Betagistin

Drug photo

The description is actual on 31.12.2014

  • Latin name: Betahistinum
  • ATH code: N07CA01
  • Active ingredient: Betagistin (Betahistine)
  • Producer: CJSC Pharmaceutical Enterprise OBOLENSKOYE (Russia)

Structure

The main active ingredient — a betagistina dihydrochloride.

Auxiliary components:

  • sodium of a kroskarmelloz;
  • sodium lauryl sulfate;
  • cellulose microcrystallic;
  • citric acid;
  • magnesium stearate.

Release form

  • Tablets ploskotsilindrichesky a round form of white color with the put marking with the indication of a dose of active agent (8 mg).
  • Tablets oblong biconvex with the rounded edges with the marking applied on a surface designating a dose of content of active agent – 16 and 24 mg, respectively.

Pharmacological action

Betagistin is the analog of a histamine created by a synthetic method. Generally active agent of drug is capable to involve histamine N-1i N-3 receptors (weak and strong antagonists) of TsNS. In this case receptors of an inner ear and vestibular nuclei mean.

Betagistina dihydrochloride influences a blood stream, stimulating microcirculation and permeability of capillaries of an inner ear. Besides, active ingredient of this drug stabilizes endolymph pressure in a snail and a labyrinth.

Thanks to the fact that Betagistin in fact is N-3 inhibitor of receptors of kernels of a vestibular mechanism this drug renders pronounced effect on TsNS, stabilizing neyronalny transmission in neurons of a vestibular nucleus.

Betagistin at the correct reception is capable to neutralize symptoms of vestibular dizziness very quickly.  The period of influence of active agent of this drug makes of several minutes till 24 o'clock. Regular reception of Betagistin under supervision of the doctor will reduce the frequency and efficiency of dizziness, will reduce at patients noise and a ring in ears, and also will recover hearing in case of its deterioration. Drug does not make sedative impact and does not cause various lacks of coordination. Does not influence hemadens.

Pharmacodynamics and Pharmacokinetics

Betagistin is quickly and completely soaked up after oral administration of drug in tablets. Peak concentration in plasma of active agent of drug it is reached approximately in one hour after peroral introduction on an empty stomach. Afterwards Betagistin contacts proteins of a blood plasma of the person, however It should be noted very low level of communication – less than 5%.

In a blood plasma the maximum concentration of active ingredient is reached approximately in 60 minutes. It is brought out of an organism as a result of a metabolism by metabolizing to inactive metabolites — 2-pyridylacetic acid (the main metabolite) and a demetilbetagistina.

Almost full removal of substances of drug happens within a day generally through kidneys (about 90%), the remained 10% are brought through intestines and a liver.

Indications to Betagistin's use

Very often on the Internet forums users ask a question: "From what Betagistin?".

Indications to Betagistin's use the following: treatment of a syndrome of Menyer, and also symptoms which can include dizziness, a sonitus, a partial hearing loss, nausea, a lack of coordination.

Reference: Menyer's syndrome is shown in the form of the vestibular and acoustical frustration which were earlier not observed at the person. Can develop in the form of an acute stroke. Possesses a high probability of the subsequent recurrence.

Contraindications

Betagistin is contraindicated to patients with a pheochromocytoma. As this medicine is synthetic analog of a histamine, its reception can cause release of catecholamines that leads to heavy hypertensia.

Besides Betagistin's reception is contraindicated if at the patient hypersensitivity to active agent or to any of the excipients which are a part of this drug is observed.

Side effects

Along with obvious useful effects, Betagistin's reception can provoke manifestation of side effects.

Attention: not each patient accepting this drug will feel discomfort and to observe manifestation at least of one of the listed below side effects.

Specialists warn that manifestation of side effects at reception of any medicine is not always treated in a negative key. As a rule, in most cases any reaction can mean adaptation of an organism to new drug therefore before making decision on refusal of the use of medicine it is necessary to consult with the doctor.

The cumulative side effects from Betagistin's reception are observed at one of ten patients who take this medicine. The list of the most often found side effects includes such symptoms as:

  • general feeling sick;
  • gastric disturbance (arises at administration of drug to food that is strictly contraindicated);
  • headache (in this case it is worth accepting an anesthetic, according to the preliminary recommendation of the specialist);
  • abdominal distention or discomfort;
  • allergic skin reactions, such as zud and rash (at manifestation of such reactions it is necessary to use antihistamine or to spread problem sites of skin with the moisturizing cream).

If the specified recommendations will not help to eliminate side effects, the patient needs to see without fail a doctor before to accept the next dose of Betagistin.

Application instruction of Betagistin

Medicine Betagistin needs to be taken strictly according to the instruction.

Dosage for adults:

Dizziness pill needs to be taken with food or after food in a dosage of 8 or 16 mg three times a day at the initial stage of treatment by this drug.

Maintenance doses of medicine, as a rule, vary in the range of 24 — 48 mg a day to the discretion of the attending physician. The daily dose should not exceed 48 mg. The dosage can be corrected taking into account specific features of health of patients. Sometimes improvement can be observed only after several weeks of treatment.

Treatment of patients with liver, renal and heart failure:

For patients with a liver failure treatment by Betagistin has to be appointed after carrying out careful research. Also treatment of patients with renal and heart failure is appointed.

Treatment of patients of advanced age:

At advanced age Betagistin it is necessary to use with care as in this group of the population there is a high probability of manifestation of negative reactions from an organism on acting and the excipients which are a part of medicine.

Betagistin, the instruction of use for children and teenagers:

Tablets Betagistin are not recommended for use for children and teenagers at the age of less than 18 years due to the lack of data on safety and efficiency of drug.

Overdose

General information about cases of overdose by Betagistin was not given. It is known that some patients tested easy and moderate symptoms in the form of a headache, nausea, drowsiness and pain in a stomach at administration of drug in a dose to 640 mg.

Other symptoms of overdose: vomiting, dyspepsia, ataxy and spasms.

More serious complications: spasms, pulmonary or cardiovascular complications were observed in cases of deliberate overdose of medicine, especially in combination with other medicamentous drugs. The specific antidote is absent therefore in case of overdose this medicine recommends a gastric lavage within one hour after reception.

Interaction with other medicines

There are no proved cases of dangerous medicinal interactions now.

Terms of sale

Drug is released in drugstores only according to the recipe of the doctor with the corresponding press.

Storage conditions

This medicine needs to be stored at the room temperature which is not exceeding 25C Celsius far from moisture and heat. Tablets are recommended to be held in the tight container.

Period of validity

Period of validity 2 years. On expiry date to take a pill strictly contraindicated in order to avoid negative manifestations from bodies and systems of an organism.

Betagistin's analogs

Betagistin's analogs similar in structure and effective impact on an organism:

  • Alfaserk – antihistaminic drug in the form of tablets or drops;
  • Asniton — drug in the form of tablets;
  • Beta beliefs – drug in the form of tablets.
  • Betagistin-Nanolek;
  • Betagistin-SZ;
  • Betagistina hydrochloride;
  • Betagistina dihydrochloride;
  • Betaserk – drug in the form of tablets;
  • Vestibo – drug in drug in the form of tablets;
  • Vestikap – drug in the form of tablets;
  • Mikrozer;
  • Tagista — drug in the form of tablets.

About Betagistin

As in a case with all medicines, About Betagistin have not always positive character. At specialized forums it is very often possible to meet About drug, speaking about not always stable effect. In this connection most of the people suffering from chronic disturbances of activity of cardiovascular system are forced to resort to reception of these tablets regularly. But also it does not guarantee disposal of headaches and dizziness.

Nevertheless, is much and positive responses. For example, several women wrote that during approach of a climax they began to feel the wild headaches and attacks of dizziness which are not allowing them even to incline slightly the head down as at these moments lost coordination completely. After Betagistin's appointment the specified symptoms at them disappeared completely, clarity of mind and ease in all body appeared.

Both positive, and negative responses say that this medicine demands very thin use — at one disturbances it can recover completely health, and at others, on the contrary, will not render the expected effect, and will only reduce manifestation of symptomatology.

Zdravzona

  • Betagistin of 24 mg No. 20 tabletkiverteks closed joint stock company
  • Betagistin of 8 mg No. 30 tablet/canon / Kanonfarma production closed joint stock company
  • Betagistin of 16 mg No. 30 of a tablet / northern star / Northern star of closed joint stock company
  • Betagistin of 24 mg No. 60 tabletkiverteks closed joint stock company
  • Betagistin of 24 mg No. 60 tablet/canon / Kanonfarma production closed joint stock company

Drugstore of IFC

  • Betagistin tbl 16 mg No. 30 *, Kanonfarm Production Zaorossiya
  • Betagistin tbl 24 mg No. 20, Zaorossiya's Vertexum
  • Betagistin tbl 16 mg No. 30, Zaorossiya's Vertexum
  • Betagistin tbl 24 mg No. 20, Kanonfarm Production Zaorossiya
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Apteka24

  • Betagistinlugansky HFZ (Ukraine, Luhansk)
  • Betagistin
  • Betagistin of the tab. of 16 mg N30medokhemi (Cyprus)
  • Betagistin-ratiofarm of a tablet 16 of mg No. 30ratiofarm (Germany)
  • Betagistin-ratiofarm of a tablet 24 of mg No. 20ratiofarm (Germany)

BIOSPHERE

  • Betagistin-ratiofarm of 16 mg No. 30 of table.
  • Betagistin-ratiofarm of 24 mg No. 30 of table.
  • Betagistin-ratiofarm of 24 mg No. 60 of table.
  • Betagistin-ratiofarm of 16 mg No. 60 of table.
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Section: For a nervous system
in more detail

Education: East Kazakhstan state university of S. Amanzholov, Ust-Kamenogorsk. Specialty "Valueology".

PAY ATTENTION! Information on drugs on the website is help generalizing, collected from public sources and can form the basis for making decision on use of medicines it is not aware of treatment. Before medicine use Betagistin surely consult with the attending physician.