AZZ Long

АЦЦ Лонг Drug photo

The description is actual on 19.12.2015

  • Latin name: ACC Long
  • ATH code: R05CB01
  • Active ingredient: Acetylcysteinum (Acetylcysteine)
  • Producer: Hexal AG (Germany)

Structure

Longum is a part of means of AZZ active ingredient Acetylcysteinum (600 mg), and also some additional components: Natrii hydrocarbonas, citric acid, Mannitolum, sodium carbonate, ascorbic acid, cyclomate of sodium, citrate sodium dihydrate, saccharinate sodium dihydrate, fragrance.

Release form

AZZ Longum is made in tablets sparkling. Tablet AZZ round, white, on the one hand tablets – risk, with another – a smooth surface. Tablets have aroma of blackberry.

After the tablet is dissolved in water, solution without color with aroma of blackberry turns out. Tablets are packed into polypropylene tubas on 6, 10 or 20 pieces.

Pharmacological action

Means has mucolytic effect. As in structure of a molecule of Acetylcysteinum there are sulphhydryl groups, it provides a rupture of disulfide bridges of acid mucopolysaccharides of a phlegm. As a result viscosity of slime decreases.

AZZ Longum is also active if at the patient the purulent phlegm is allocated.

Provided that drug is used for the purpose of prevention, expressiveness and frequency of aggravations at people who are ill a mucoviscidosis and chronic bronchitis decreases.

Pharmacokinetics and pharmacodynamics

Getting to an organism, it is soaked up quickly. The metabolism occurs in a liver, at the same time the active metabolite — cysteine, also cystine, diacetylcysteinum, the mixed disulfides is formed pharmacological.

At oral administration bioavailability level — 10% (as the expressed effect of the first passing takes place). The largest level of concentration in blood is defined 1–3 hours later. Contacts proteins of plasma for 50%. It is brought out of an organism through kidneys. Time of semi-removal is equal to about 1 hour if functions of a liver are broken, then the elimination half-life is equal to 8 hours. Through a placental barrier gets. There are no data on penetration through GEB.

Indications to use

AZZ Longum is applied in the following cases:

  • at diseases of a respiratory organs which are accompanied by formation of a viscous phlegm that difficult separates (bronchitis acute and chronic, laryngotracheitis, obstructive bronchitis, bronchiectasias, pneumonia, a mucoviscidosis, bronchiolites, asthma bronchial);
  • sinusitis acute and chronic;
  • average otitis.

Contraindications

It is contraindicated to ATsTs 600 to apply in the following cases:

  • at pregnancy and chest feeding;
  • at the age of the patient till 14 flyings;
  • at high sensitivity to medicine components.

Carefully means is applied at stomach ulcer and a duodenum in the period of an aggravation, at pulmonary bleeding, a pneumorrhagia, a gullet varicosity, asthma bronchial, diseases of adrenal glands, and also at a liver and renal failure.

Side effects

Such side effects in the course of treatment can be shown:

  • nervous system: in rare instances — a sonitus, headaches;
  • system of digestion: stomatitis, vomiting, diarrhea, nausea, heartburn;
  • heart and vessels: tachycardia, lowering of arterial pressure;
  • allergy: a bronchospasm (in isolated cases – generally at patients with hyperreactivity of bronchial tubes), urticaria, rash on skin, an itch;
  • other manifestations: bleeding — in isolated cases.

Sparkling tablets AZZ Longum, application instruction (Way and dosage)

Drug of 600 mg is appointed, as a rule, to patients after 14 flyings. The application instruction of AZZ Longum 600 provides that the patient has to accept on 1 tablet sparkling in days, such dose corresponds to 600 mg of Acetylcysteinum.

The tablet is dissolved in 1 glass of water, it is necessary to accept right after the tablet is dissolved. Reception of ready solution for two hours in exceptional cases is allowed.

If it is about catarrhal diseases, then treatment continues for 5-7 days. If it is necessary to carry out treatment of other diseases having longer current, duration of therapy is determined by the doctor. To people with chronic bronchitis more prolonged treatment is appointed to provide prevention of infections.

Administration of drug is carried out after food.

At treatment drug AZZ of a tablet recommends reception of additional amount of liquid to provide strengthening of mucolytic action.

Overdose

At overdose the following manifestations can be shown: abdominal pain, vomiting, diarrhea, nausea. Heavy symptoms at overdose were not observed.

In such cases carry out a symptomatic treatment.

Interaction

In case of a concomitant use of Acetylcysteinum and antitussives owing to suppression of a tussive reflex the probability of stagnation of slime increases. Therefore it is necessary to combine such drugs carefully.

If treatment by Acetylcysteinum and Nitroglycerine at the same time practices, vasodilating effect of nitroglycerine can amplify.

Acetylcysteinum is not combined pharmaceutical with a number of antibiotics (cephalosporins, penicillin, Erythromycin, Amphotericinum In, Tetracycline) and with proteolytic enzymes.

Under the influence of Acetylcysteinum the level of absorption of cephalosporins, Tetracycline, penicillin decreases. In this regard it is necessary to observe an interval between reception of these means not less than 2 hours.

If Acetylcysteinum contacts to rubber, metals, there is a formation of sulfides to a characteristic smell.

Terms of sale

AZZ Longum can be got without recipe.

Storage conditions

Temperature of storage should not be more than 30 degrees, it is necessary to store it in the dry, dark place, to protect from access for children. After the tablet was taken, it is necessary to close a tuba densely.

Period of validity

3 years store drug.

Special instructions

Important with care to apply AZZ Longum to treatment of patients with bronchial asthma and obstructive bronchitis. At the same time it is necessary to provide systematic control of bronchial passability.

If in the course of therapy side effects are shown, it is necessary to stop reception and to address the specialist.

It is recommended to dissolve tablets in ware from glass to avoid contact with rubber, metal, easily oxidized materials.

Patients with a diabetes mellitus have to consider what in one tablet corresponds to 0.01 HE.

Analogs

Analogs of medicine AZZ Longum are means of AZZ, N-ATs-ratiofarm, Acetylcysteinum, N-Acetylcysteinum, Atsestin, Fluimucil, Mucomystum, Mukobene, Mukoneks, etc. The specialist has to select the most optimum drug individually.

Zdravzona

  • AZZ longum of 600 mg No. 10 of a tablet shipuchiyehexal Pharma Gmbh
  • AZZ longum of 600 mg No. 20 of a tablet shipuchiyehexal Pharma Gmbh
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Apteka24

  • Azz longsalutas Pharma (Germany)
Section: For cough
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Education: "Pharmacy" graduated from the Rovno state basic medical college majoring in. Graduated from the Vinnytsia state medical university of M. I. Pirogov and internship on its base.

Experience: From 2003 to 2013 – worked at positions of the pharmacist and manager of a pharmaceutical booth. It is awarded by diplomas and distinctions for long-term and honest work. Articles on medical subject were published in local editions (newspaper) and on various Internet portals.

PAY ATTENTION! Information on drugs on the website is help generalizing, collected from public sources and can form the basis for making decision on use of medicines it is not aware of treatment. Before use of AZZ medicine Longum surely consult with the attending physician.