To Arpefl

Арпефлю Drug photo

The description is actual on 02.08.2016

  • Latin name: Arpeflu
  • ATH code: J05AX
  • Active ingredient: Метилфенилтиометил-диметиламинометил-гидроксиброминдол carboxylic acid ethyl ether (Methylphenylthiomethyl-dimethylaminomethyl-hydroxy-bromindol carboxylic acid ethyl ester)
  • Producer: Lekfarm of SOOO (Belarus)

Structure

In 1 tablet of an umifenovir of a hydrochloride of 50 or 100 mg. MKTs, magnesium the stearate, starch modified povidone, lactoses monohydrate, silicon dioxide, Opadry II, polyvinyl alcohol, talc as excipients.

Release form

Tablets in a cover of 50 and 100 mg.

Pharmacological action

Antiviral, immunomodulatory.

Pharmacodynamics and pharmacokinetics

Pharmacodynamics

Drug to Arpefl is antiviral drug for system use. Contains active agent umifenovir (arbidol) which suppresses influenza viruses And yes Century. Specific action is connected with oppression of merge of a cover of viruses to covers of cells — thus their penetration into organism cells is prevented. Also arbidol influences increase in products of interferon. Treats low-toxic drugs. At use it reduction of terms of an illness, decrease in weight of flu and SARS and frequency of complications is noted.

Pharmacokinetics

At intake it is quickly and completely soaked up and the maximum concentration in blood are created in 1,5 hours. In a liver there is a metabolism of active agent. The insignificant part kidneys is allocated with intestines in an invariable look also. The elimination half-life of 17-20 hours, is within a day removed about 90% of a dose.

Indications to use

In complex treatment it is applied at:

  • flu;
  • The SARS complicated by pneumonia and bronchitis;
  • recurrent herpes infection;
  • secondary immunodeficiency;
  • the acute intestinal infections caused by a rotavirus.

Prevention of a SARS and flu.

Contraindications

  • intolerance and hypersensitivity;
  • age till 3 flyings;
  • lactose intolerance.

Side effects

In rare instances allergic reactions at the patients having individual intolerance.

To Arpefl, application instruction (Way and dosage)

Pill Arpeflya is taken before food, washing down with a large amount of liquid. Schemes of treatment depend on disease severity and are defined by the doctor. Duration treatment is also adjusted by the doctor depending on dynamics of a disease and the accompanying pathology.

Single dose for adults and children of 12 flyings — 200 mg. Flu and a SARS — 200 mg 4 times a day. Duration of reception is up to 5 days. At the flu complicated by pneumonia, 200 mg 4 times a day 5 days, and then once a week, month.

Recurrent herpes infection of 200 mg 4 times a day 7 days, with transition to reception of 200 mg twice a week within a month. Preventive reception after contact with the patient — 200 mg of 1 times a day 10-14 days. At epidemic — 200 mg 2 times a week 3 weeks.

To Arpefl for children from 3 to 6 years it is recommended in a dose of 50 mg and 100 mg from 6 to 12 flyings. At rotavirusny intestinal infection — the single dose according to age is accepted 4 times a day.

Overdose

Cases of overdose are not known. At reception of the overestimated doses emergence of undesirable effects is possible.

The specific antidote does not exist. Carry out a symptomatic treatment.

Interaction

It is contraindicated to accept with alcohol. At appointment with other medicines of interaction it was not noted.

Terms of sale

Without recipe.

Storage conditions

Temperature is up to 20 °C.

Period of validity

2 years.

Analogs Arpefl

Immustat, Arbidol, LENS Arbidol, Arbivir, ORVITOL of NP, Arbimaks.

About Arpeflya

The SARS and flu are widespread group of infectious diseases. Often have a heavy current and failures. One of the reasons of it is reduced immunity. Therefore use of antiviral drugs, at the same time being inductors of formation of endogenous interferon and immunomodulators is actual. One of such drugs is to Arpefl. It is especially actual for children as they have the raised susceptibility to viral infections and an insufficient immune response that causes long disease. If to compare this drug to Amantadin and Remantadinum, then their action spectrum narrow — affect only an influenza virus And yes at their reception side effects are possible.

This drug possesses direct action on influenza viruses And yes Century. Use to Arpefl is also effective at a herpes and rotavirusny infection. Existence at it provides to interferonindutsiruyushchy, immunomodulatory and antioxidant activity high performance at treatment and prevention of viral diseases, prevents complications and exacerbations of the accompanying chronic pathology. Drug is well transferred, we will combine with antibiotics if in their reception there is a need. All these moments are reflected in responses.

  • "… My experience of reception of this drug positive — facilitates flu symptoms, there is a recovery quicker".
  • "… Helped me and in 3 days there is no hint left also about cold".
  • "… Applied all family during a flu epidemic, I consider that therefore were not ill".
  • "… Very much this drug was pleasant. Quickly put the little son on legs — all signs left by the end of day".
  • "… Accepted at flu, it is very happy as the effect was available".
  • "… I consider that it helps. The husband got sick, temperature was 39. Accepted only antiviral Arpeflya and Nimesil. In three days put himself on legs and came to work".
  • "… Me appointed at an aggravation of a chronic purulent bronchitis together with antibiotics, transferred well. Recovered quicker, than usually".
  • "… An inexpensive and effective remedy from flu".
  • "… Helped me in one day! The good assistant during a season of colds".
  • "… Helps to overcome quickly flu".
  • "… I increased pressure after its reception".
  • "… The child is healthy, but in group a half of children is ill. To Dai Arpefl, that did not ache".

It is the most reasonable to use drug at preventive actions before rise in incidence of flu and SARS in the fall. Its high performance remains 2-3 months. According to supervision, after carrying out a preventive course the number of children, sick SARS, by 1,4 times was less. A sign of efficiency is also decrease in frequency of a SARS at adults with chronic respiratory diseases.

Zdravzona

  • To Arpefl of 100 mg No. 30 tabletkilekfarm Ltd company
  • To Arpefl of 100 mg No. 10 tabletkilekfarm Ltd company
  • To Arpefl of 100 mg No. 20 tabletkilekfarm Ltd company
  • To Arpefl of 50 mg No. 20 tabletkilekfarm Ltd company
  • To Arpefl of 50 mg No. 10 tabletkilekfarm Ltd company
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  • To Arpefl

BIOSPHERE

  • To Arpefl of 100 mg No. 10 tabl.p.o. LLC Lekfarm (Belarus)
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Section: Immunity increase Antiviral
in more detail

Education: Graduated from Sverdlovsk medical school (1968 - 1971) as "Paramedic". Graduated from the Donetsk medical institute (1975 - 1981) as "An epidemiologist, a hygienist". Passed postgraduate study in the Central scientific research institute of epidemiology Moscow (1986 - 1989). An academic degree – the candidate of medical sciences (degree is awarded in 1989, protection – the Central scientific research institute of epidemiology Moscow). Numerous advanced training courses are studied in epidemiology and infectious diseases.

Experience: Work as the manager of department of disinfection and sterilization of 1981 - 1992. Work as the manager of department of especially dangerous infections of 1992 - 2010. Teaching activity at Medical institute 2010 - 2013.

PAY ATTENTION! Information on drugs on the website is help generalizing, collected from public sources and can form the basis for making decision on use of medicines it is not aware of treatment. Before medicine use to Arpefl surely consult with the attending physician.