Drug photo

The description is actual on 15.07.2016

  • Latin name: Asomex
  • ATH code: C08CA01
  • Active ingredient: Amlodipin (Amlodipine)
  • Producer: Emkyor Farmasyyutikals of Ltd. for "Aktavis of groups of the joint-stock company" (India/Iceland)


Amlodipina besilat, microcrystallic cellulose, silicon dioxide colloid, lactose, iron oxide, sodium of a kroskarmelloz, magnesium stearate.

Release form

Tablets of Azomeks of 2,5 mg and Azomeks of 5 mg in the blister on 10 pieces in cardboard packaging No. 30.

Pharmacological action

Anti-hypertensive, anti-anginal.

Pharmacodynamics and pharmacokinetics


The left-handed isomer of an amlodipin (S) relating to derivatives of dihydropyridine and consisting of two stereomer is a part of drug, but only left-handed amlodipin possesses pharmacological activity. The mechanism of action is caused by ability of drug to block calcium channels therefore process of penetration into cells of a cardiac muscle and vessels of calcium ions is stopped. As a result of it, in cells of unstriated muscles the tone of a wall of vessels decreases that AHA (anti-hypertensive action) leads to decrease.

Drug also possesses the expressed anti-anginal action which is caused by influence of an amlodipin on cardiovascular system (expands peripheral vessels, thereby reduces peripheric vascular resistance). As a result of decrease in peripheric resistance of vessels the afterload decreases and there is a decrease in load of a cardiac muscle and its oxygen requirements. Exerting impact on unstriated muscles of walls of vessels, drug reduces a spazmirovaniye of vessels of heart and normalizes a coronary blood stream. Azomeks does not render the expressed influence on an exchange of fats and carbohydrates therefore it is possible to appoint him the patient with bronchial asthma, gout and a diabetes mellitus.


Azomeks it is well absorbed in a gastrointestinal tract, meal does not exert impact on drug absorption level. Bioavailability of drug — about 70-80%. Therapeutic concentration of drug is reached in 10-12 hours, does not cause sharp falling of arterial pressure because of the slow beginning of action of Azomeks. Resistant concentration in blood comes in 7-8 days. It Biotransformirutsya with formation of inactive metabolites. The elimination half-life — is removed 35-50 hours with urine.

Indications to use

In therapy of arterial hypertension and coronary heart disease.


High sensitivity to drug, arterial hypotension, the period of pregnancy and a lactation, age till 18 flyings.

Side effects

System and local allergic reactions, drowsiness, headache, depression, sleeplessness, nausea, meteorism, diarrhea, dryness in a mouth, vomiting, tachycardia, dizziness, hypotension, increase in frequency of an urination, rash, a dieback, an erythema, an itch, an adynamy, mialgiya, spasms, arthralgias.

Azomeks, application instruction (Way and dosage)

Pill of Azomeks is taken regardless of meal, swallowing it entirely, washing down with water. In therapy of arterial hypertension and an ischemic heart disease drug is appointed in an initial dosage of 2,5-5 mg which in case of need it is possible to increase to 10 mg of 1 times a day. All dose is accepted at one time.


Lowering of the ABP, tachycardia/bradycardia.


Drug is safe at reception together with alpha-adrenoblockers, thiazide diuretics, b-adrenoblockers, nitrates of long action, APF inhibitors, nitroglycerine, with NPVS and peroral hypoglycemic drugs. Azomeks does not influence significantly efficiency of cyclosporine. Azomeks's bioavailability can increase at reception of grapefruit juice that can lead to strengthening of hypotensive effect of drug.

Terms of sale

According to the recipe.

Storage conditions

In the dry place at a temperature not above 25 °C.

Period of validity

24 months.

Azomeks's analogs

Agen, Norvask, Amlosandoz, Amlong, Tenoks, Amlodipin-Zdorovye, Amlo and others.

About Azomeks

About drug among most of patients positive. Antagonists of calcium — highly effective drugs which are used in clinical practice more than 30 years. This drug has advantages as contains S-isomer of an amlodipin which possesses bigger pharmacological activity therefore its dose can be reduced and the risk of side effects decreases.

The active S-form differs in the bigger duration of semi-removal, renders the prolonged hypotensive effect and a single dose happens enough for control of the ABP.  Patients have no need for dose adjustment with renal failures. Drug can be accepted it is long and to it tolerance does not develop. Judging by responses, some patients took a pill of Azomeks as means of monotherapy, and some in a combination with other anti-anginal means (β-adrenoblockers, nitrates). All note its efficiency. Azomeks's use causes a minimum of side effects.

In pharmacy chain it is possible to buy the combined drug Azomeks of N whose action is strengthened by hypothiazid (diuretic). Azomeks Lo-Azomeks analog contains S-amlodipin + lozartan potassium and is more effective drug.


  • Azomeks No. 30emkyor tablets 2.5mg Farmasyyutikals/Aktavis (India)
  • Azomeks tablets 5 of mg No. 30emkyor Farmasyyutikals/Aktavis (India)
  • Azomeks N of a tablet 2.5mg/12.5mg No. 30emkyor Farmasyyutikals/Aktavis (India)
Section: Cardiovascular
in more detail

Education: Graduated from Sverdlovsk medical school (1968 - 1971) as "Paramedic". Graduated from the Donetsk medical institute (1975 - 1981) as "An epidemiologist, a hygienist". Passed postgraduate study in the Central scientific research institute of epidemiology Moscow (1986 - 1989). An academic degree – the candidate of medical sciences (degree is awarded in 1989, protection – the Central scientific research institute of epidemiology Moscow). Numerous advanced training courses are studied in epidemiology and infectious diseases.

Experience: Work as the manager of department of disinfection and sterilization of 1981 - 1992. Work as the manager of department of especially dangerous infections of 1992 - 2010. Teaching activity at Medical institute 2010 - 2013.

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