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Nimesulide, hydroxypropyl cellulose, sodium docusate, monohydrate of lactose, glikolit starch sodium, microcrystallic cellulose, the hydrogenated vegetable oil, magnesium stearate.
Tablets of 100 mg of a round form, flat, white color in blister strip packagings on 10 pieces in a cardboard pack No. 20.
Antiinflammatory, analgetic, antipyretic.
Pharmacodynamics and pharmacokinetics
Treats group of the selection TsOG-2 inhibitors (cyclooxygenase-2). Drug has analgeziruyushchy, antiinflammatory and febrifugal effect. The mechanism of action is based on reduction in the center of an inflammation of synthesis of prostaglandins, and also in a hypothalamus. In kidneys and a mucous membrane of a stomach drug practically does not influence synthesis of prostaglandins, than its good tolerance speaks. Drug oppresses process of peroxide oxidation of fats and education of free radicals, reduces development of a factor of activation of thrombocytes, release of a histamine, factor of an inflammation, proteinases and other mediators of an inflammation.
Drug is well soaked up from a gastrointestinal tract, meal reduces the speed of absorption. In an organism does not kumulirut. Therapeutic concentration of drug in blood is defined in 2 hours and is maintained for 8 hours. An elimination half-life — 3 hours. Biotransformation occurs in a liver to level pharmacological active (hydroxynimesulide) and inactive metabolites. It is removed through kidneys and intestines.
Indications to use
High sensitivity to drug, aggravations of cankers of a gastrointestinal tract, a renal failure, bleeding in a gastrointestinal tract, a liver failure, the III trimester of pregnancy, a lactation, medicinal dependence, alcoholism, fervescence, age till 12 years, blood coagulation disturbances.
Dizziness, headache, drowsiness, pains in a stomach, heartburn, an ulceration mucous a gastrointestinal tract, nausea, diarrhea, hypostases, an oliguria, a hamaturia, an agranulocytosis, thrombocytopenia, local and general allergic reactions.
Aponil, application instruction (Way and dosage)
For adults the single dose varies from 50 to 200 mg, maximum — 400 mg a day. About 1 tablet after food 2 times a day is accepted, it is washed down with water. A dosage for children — 1,5 mg/kg (the maximum dose — 5 mg/kg a day).
In rare instances nausea and vomiting.
At a concomitant use of drug with indirect anticoagulants the risk of strengthening of their action increases. At the combined reception with lithium salts their concentration in a blood plasma increases. Nimesulide is competitively forced out from communication with proteins by gipoglikemiziruyushchy means, acetylsalicylic acid, streptocides, cyclosporine, foxglove drugs, a methotrexate.
Terms of sale
At a temperature up to 25 °C.
Period of validity
Coincidence on the ATH code of the 4th level:
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About drug at most of patients favorable. Especially often note its high performance at treatment of arthritises, miozit, a tendovaginitis. "… Made me the diagnosis a humeroscapular periarthritis. Function of a shoulder suffered and severe pains in a shoulder developed, then the shoulder muscle tendovaginitis joined. In treatment used many drugs including tablets Aponil which well stopped pain".
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