cells, interferes with accumulation in cardiomyocytes of sodium and calcium. Reduces the content of phosphates and intracellular acidosis.

Interferes with negative action of free radicals, increases electric potential, keeps integrity of cellular membranes and deactivates neutrophils in an ischemia zone. As a result of it expressiveness of injuries of a myocardium at ischemia considerably decreases. Drug reduces the frequency of stenokardichesky attacks. Resistance to an exercise stress increases, differences of the ABP are stopped.

Pharmacokinetics

Trimetazidin after intake is quickly and completely absorbed in a gastrointestinal tract. The maximum concentration in blood is reached in five hours. Bioavailability of drug — 90%. Poorly contacts blood proteins (16%). Gets through gistogematichesky barriers. The removal period is removed about six hours in not changed look mainly by kidneys.

Indications to use

  • in complex treatment of an ischemic heart disease, including, prevention of attacks of stenocardia;
  • chorioretinal vascular disorders;
  • ischemic kokhleovestibulyarny syndromes (sonitus, dizziness, hearing disorder).

Contraindications Angiozila Retard

Hypersensitivity to drug, deficit of lactase, a renal failure, liver diseases, a lactose intolerance, age till 18 flyings, pregnancy, the lactation period.

Side effects

  • dyspepsia, abdominal pain, nausea, vomiting, diarrhea;
  • headache, dizziness, adynamy;
  • the itch, skin rash, is more rare — the small tortoiseshell;
  • rushes of blood to the person, orthostatic hypotension.

Angiozil Retard, application instruction (Way and dosage)

To accept on one tablet twice a day during meal. Duration of administration of drug is defined by the doctor.

Overdose

Data are absent.

Interaction

The expressed clinical effects of interaction of drug with other HP are not revealed.

Terms of sale

According to the recipe.

Storage conditions

At a temperature up to 25 °C. List B

Period of validity

4 years.

Analogs Angiozila Retard

Anti-walls, Deprenorm of MV, Vero-Trimetazidin, Preduktal, Medarum 20, Trimetazid, Trimet, Trimektal, Trimetazidin, Rimekor and others.

About Angiozile Retard

About drug significantly differ, for example:

  • "… I have an ischemic disease, appointed many drugs. Angiozil Retard was one of the most effective. The number of attacks was reduced. The health improved.";
  • "… I have ischemia long ago, drank various drugs, also Angiozil Retard — drug tried though has positive effect, but considerably concedes to Preduktal, Trimektal and Prekardu".

According to doctors, as a result of reception Angiozil Retard by ischemic heart disease patients with disturbances of a cordial rhythm twice a day in a dose of 35 mg in a combination with anti-anginal therapy for one month the quantity of ventricular extrasystoles and episodes of a supraventricular Bouveret's disease authentically decreased.

Zdravzona

  • Angiozil retard 35 mg No. 60 tabletkireplekfarm/Soteks
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Section: Cardiological Cardiovascular
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Education: Graduated from Sverdlovsk medical school (1968 - 1971) as "Paramedic". Graduated from the Donetsk medical institute (1975 - 1981) as "An epidemiologist, a hygienist". Passed postgraduate study in the Central scientific research institute of epidemiology Moscow (1986 - 1989). An academic degree – the candidate of medical sciences (degree is awarded in 1989, protection – the Central scientific research institute of epidemiology Moscow). Numerous advanced training courses are studied in epidemiology and infectious diseases.

Experience: Work as the manager of department of disinfection and sterilization of 1981 - 1992. Work as the manager of department of especially dangerous infections of 1992 - 2010. Teaching activity at Medical institute 2010 - 2013.

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