Ascorbic acid

Аскорбиновая кислота Drug photo

The description is actual on 03.06.2015

  • Latin name: Ascorbic acid
  • ATH code: A11GA01
  • Active ingredient: MNN: Ascorbic acid (Ascorbic acid)
  • Producer: JSC Borisovsky Plant of Medical Supplies, RUPP of "Belmedpreparata" Republic of Belarus JSC Marbiofarm, Russia Kiev vitamin plant, LLC Pharmaceutical Company Zdorovye, Ukraine

Structure

Ascorbic acid, starch syrup, sugar, talc, light mineral oil, wax yellow, E104 dye (quinolinic yellow), "orange flavor" fragrance are a part of a dragee.

Structure of a r/r for in/in and introductions in oil: ascorbic acid (0,05g/ml or 0,1 g/ml), bicarbonate and sodium sulfite, the water saturated with carbon dioxide for and.

Ascorbic acid, dextrose, sugar, potato starch, additive of E470 (calcium stearate), fragrance are a part of tablets (a strawberry/raspberry/cranberry / wild berries).

Tablets for chewing contain ascorbic acid, refined sugar, magnesium stearate, aspartame, microcrystallic cellulose, orange fragrance, a gipromelloza, dye yellow E110 ("Sunset") or beta carotene.

Release form

  • The dragees packaged on 50, 100 or 200 pieces in bottles from polymeric materials / glass jars or on 10 pieces in blister strip packagings on 5 packagings in a cardboard pack.
  • R/r for in/in and introductions of 5 and 10% in oil in ampoules of 1, 2 and 5 ml, on 10 ampoules in a cardboard box.
  • Lyophilisate for preparation of a r/r for in/in and introductions in oil. Dosage of 0,05 g. Drug is issued in ampoules, on 5 ampoules in a pack from a cardboard complete with solvent (water for and — 2 ml).
  • Powder for preparation of a r/r for reception of per os. Dosage of 1 and 2,5 g; it is implemented in the paper bags laminated by PE.
  • The tablets packaged on 50 pieces in banks from glass.
  • Chewable tablets in packaging No. 30.

Pharmacological action

Vitamin drug. Ascorbic acid in pure form.

Pharmacodynamics and pharmacokinetics

Drug possesses activity of vitamin C. Has metabolic effect, regulates reactions of oxidation recovery and transport of hydrogen in a large number of biochemical reactions, improves use of glucose in a citrate cycle, accelerates an angenesis, takes part in formation of H4 folate, collagen and steroid hormones.

Maintains normal permeability of capillary walls and a colloidal state of an extracellular matrix. Activates proteases, participates in an exchange of cholesterol, pigments and aromatic amino acids, promotes deposition of a glycogen in a liver.

Due to activation of tsitokhrom of a liver increases its belkovoobrazovatelny and detoksikatsionny activity, and also synthesis of a prothrombin. Recovers incretory function of a thyroid gland and vneshnesekretorny — a pancreas, stimulates department of bile.

Regulates an immune responsiveness (activates production of interferon, antibodies, components of system of a complement C3), promotes phagocytosis and strengthening of immunity.

Has antiallergic effect and stops inflammatory processes. Oppresses development of mediators of an anaphylaxis and inflammation (including, prostaglandins), slows down emission of a histamine and accelerates its degradation.

As in a human body vitamin C is not produced, its insufficient quantity in food provokes hypo - and Page avitaminosis.

Standard daily rate for men — 0,07-0,1 g, for women — 0,08 g. During pregnancy the requirement increases to 0,1 g, at a lactation — to 0,12 g. Children and teenagers depending on age should accept from 0,03 to 0,07 g of vitamin C.

It is soaked up in a small intestine: at reception less than 0,2 g are absorbed about 2/3 of the accepted dose; at increase of a dose absorption decreases to 50-20%.

Concentration of ascorbic acid at reception of per os reaches a maximum in 4 hours.

Substance easily gets into thrombocytes and leukocytes, and in an effect — into all fabrics; it is deposited in a bast layer of adrenal glands, a back share of a hypophysis, intestinal walls, muscular tissue, a brain, ovaries, intersticial cells of seminal glands, an eye epithelium, a spleen, a liver, kidneys, lungs, pancreatic and thyroid glands, heart.

It Biotransformirutsya mainly in a liver.

The ascorbate and its metabolites (diketogulonic and oxalacetic acids) are excreted with urine and contents of intestines, and also allocated with breast milk and a secret of sweat glands.

Indications to use

Use of drug is reasonable at:

  • hypovitaminosis With;
  • capillary toxicosis;
  • hemorrhagic diathesis;
  • hemorrhagic stroke;
  • infectious diseases;
  • bleedings (including nasal, uterine, pulmonary);
  • idiopathic megemoglobinemiya;
  • liver pathologies (including chronic hepatitis, an infectious disease, cirrhosis);
  • acute radial illness;
  • complications of infusion-transfusion therapy;
  • diseases of a digestive tract (including enteritis, colitis, a peptic ulcer, an akhiliya);
  • Addison's diseases (hypocorticoidism);
  • cholecystitis;
  • the parasitic diseases caused by helminths;
  • difficult healing wounds, burns, fractures, ulcers;
  • intellectual and physical overworks;
  • pregnancies;
  • lactations;
  • states which are followed by excess adjournment in hemosiderin body tissues;
  • eritro-and melanodermas;
  • psoriasis;
  • chronic widespread dermatosis.

Antioxidant properties of ascorbic acid are used in treatment of bronchial asthma, atherosclerosis, infectious and a tremens, diffusion defeats of connecting fabric (hard currency, a pseudorheumatism, a scleroderma), overdose of anticoagulants, intoxication by barbiturates, streptocides, benzene, aniline, methyl alcohol, anaesthesin, carbon monoxide, a dichloroethane, Disulfiramum, cyanhydric acid, potassium permanganate, phenols, thallium, arsenic, quinine, monk's-hood.

Reception of means is also shown during recovery after diseases and surgical interventions.

Intravenously and intramusculary Ascorbic acid in ampoules is entered in situations when it is necessary to fill quickly shortage of vitamin C, and also in sitauation when oral administration is impossible.

In particular, parenteral administration is required at Addison's illness, a number of diseases of a gastrointestinal tract (at states, after a resection of a site of a small intestine and a gastrectomy, persistent diarrhea, a round ulcer).

Contraindications

Absolute contraindications:

  • hypersensitivity;
  • the diseases of veins complicated by thromboses and thrombophlebitises.

States at which Ascorbic acid is appointed with care:

  • diabetes mellitus;
  • intolerance of fructose;
  • pathologies of kidneys (in particular, an urolithiasis — at use more than 1 g a day);
  • hemochromatosis;
  • leukemia;
  • thalassemia;
  • the progressing tumoral diseases;
  • sideroblastny and drepanocytic anemia;
  • polycythemia;
  • deficit of cytosolic G6PD enzyme.

In pediatrics restriction to use of a dragee Ascorbic acid is age till 4 years for. Tablets are appointed from six-year age. Chewable tablets in pediatric practice do not use.

Side effects

From heart, vascular and hemopoietic systems: neutrophylic leukocytosis, thrombocytosis, erythropenia, giperprotrombinemiya.

From sense bodys and nervous system: weakness and dizziness (at too fast administration of ascorbic acid in/in).

From a digestive tract: at oral administration — diarrhea (at reception more than 1 g/days), irritation mucous the digestive channel, followed by nausea, diarrhea, vomiting, an erosion of an adamantine substance of tooth (at the frequent use of tablets for chewing or a rassasyvaniye of dragees/tablets).

Metabolic disturbances: disturbance of a course of exchange processes, oppression of development of a glycogen, excess formation of adrenosteroids, delay of water and Na, hypopotassemia.

From an urogenital path: increase in diuresis, formation of oxalic concrements (in particular at long reception more than 1 g a day), damage of the glomerular device of kidneys.

At introduction to a muscle morbidity in the place of a prick is possible, introduction to a vein can be followed by feeling of heat.

Substance is strong allergen and can provoke hypersensitivity reactions even when the person does not exceed the recommended daily dose.

Symptoms of an allergy to ascorbic acid are shown in the form of a hyperemia of an integument and emergence of skin rash.

Application instruction of Ascorbic acid

How to take the peroral forms of Ascorbic acid?

Dragee and a pill it is recommended to take after food. Chewable tablets before a proglatyvaniye are chewed and washed down with a small amount of drinking water.

Ascorbic acid in powder is used for preparation of drinks. For this purpose 1 g of means (approximately ⅓ a teaspoon) part in liter of water or juice.

In the preventive purposes the adult is shown to accept from 0,05 to 0,1 g/days, the daily dose for the child varies in the range from 0,025 to 0,075 g. Pregnant women and the feeding women in the first 10-15 days should accept 0,3 g/days, further the dose is reduced to 0,1 g/days.

With the medical purpose the adult depending on indications appoint to accept from 0,15 to 0,5 g/days (the dosage depends on indications). The daily dose is divided into 3-5 receptions. For children the daily dose makes from 0,1 to 0,3 g. It is necessary to divide it into 2-3 receptions. Course duration — 14 days.

Therapeutic dose of Ascorbic acid in the form of chewable tablets — 0,25 g/days. Treatment lasts from 10 to 15 days. At flu, severe cold, avitaminosis and infectious diseases the daily dose is increased by 2-4 times. To accept vitamin C in the raised dose from 7 to 10 days are allowed.

The instruction on Ascorbic acid in ampoules

Enter into ascorbic acid struyno or kapelno. The dose is selected individually depending on character and disease severity. For patients 12 years are more senior it varies ranging from 0,05 to 0,15 g. At poisonings increase of a dosage to 3 g is allowed.

For children till 12 flyings the single dose makes 5-7 mg/kg.

Duration of treatment is caused by nature of pathological process and efficiency of therapy.

The highest single dose for the adult — 0,2 g, daily — 1 g. To children the dosage is selected depending on age. As a rule, the daily dose makes:

  • before half a year — 0,03 g;
  • 6-12 months — 0,035 g;
  • 12 months are-3 years old — 0,04 g;
  • 4-10 years — 0,045 g;
  • 11-12 years — 0,05 g.

The highest daily dose for the child is younger than 12 years — 0,1 g.

Struyno solution is entered within 1-3 minutes. Kapelno the drug is slowly administered by intravenous infusion, previously having dissolved a single dose in 50-100 ml of NaCl solution of 0,9%. Rate of administering — 30-40 drops a minute.

Intramusculary Ascorbic enter deeply into a muscle.

Ascorbic acid with glucose

Ascorbic acid with glucose is appointed for prevention and treatment of infectious diseases at the weakened patients.

Preventive dose for the adult — 0,5-1 tab. / days, therapeutic — from 1,5 to 5 tab. / days. For children 5-6 years are more senior the preventive dose makes 0,5 tab. / days, therapeutic — 1-3 tab. / days.

Glucose with ascorbic acid is intravenously appointed for prevention of consecutive infection, a fluid lungs, a renal liver failure and some other pathologies. The advantage of this means is huge also for pregnant women who suffer from severe toxicosis and need additional support of an organism. In each case the dose is selected individually.

Responses demonstrate that very many people (especially the people keeping to a diet) use tablets of ascorbic acid with glucose instead of the prohibited sweets including what they are less harmful. Caloric content of glucose of 340 kcal, and contains in its one tablet 877 mg. That is 1 tablet is about 30 kcal.

However the use of drug instead of candies and regular exceeding of standard daily rate of vitamin C is fraught with serious problems with a stomach.

Overdose

Overdose by Ascorbic acid develops at long use of the doses exceeding 1 gram a day. Its signs are:

  • headache;
  • nausea;
  • sleeplessness;
  • hyperexcitability of TsNS;
  • ulceration mucous digestive channel;
  • vomiting;
  • diarrhea;
  • oppression of functional activity of the insulyarny device PZhZh;
  • nephrolithiasis;
  • oxarods;
  • hyperacid gastritis;
  • moderate pollakiuria;
  • damage of the glomerular (glomerular) device of kidneys;
  • decrease in permeability of capillary walls.

In some cases ABP and coagulability of blood raise, the trophicity of fabrics worsens, mikroangiopatiya develop.

Intravenous administration of high doses of vitamin C can provoke an erythrocytolysis and abortion.

Lethal dose of vitamin C — 20-30 grams.

Interaction

Ascorbic acid (A.k.) increases plasma concentration of salicylates, ethinylestradiol, antibiotics of a tetratsikliny row, benzylpenicillin; reduces — contraceptives for oral administration.

Absorption and assimilation A.k. it is broken at gastrointestinal tract pathologies (a diarrhea/lock, a peptic ulcer, gastritis, a lambliasis, a helminthic invasion), administration of drug with alkaline drink, and also with fresh juice from fruit and vegetables, in a combination with oral contraceptives and acetylsalicylic acid.

A.k. increases activity of noradrenaline, reduces efficiency of heparin and anticoagulants of a coumarinic row, improves absorption of iron preparations in an intestinal path.

In a combination with Deferoxaminum can provoke increase of fabric toxicity of iron (including cardiotoxicities) and to lead to development of heart failure.

Increases the general plasmatic clearance of alcohol. Influences efficiency of Disulfiramum.

Reserves of vitamin C are exhausted at long reception of calcium chloride, drugs of a quinolinic row, salicylates, corticosteroids.

Solution A.k. enters interaction with the majority of medicines when mixing in one syringe.

Terms of sale

The recipe is necessary for acquisition of solution. Other forms of release are released without recipe.

Example of the recipe on Latin for 5% solution:
Sol. Acidi ascorbinici of 5% — 1 ml
D.t.d. N.10 in amp.
S. Intramusculary on 1 ml 2 times a day.

The recipe in Latin for the tableted drug form:
Acidi ascorbinici 0,05
D.t.d. N. 50 in tabl.
S. According to 2 tab. 3 times a day after food

Storage conditions

Ascorbic acid should be stored in the place, svetozashchishchenny, hardly accessible for children, at a temperature no more than 25 °C.

Period of validity

Solution is considered suitable for use within a year, a dragee — within one and a half years after a date of issue. A period of validity for powder, lyophilisate and chewable tablets — 2 years. Ascorbic acid in tablets keeps pharmacological properties during 3 flyings.

Special instructions

In Wikipedia it is specified that vitamin C (L-ascorbic acid) is related to glucose organic compound. Its advantage for a human body is huge — vitamin carries out function of coenzyme of a number of metabolic processes, antioxidant and a reducer.

Constitutional formula of ascorbic acid:
Структурная формула аскорбиновой кислоты

According to the International Pharmacopoeia, substance has an appearance of crystal powder of almost white or white color with acid taste. It is easily dissolved to water, it is soluble in ethanol (about 750 g/l) of IR, almost insolubly in other organic solvents powder is almost insoluble. Belongs to the category of potivotsingotny means.

Vitamin C in solution quickly collapses under the influence of air; even in the svetozashchishchenny place gradually collapses in the wet atmosphere. Speed of destruction increases at temperature increase.

Ascorbic acid is present at all fabrics of the higher plants and animals. The person, unlike the majority of animals, in the course of evolution owing to a mutation lost ability to independently synthesize vitamin C, and receives it only with food stuffs.

The OKPD code for ascorbic acid (vitamin C) — 24.41.51.180. For the food industry substance is received according to GOST 4815-76.

Quantitative definition of substance

Methods of quantitative definition A.k. are based on its expressed recovery properties.

The easiest, objective and exact way is the way of definition based on ability A.k. to recover ions of trivalent iron in ions of iron bivalent.

The quantity of the formed Fe2 ions + is equimolar to quantity A.k. in the analyzed sample (the minimum quantity A.k. in a sample — the 10th nmol) is also determined by staining reaction with ferricyanide potassium.

For what ascorbic acid is necessary?

Substance participates in processes of biotransformation of other vitamins, formation of collagen, and also education and an exchange of adrenaline and noradrenaline in marrow of adrenal glands, delivers hydrogen for formation of yaDNK, reduces need of an organism for vitamins of V-group, increases immunobiological body resistance, activity of leukocytes influences; improving assimilation of Fe, strengthens thereby synthesis of hemoglobin and maturing of erythrocytes, neutralizes the toxins emitted by pathogenic microflora, accelerates healing of wounds and postoperative seams and merging of changes.

Ascorbic acid in urine is an important indicator of health of an organism. The small amount of vitamin C in urine can demonstrate disturbances of work of internals or development of tumoral process. The increased concentration of ascorbic acid can signal about imbalance of a food allowance and about probability of existence of stones in kidneys.

Standard daily rate of excretion of vitamin C urine — 0,03 g. At diagnosis of such indicator it is possible to draw a conclusion that the person receives enough ascorbic acid, and its organism works optimum.

How many calories in ascorbic acid?

100 grams of a product contain 0,1 g of fats, 0,1 g of proteins and 95,78 g of carbohydrates. Such amount of carbohydrates allows to compensate more than a third (namely — 35% *) to daily need for them.

* average value of a nutrition value of products from different sources is given. Data can differ from actual depending on an origin of this or that product. Value is given for the diet meaning the use of 2 thousand kcal a day.

Caloric content of 100 grams of a product — 970 kJ or 231,73 kcal.

What ascorbic acid in cosmetology is useful to?

In cosmetology ascorbic acid is used as a part of the drugs which are slowing down aging, recovering protective functions and accelerating healing of means.

The easiest way of use of vitamin C for hair — to add powder (the crushed tablet) or solution to a one-time portion of shampoo or to a mask for hair. It is necessary to add an askorbinka to the looking after means just before their use.

Such simple procedures allow to recover structure of hair, to prevent their loss, and also to make hair soft and brilliant.

Ascorbic acid is most often applied to the person in powder. Before carrying out procedure powder (or the pounded tablets) is mixed with mineral water that dense gruel turned out. Means is put for 20 minutes on a face and after that washed away.

Also daily wipings by 1:1 solution of ascorbic acid divorced mineral water in a proportion are useful to the person. It is also possible to add solution/powder to masks of house preparation.

Than ascorbic acid is useful to athletes?

Vitamin C is a stimulator of anabolism of muscle bulk that does reasonable its use in bodybuilding. Besides, scientists managed to prove that due to suppression of process of peroxide oxidation and secretion of cortisol it also renders anticatabolic effect. Thus, reception of vitamin C before training will allow to protect muscles and will slow down an albuminolysis.

Upon completion of a rate of anabolic steroids ascorbic acid is accepted as the PKT component (postcourse therapy).

Ascorbic acid for a call of monthly

High doses of vitamin C interfere with intake of progesterone in a uterus therefore Ascorbic acid is quite often accepted at a delay of monthly.

However doctors do not advise to abuse this way. First, numerous use of an askorbinka can become the reason of problems with a gastrointestinal tract. Secondly, reception of tablets can complicate diagnosis of the reasons of failure of a menstrual cycle and further treatment.

Precautionary measures

It is necessary to avoid too fast intravenous administration of solution of Ascorbic acid. In case of need prolonged use of drug control of the ABP, function of kidneys, glucose level is necessary.

Ascorbic acids changes results of laboratory analyses.

Analogs

Additiva Vitamin C, Asvitol, Askovit, Vitamin C, S-injektopas Vitamin, Rostvit, Setebe 500, Tsevikap, Tselaskon Vitamin C, Tsitravit, Tardiferon (Gland sulfate + Ascorbic acid).

Zdravzona

  • Ascorbic acid-vial of 5% solution for injetion of 1 ml No. 10 ampulyseverny Chinese Farm. Corporation of Ltd.
  • Ascorbic acid-vial of 5% solution for injetion of 2 ml No. 10 ampulyseverny Chinese Farm. Corporation of Ltd.
  • Ascorbic acid No. 1 powder 2,5g bag/ozone/ozone of Ltd company
  • Ascorbic acid with mg glucose 100 +877mg No. 10 tab. Pharmstandard-Ufavita of joint stock company
  • Ascorbic acid 50 of mg No. 200 of a drazhefarmstandart-Ufavit of joint stock company
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Apteka24

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  • Ascorbic kislotadarnitsa (Ukraine, Kiev)

BIOSPHERE

  • Ascorbic acid with sugar No. 10 krutkasultan (Kazakhstan)
  • Ascorbic acid with glucose of 100 mg No. 10 of the tab. Borisovsky ZMP (Belarus)
  • Ascorbic acid of 50 mg No. 200 of a dragee in bankemarbiofarm joint stock company (Russia)
  • Ascorbic acid of 50 mg No. 200 of a drazhealtayvitamina (Russia)
  • Ascorbic acid with sugar of 25 mg No. 10 krutkamarbiofarm joint stock company (Russia)
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Section: Vitamins
PAY ATTENTION! Information on drugs on the website is help generalizing, collected from public sources and can form the basis for making decision on use of medicines it is not aware of treatment. Before medicine use Ascorbic acid surely consult with the attending physician.