ATSTS

АЦЦ Drug photo

The description is actual on 19.01.2016

  • Latin name: ACC
  • ATH code: R05CB01
  • Active ingredient: Acetylcysteinum (Acetylcysteine)
  • Producer: Salutas Pharma, Lindopharm GmbH, Alphahoney Farbil Artsnaymittel Gmbh, Pharma Wernigerode GmbH (Germany)

Structure

Active component Acetylcysteinum is a part of means of AZZ in tablets, and also medicine contains additional components: anhydrous citric acid, sodium carbonate anhydrous, hydrosodium carbonate, Mannitolum, anhydrous lactose, sodium citrate, ascorbic acid, sodium saccharinate, fragrance.

AZZ powder contains in structure active component Acetylcysteinum, and also additional components: sucrose, ascorbic acid, sodium saccharinate, fragrance.

Release form

Drug ATsTs 100 (AZZ children's) and ATsTs 200 is made (for adult patients).

Medicine is issued in the form of sparkling tablets, and also in the form of granules which are used for solution use. Tablets are white, on the one hand risk, have aroma of blackberry. The slight smell of sulfur can be noted. Tablets are applied to solution preparation – transparent, with aroma of blackberry.

Granules are white, homogeneous, have aroma of honey and a lemon or orange. Granulate contains in packages from a foil, in a cardboard pack on 20 packages.

Pharmacological action

Wikipedia demonstrates that substance Acetylcysteinum is derivative cysteine amino acids. Has mucolytic effect, under its influence process of an otkhozhdeniye of a phlegm as substance influences directly rheological properties of a phlegm is facilitated. Its influence is connected with ability to terminate disulfide bridges of mukopolisakharidny chains owing to what the depolymerization of mukoproteid of a phlegm is noted. As a result viscosity of a phlegm decreases.

Drug is also active if the patient has a purulent phlegm.

Also the summary contains information that AZZ provides the antioxidant action connected with ability of reactive sulphhydryl groups to neutralize oxidizing radicals, contacting them. So protection of cells against oxidation which often happens at inflammatory reactions increases.

Also Acetylcysteinum activates the glutathione which is important part of anti-oxidizing system and a chemical detoxication of an organism.

If AZZ is applied for the purpose of prevention, weight and frequency of aggravations at the people suffering from a mucoviscidosis and chronic bronchitis considerably decreases.

Pharmacokinetics and pharmacodynamics

High level of absorption of drug is noted. The metabolism occurs in a liver, at the same time the active metabolite — cysteine, also cystine, diacetylcysteinum, the mixed disulfides is formed.

At reception orally the level of bioavailability is equal to 10% (as the expressed effect of the first passing through a liver is noted). The maximum concentration in plasma is noted 1-3 hours later. Contacts blood proteins for 50%.

It is removed with urine in the form of inactive metabolites. The elimination half-life is equal to 1 hour if at the patient functions of a liver are broken, then it can be extended till 8 o'clock.

Through a placenta gets, given about penetration through GEB is not present.

Indications to use

The following indications to use of this drug are noted:

  • diseases of a respiratory organs at which the viscous phlegm which difficult separates is formed;
  • bronchitis acute and chronic;
  • tracheitis, obstructive bronchitis, laryngotracheitis;
  • bronchoectatic disease;
  • pneumonia;
  • bronchial asthma;
  • mucoviscidosis;
  • lung abscess;
  • chronic obstructive pulmonary disease;
  • sinusitis acute and chronic;
  • average otitis.

Contraindications

Such contraindications for all forms of drug are noted:

Carefully appoint drug to patients with stomach ulcer or a duodenum in the anamnesis, at intolerance of a histamine (it is impossible to apply throughout a long time), at bronchial asthma, a gullet varicosity, bronchitis obstructive, diseases of adrenal glands, arterial hypertension, a liver and/or renal failure.

Additional contraindications for sparkling tablets of 200 mg:

  • lack of lactase, lactose intolerance;
  • malabsorption is glyukozo-galaktozny;
  • age of the patient till 2 flyings;

Additional contraindications for granules:

  • intolerance of fructose;
  • lack of invertase/isomaltase;
  • insufficiency is glyukozo-galaktozny;
  • age of the patient till 6 flyings.

Side effects

In the course of treatment such side effects can be noted:

Application instruction of AZZ (Way and dosage)

Drug in sparkling tablets or granules in bags needs to be accepted orally and at the same time to adhere to that dosage which is specified in the instruction. It is necessary to drink after meal.

Powder AZZ, application instruction

The instruction on powder AZZ of 100 mg provides that means needs to be dissolved in half of glass of water then at once to drink. Children from two to six years receive a day 200-300 mg of means in 2-3 receptions. AZZ children's patients aged from 6 till 14 flyings receive a day 300-400 mg in 2-3 receptions. Patients after 14 flyings receive 400-600 mg of means a day in 2-3 receptions. People who are ill a mucoviscidosis and whose weight makes more than 30 kg can receive up to 800 mg of medicine in days. At the same time all contraindications have to be considered.

If it is about an acute illness without complications, then the patient can receive drug without medical supervision not longer than five days. At chronic diseases the doctor has to determine duration of therapy.

The application instruction of AZZ for children

Tablets or powder of 200 mg for children are used seldom. This drug is appointed to children of 6 flyings. Powder AZZ of 100 mg is applied to children of 2 flyings, at the same time the doctor has to appoint a dosage.

Sparkling tablets dissolve in 1 station of water, also for this purpose it is possible to use tea or juice.

Before accepting powder of 200 mg, it is necessary to consider that additional plentiful drink allows to strengthen mucolytic effect of the medicine. The route of administration of powder of 200 mg depends on recommendations of the doctor.

AZZ for cough at cold can be accepted within 5-7 days. If for cough drug does not help throughout this period, it is necessary to see a doctor who will make recommendations how to accept AZZ in bags.

It is important to consider how to drink powder of 200 mg at a mucoviscidosis and chronic bronchitis: in that case treatment is carried out longer.

Overdose

If Acetylcysteinum was accepted by the patient in a dose which exceeds at reception 500 mg a day, at it overdose signs why it is necessary to adhere to strictly appointed scheme of treatment can be shown. In that case at the patient vomiting, diarrhea, heartburn, abdominal pains can develop. At overdose symptomatic therapy is carried out.

Interaction

In case of a concomitant use of Acetylcysteinum and antitussives at dry cough the tussive reflex can be suppressed and, as a result, stagnation of a phlegm is noted.

In case of simultaneous treatment by antibiotics (tetracyclines, penicillin, cephalosporins) their interaction with thiol group of Acetylcysteinum can be noted. As a result, antibacterial activity of such drugs decreases. It is important to avoid such effect for what it is necessary to adhere to an interval not less than 2 hours between receptions of antibiotics and Acetylcysteinum.

At simultaneous use with vazodilatiruyushchy drugs and Nitroglycerine vasodilating influence of the last can amplify.

Terms of sale

Means is implemented in drugstores according to the recipe.

Storage conditions

It is necessary to store granules and tablets at t not above 25 °C, to protect from children.

Period of validity

The storage period – 3 years.

Special instructions

When using Acetylcysteinum cases of development of heavy allergic manifestations were very seldom fixed. If after use of medicine for the patient changes on skin or on mucous appear, it is necessary to see a doctor at once. Drug intake is stopped at the same time.

Before beginning treatment, it is necessary to know how to prepare solution in what water to dissolve granules and tablets. How to part 200 mg of AZZ, depends on the appointed scheme of treatment. As a rule, granules dissolve, gradually stirring them in one station of hot water. It is necessary to drink solution hot too. It is recommended to part medicine in glasswares.

It is necessary to consider not only at what cough to take medicine, but also respect for care at drug intake by patients with obstructive bronchitis and bronchial asthma. It is important to control bronchial passability constantly.

It is recommended to accept means till eighteen o'clock, before going to bed directly medicine is not recommended to be drunk.

Patients with a diabetes mellitus need to consider that as a part of HP sucrose contains.

At treatment by drug the patient can steer vehicles or work with dangerous mechanisms.

Analogs of AZZ

Analogs of this drug are means Atsestin, Acetylcysteinum solution for inhalations, Acetylcysteinum, Fluimucil, AZZ of Injekt, etc. The price of drugs depends on the producer, packaging. The specialist will help to choose the most optimum means.

Zdravzona

  • Azz 100mg/5ml granules for preparation of syrup 60 of flakonhexal Pharma Gmbh
  • AZZ longum of 600 mg No. 10 of a tablet shipuchiyehexal Pharma Gmbh
  • Azz of 100 mg No. 20 of a tablet sparkling for deteyhexal Pharma Gmbh
  • Azz of 200 mg No. 20 of a tablet shipuchiyehexal Pharma Gmbh
  • Azz of 100 mg of a granule for Preeg. solution for intake of 3 g No. 20 paketikihexal Pharma Gmbh

Drugstore of IFC

  • AZZ granulate for prigot. solution 200 of mg No. 20 (orange), Hexal Aggermaniya
  • ATsTs 100 tbl thorn. 100 mg No. 20, Hexal Aggermaniya
  • AZZ-longum tbl thorn. 600 mg No. 10, Hexal Aggermaniya
  • ATsTs 200 tbl thorn. 200 mg No. 20, Hexal Aggermaniya
  • AZZ syrup 20mgml fl 100 ml, Pharma Wernigerodegermaniya
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Apteka24

  • Azzsalutas Pharma (Germany)
  • Azz longsalutas Pharma (Germany)
  • AZZ solution shouted. 20mg/ml 100mlsandoz
  • Azz20
  • Azz6

Paniapteka

  • AZZ 100 time. for the ave. solution 100 of mg No. 20sandoz
  • AZZ 100 time. for the ave. solution 100 of mg No. 20sandoz
  • AZZ 100 time. for the ave. solution 100 of mg No. 20sandoz
  • AZZ 100 time. for the ave. solution 100 of mg No. 20sandoz
  • AZZ 100 time. for the ave. solution 100 of mg No. 20sandoz

BIOSPHERE

  • АЦЦ® 200 mg No. 50 por.d / solution for intake a pack ice. Salyutas of Farm Gmbh (Germany)
  • АЦЦ® the junior of 60 g por.d / solution for reception vnutryalfamed Farbil Artsneymittel Gmbh (Germany)
  • АЦЦ® 200 mg No. 20 por.d / solution for intake a pack ice. (sachet) Salyutas of Farm Gmbh (Germany)
  • АЦЦ® 600 mg No. 10 of the tab. thorn. GEKSAL AG (Germany)
  • АЦЦ® 200 mg No. 20 of the tab. thorn. Salyutas of Farm Gmbh (Germany)
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Section: For cough
in more detail

Education: "Pharmacy" graduated from the Rovno state basic medical college majoring in. Graduated from the Vinnytsia state medical university of M. I. Pirogov and internship on its base.

Experience: From 2003 to 2013 – worked at positions of the pharmacist and manager of a pharmaceutical booth. It is awarded by diplomas and distinctions for long-term and honest work. Articles on medical subject were published in local editions (newspaper) and on various Internet portals.

PAY ATTENTION! Information on drugs on the website is help generalizing, collected from public sources and can form the basis for making decision on use of medicines it is not aware of treatment. Before use of AZZ medicine surely consult with the attending physician.