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In 1 tablet of an anastrozol of 1 mg.
Lactoses monohydrate, karboksimetilenkrakhmat sodium, povidone, magnesium stearate, water as auxiliary components.
Tablets in a cover No. 28.
Pharmacodynamics and pharmacokinetics
The high-selection inhibitor of aromatase — enzyme by means of which in a postmenopause androstendion in fabrics turns into oestradiol. Decrease in its level renders therapeutic effect at a breast cancer. It is established that the dose of 1 mg reduces its level by 80%.
Does not possess androgenic, progestogenny and oestrogenic action. Even in doses to 10 mg does not influence secretion of cortisol and Aldosteronum therefore replaceable treatment by corticosteroids is not carried out.
Causes changes in a bone tissue which are prevented by the purpose of bisfosfonat especially sick with average and high risk of osteoporosis and changes.
Drug does not cause changes of level of lipids in blood.
Absorption happens quickly and the maximum concentration is defined in 2 hours after reception of a tablet. Meal does not reduce extent of absorption therefore does not influence concentration of drug in plasma. After week reception 90-95% of equilibrium concentration are reached. For 40% contacts blood proteins. It is removed slowly, T1/2 makes 40-50 hours. Within 72 hours okolo10 the % of a dose is allocated with urine. The clearance of an anastrozol does not change at cirrhosis and renal failures. The main metabolite triazole — does not inhibit aromatase.
Indications to use
- auxiliary treatment of an early breast cancer in a postmenopause;
- auxiliary treatment of an early breast cancer after treatment by Tamoxifenum;
- widespread breast cancer in a postmenopause.
- cancer in a premenopauza;
- pregnancy and period of feeding by a breast;
- the expressed liver and renal failure;
- use of Tamoxifenum or estrogen of the containing drugs;
- children's age.
With care it is applied at osteoporosis, an ischemic heart disease, a hypercholesterolemia, an abnormal liver function, glyukozo-galaktozny malabsorption, insufficiency of lactase.
The met side reactions are more often:
- arthralgia and constraint of joints;
- the easy or moderately expressed adynamy;
- nausea, vomiting;
- dryness mucous vaginas;
- uterine bleedings (after drug withdrawal);
- skin rash;
- thinning of hair;
- allergic reactions;
- syndrome of a carpal tunnel (with risk factors of this disease);
- increase of activity of enzymes of a liver;
- decrease in mineral density of a bone and risk of developing of osteoporosis.
The met side reactions are more rare:
- trigger finger;
- small tortoiseshell;
- erythema, vasculitis;
- Stephens-Johnson's syndrome;
- Quincke's edema;
Arimideks, application instruction (Way and dosage)
Pill is taken inside entirely, in one and too time. The dose — 1 mg of 1 times a day, treatment is carried out is long. At adjuvant therapy — 5 years. At lungs and moderately expressed renal failures at patients dose adjustment is not carried out. Also it is not required at easy degree of an abnormal liver function.
The application instruction of Arimideks contains the warning that in the presence of uterine bleeding at administration of drug consultation of the gynecologist is necessary. When progressing a disease administration of drug is stopped.
The adynamy and drowsiness as side reactions, can negatively influence performance of work, the demanding concentration of attention and speed of reactions, and also on an opportunity to steer vehicles.
The single dose which can lead to states, life-threatening is not established. As there is no specific antidote, the symptomatic treatment and control of function of vitals is carried out.
It is known that estrogensoderzhashchy drugs reduce effect of active agent.
Tamoxifenum also weakens pharmacological action of an anastrozol.
Terms of sale
It is released according to the recipe of the doctor.
Temperature of storage is up to 30 °C.
Period of validity
In 1997 aromatase inhibitors letrozole and arimideks which was more effective remedy for prevention of recurrence of a breast cancer, in comparison with Tamoxifenum which is "the gold standard" among drugs passed clinical tests.
This drug increases survival level to 63% in comparison with therapy by Tamoxifenum. The risk of recurrence of tumors decreases by 32%. It is convenient in use that is noted in responses, and causes side effects in comparison with inhibitors of aromatase of the previous generations much less often. Use of this drug during 5 flyings was more effective, than use of Tamoxifenum during the same time. Besides, transition to it after 2 flyings of reception of Tamoxifenum is more effective too if to compare to reception of one Tamoxifenum within 5 years and such transition is justified. But, in comparison with Tamoxifenum, it causes undesirable reactions in the form of osteoporosis, joint pains and pathological changes more often.
All these moments reflect About Arimideks:
- "… Awfully transferred — bones and joints therefore moved with a stick hurt, inflow of heat and perspiration tormented";
- "… Transferred to reception of this drug after Tamoxifenum as it was inefficient in my case";
- "… I had such scheme: Tamoxifenum 3 years, then aromatase inhibitors";
- "… I can tell nothing bad about Tamoxifenum as accepted it 5 years, then transferred to aromatase inhibitors which 5 years are going to accept too".
Many note good tolerance of drug for many years. For some it was unacceptable.
There is an opinion that Arimideks is more effective than Femara though researches were not conducted.
According to oncologists, Zoladeks and Arimideks's use in a combination gives lasting effect in certain cases for years.
Efficiency of a combination of Arimideks and Faslodeks is studied.
The combination to Tamoxifenum is not applied as it does not lead to efficiency increase, and expressiveness of side reactions amplifies.
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