York aspirin

Аспирин Йорк Drug photo

The description is actual on 01.04.2016

  • Latin name: Aspirin York
  • Active ingredient: Acetylsalicylic acid
  • Producer: York Pharmaceutical, Inc. (USA)


1 tablet of Aspirin York includes 325 mg of acetylsalicylic acid (aspirin).

Release form

The remedy York Aspirin is made in the form of tablets, on 100 pieces in a polymeric bottle.

Pharmacological action

Anti-aggregation, analgeziruyushchy, antiinflammatory, febrifugal.

Pharmacodynamics and pharmacokinetics

Medicine from the York Aspirin NPVS group, thanks to the active ingredient to acetylsalicylic acid, possesses analgeziruyushchy, antiinflammatory and febrifugal efficiency, typical for this substance, and also anti-aggregation activity (suppresses platelet aggregation). The central mechanism of effect of drug is connected with its ability to oppression of activity of TsOG, the main enzyme of metabolic transformations of the arachidonic acid representing the predecessor of prostaglandins playing the main role in forming of inflammatory processes, feverish states and painful feelings. Reduction in the center of thermal control of level of prostaglandins (the most part of E1) leads to expansion of skin vessels and increase of sweating that, in turn, becomes the reason of fall of temperature of a body. The anesthetizing efficiency is caused by both peripheral, and central influence of active ingredient of drug. Also also anti-aggregation influence of medicine (decrease in adhesion, aggregation of thrombocytes and suppression of a thrombogenesis) owing to oppression by it in A2 thromboxane synthesis thrombocytes is traced.

Reception of the tablets York Aspirin at the diagnosed unstable stenocardia reduces risk of developing of a myocardial infarction and the related lethality. Drug is quite effective at its appointment for the purpose of primary prevention of cardiovascular pathologies and secondary prevention of displays of a myocardial infarction. At oral daily administration of 6000 mg and more medicine slows down hepatic synthesis of a prothrombin, thereby increasing a prothrombin time. Increases fibrinolitic plasma activity and vitamin of K-dependent coagulant factors lowers contents (II, VII, IX, X). Increases a possibility of forming of hemorrhagic complications at operative measures, strengthens risk of developing of bleedings against use of anticoagulants. Stimulates excretion of uric acid in big dosages, breaking processes of its reabsorption in renal tubules. Because of blocking of TsOG-1 in mucous the gastrointestinal tract is noted to lead the suppression of gastroprotektorny prostaglandins able to ulcerations of mucous membranes and further bleedings.

At reception peroral (inside) the main part of active ingredient of the drug York Aspirin is quickly absorbed from a proximal site of a small bowel, and also in smaller quantities from a stomach. Presence at a food stomach substantially changes processes of absorption of acetylsalicylic acid.

Metabolic transformations of drug happen in a liver by means of hydrolysis to release of salicylic acid and to further conjugation with a glucuronide or glycine. Plasma concentration of salicylates is quite variable.

Salicylic acid approximately for 80% contacts plasma proteins. Salicylates with ease get into many liquids (including peritoneal, spinal and synovial) and body tissues, in small volumes are found in tissues of a brain and in residual quantities in bile, Calais and sweat. Quickly get through a placental barrier and are fixed in milk of the nursing mother (in small doses).

At babies salicylates are capable to force out bilirubin from its albuminous communication that can provoke forming of bilirubinovy encephalopathy.

In case of forming of acidosis the main part of salicylate will be transformed to not ionized acid possessing good penetration concerning various fabrics including a brain.

Penetration of drug into a joint cavity accelerates in the presence of puffiness and a hyperemia and is slowed down in a proliferative inflammatory phase.

Removal is carried out generally through the active secretion happening in tubules of kidneys. Drug is removed to 60% in not changed form, for the rest, in the form of products of its metabolism. Excretion of not changed salicylate is caused by urine pH, in a case alkalifying of which the ionizirovaniye of salicylates raises, their reabsorption goes down and significantly removal increases. Approximate T1/2 of acetylsalicylic acid is equal to 15 minutes. At reception of small doses of T1/2 of salicylate makes 2-3 hours and can increase with increase in a dosage of drug till 15-30 o'clock. At babies the elimination of salicylate occurs much more slowly, than at adults.

Indications to use

Aspirin tablets York are shown to reception at:

Also in gradually accruing dosages drug can be used in clinical allergology and immunology for the purpose of a long "aspirinovy" desensitization and production of steady tolerance to NPVS at patients with "an aspirinovy triad" and "aspirinovy asthma ".


Purpose of Aspirin York contraindicated at:

Side effects

Circulatory system:

  • anemia;
  • increase in duration of bleeding;
  • thrombocytopenia;
  • hemorrhagic syndrome.

Gastrointestinal tract system:

  • diarrhea;
  • disturbance of hepatic function;
  • nausea/vomiting;
  • bleedings from a gastrointestinal tract;
  • anorexia;
  • erosive cankers;
  • pains in epigastriums.

Urinary system:

  • disturbance of renal function;
  • nephrotic syndrome;
  • renal failure (acute).

Nervous system:

Allergic manifestations:

  • skin rash;
  • development of a bronchospasm;
  • Quincke's edema;
  • "aspirinovy triad" (combination of intolerance of aspirin, bronchial asthma, polypose of okolonosovy bosoms and nose).


  • strengthening of symptomatology of HSN;
  • syndrome to Reja it is (very rare).

York aspirin, application instruction

Aspirin tablets York are intended for peroral (in) reception, washing down 150-200 ml of water. The application instruction recommends to take aspirin of 325 mg to patients 12 pieces in 24 hours are more senior than 15 years on 1-2 tablets for once (325-650 mg), but no more, than. The interval between reception of tablets has to be not less than 4 hours.

At rhematoid polyarthritis, infectious and allergic myocarditis, rheumatism, as a rule, appoint York Aspirin in a daily dose 2-3 grams.

At prolonged treatment of a thrombogenesis, coronary atherosclerosis and strokes single daily dose of 50-100 mg of drug is shown.


The overdose symptomatology Aspirin moderately severe York is most often shown by dizziness, nausea/vomiting, a hearing disorder, confusion of consciousness, a sonitus and a headache.

In most cases these negative phenomena independently pass after the termination of reception of tablets.

Manifestations of heavy overdose can lead to the fever expressed to a hypoglycemia, hyperventilation, respiratory insufficiency, ketoacidosis, cardiogenic shock, a respiratory alkalosis, a coma and a metabolic acidosis.

Treatment of such states demands hospitalization of the patient, carrying out gastric lavage, purpose of sorbents, correction of acid-base equilibrium. Alkalinization of urine up to its indicator is also shown rn equal 7,5-8 (consider that alkalinization of urine is reached fully in case of fixing of plasma level of salicylic acid more than 500 mg/l for adult patients and more than 300 mg/l for teenagers), completion of the lost liquid, carrying out a hemodialysis and further symptomatic therapy.


The combined use of antiacid means on the basis of aluminum and/or magnesium reduces and slows down absorption of active ingredient of drug.

At parallel administration of drugs from group of antagonists of calcium, and also the means limiting supply of calcium or strengthening its excretion from an organism the risk of developing of bleedings increases.

Simultaneous use of Aspirin York with Insulin, indirect anticoagulants, Heparin, hypoglycemic drugs derivative sulfonilmochevina, the Methotrexate, Valproic acid and Phenytoinum strengthens their main action.

Joint reception with glucocorticoids increases possibility of ulcerogenic effects and forming of bleedings from a gastrointestinal tract.

One-time use with diuretics (Furosemide, Spironolactonum) reduces their efficiency.

The combination with other drugs from NPVS of group raises an opportunity emergence of negative side effects.

Aspirin can reduce plasma concentration of Piroxicam and Indometacin.

Sochetayemy appointment with drugs of gold can become the reason of injury of a liver.

Parallel reception of uricosuric means (including Probenetsid, Benzbromaron, Sulfinpyrazonum) lowers their efficiency.

Joint therapy alendronaty sodium can provoke forming of a heavy esophagitis.

At the accompanying use of Griseofulvin observed aspirin absorption disturbance.

At long treatment aspirin in a daily dose of 325 mg and parallel administration of drug, the biloba Ginkgo including extract, noted an episode of spontaneous hemorrhage in a cover of an eye (iris). Assume that this phenomenon was caused by the inhibiting additive impact on platelet aggregation.

The combined reception of Dipiridamolum can increase plasma Cmax and AUC salicylate.

Simultaneous therapy by acetylsalicylic acid with barbiturates, Digoxin or salts of lithium increases plasma keeping of the last.

At parallel reception of inhibitors of a karboangidraza and high doses of salicylates forming of intoxication salicylates is possible.

Caffeine is capable to increase the absorption speed, bioavailability and plasma level of acetylsalicylic acid.

York aspirin in daily dosages less than 300 mg slightly influences efficiency of Enalapril and Captopril. Significant decrease in efficiency of these drugs is observed at reception of high doses of acetylsalicylic acid.

Combined use with Metoprolol can lead to increase of plasma content of salicylate.

Long reception of high doses of aspirin and simultaneous carrying out treatment with use of pentazocine strengthens risk of development of serious by-effects from kidneys.

Etanolsoderzhashchy drugs can increase negative effect of aspirin concerning bodies of a gastrointestinal tract.

Parallel use of phenylbutazone lowers the uricosuria caused by reception of acetylsalicylic acid.

Terms of sale

Aspirin purchase York does not demand existence of the recipe.

Storage conditions

The maximum temperature threshold of storage of drug is equal to 30 °C.

Period of validity

From the moment of production of tablets – 3 years.

Special instructions

Careful purpose of Aspirin York patients with bronchial asthma, pathologies of livers/kidneys, bleedings and/or erosive cankers of a gastrointestinal tract in the anamnesis demand, dekompensirovanny HSN, and also the patients who are on anticoagulative therapy or with the inborn raised bleeding.

Reception even of small dosages of acetylsalicylic acid reduces removal from an organism of uric acid that at the patients predisposed to it can lead to a bad attack of gout.

In case of reception of high doses of Aspirin York or long treatment with its use, it is necessary to conduct regular examinations of the patient and to control the serumal level of hemoglobin.

It is necessary to limit reception of high daily doses (5-8 grams) of acetylsalicylic acid as an antiinflammatory remedy as such dosages of aspirin with a high share of probability can lead to development of negative side effects (expression, bleeding) from bodies of a gastrointestinal tract.

During long treatment by Aspirin York needs to be directed systematically the patient to delivery of the general blood test and a calla (for definition of the possible occult blood).

Before carrying out planned surgeries recommend for 5-7 days to them to cancel Aspirin reception York, for the purpose of decrease in bleeding at an operative measure. Also in the post-operational period it is better to avoid reception of salicylates for 7-10 days.

Duration of reception of the tablets York Aspirin, without preliminary approval of the doctor, has to be limited 7 days for analgeziruyushchy effect and 3 days for febrifugal action.


Section: Anesthetics Anti-cold
in more detail

Education: Graduated from the Vinnytsia national medical university of N. I. Pirogov, pharmaceutical faculty, the higher pharmaceutical education – the specialty "Pharmacist".

Experience: Work in Koneks and Bios-Media pharmacy chains as "Druggist". Work as "Pharmacist" in Avicenna pharmacy chain of the city of Vinnytsia.

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