Betaksolol

Бетаксолол Drug photo

The description is actual on 10.11.2015

  • Latin name: Betaxolol
  • ATH code: C07AB05
  • Active ingredient: Betaksolol (Betaxolol)
  • Producer: Moscow endocrine plant (Russia)

Structure

The white tablet contains 20 mg of active ingredient of a hydrochloride of Betaksolol in a film cover.

Additional components: Na carboxymethylstarch, Mg stearate, microcrystallic cellulose, monohydrate of lactose, aerosil.

Structure of a cover: polyvinyl alcohol, white opadray-2, titanium dioxide, talc and macrogoal.

1 ml of drops contains 5 mg of active agent of a hydrochloride of Betaksolol.

Additional components: Na hydroxide, chloride benzetoniya, dihydrate of an edetat of dinatrium, Na chloride, water, Acidum hydrochloricum.

Release form

Tablets

Round form in a film cover, with risky, biconvex, a white color. On a section the white kernel is visualized (single impregnations of other flowers are allowed). Tablets Betaksolol are packed on 10 pieces into blisters. In a pack from a cardboard there is an instruction and blisters (1-10).

Eye drops

Slightly yellowish, almost transparent liquid. The tube dropper (1.5-5 ml) is issued in special bottles droppers (5-10 ml) with a sterile cover. In a pack from a cardboard there is an instruction and 1 bottle dropper.

Pharmacological action

Active component — beta 1 - the adrenoblocker (cardioselective) which is not possessing sympathomimetic internal activity. Slight membranostabiliziruyushchy influence is characteristic of active ingredient.

Betaksolol has hypotensive effect which is reached due to reduction of the stimulating sympathetic impact on peripheral located vessels, and also due to decrease in minute cordial volume.

Cardiodepressive influence is not characteristic of therapeutic dosages. Active component does not promote a delay of ions of Na in an organism, does not reduce bronchodilatory activity of beta-adrenergic agonists, does not exert impact on a glucose metabolism. Long influence is characteristic.

Eye drops at topical administration are capable to reduce an indicator of intraocular pressure. Resorptive activity is expressed slightly.

Pharmacodynamics and pharmacokinetics

95% of the dose accepted by per os quickly are absorbed from a gleam of a digestive tract. The effect of "the first passing" through hepatic system is characteristic. The indicator of Cmax is registered in 1-2 hours. Contacts plasma proteins for 50%. The indicator of Vd is equal to 6 l/kg. The elimination half-life is equal to 15-20 hours. A preferential way of removal of metabolites – through renal system; about 10-15% of a medicine are removed in original state.

Indications to use

In ophthalmology eye drops Betaksolol are appointed:

  • after the made laser trabekuloplastika;
  • at the increased level of intraocular pressure;
  • at an open-angle form of glaucoma (a chronic current).

System use:

Contraindications

  • dekompensirovanny form of chronic heart failure (at inefficiency of APF inhibitors, inotropic means, diruteichesky medicines, other vazodilatator);
  • cardiogenic shock;
  • Printsmetal's stenocardia;
  • atrioventricular blocks 2 and 3 degrees in the absence of the implanted electrocardiostimulator;
  • acute heart failure;
  • heavy current of HOBL, bronchial asthma;
  • the expressed pathology from peripheral blood supply;
  • the expressed bradycardia with pulse of 45-50 beats per minute and less;
  • sinuatrial blockade;
  • SSSU;
  • anaphylactic reactions at the patient in the anamnesis;
  • individual hypersensitivity to Betaksolol;
  • age restrictions – till 18 flyings;
  • Floktafenin and Sultoprid's concomitant use;
  • cardiomegaly (in the absence of symptoms of heart failure);
  • metabolic acidosis;
  • pheochromocytoma at the patients who are not accepting alpha adrenoblockers;
  • obliterating pathology of peripheral located arteries;
  • severe form of a Raynaud's disease;
  • arterial hypotonia;
  • treatment by MAO inhibitors.

Side effects

Sense bodys, nervous system:

Urinary path:

  • renal gripes;
  • oliguria;
  • impotence;
  • cystitis;
  • fibrous and cystous changes in mammary glands with a pain syndrome at women;
  • proteinuria;
  • dysuria;
  • Peyroni's illness;
  • prostatitis;
  • decrease in a libido;
  • disturbances of a menstrual cycle;
  • puffiness.

Cardiovascular system:

  • change of a trophicity of a myocardium;
  • bradycardia;
  • hypotonia;
  • atrioventricular block;
  • heartbeat;
  • purpura;
  • exacerbation of the alternating lameness;
  • heart failure;
  • thrombosis;
  • leukocytosis;
  • anemia;
  • hypertension;
  • thrombocytopenia;
  • myocardial infarction.

Digestive tract:

  • locks;
  • dysphagy;
  • nausea;
  • dispepsichesky frustration;
  • epigastric pains;
  • diarrheal syndrome;
  • dryness in an oral cavity;
  • vomiting;
  • anorexia.

Respiratory system:

Other negative reactions:

Negative reactions when using eye drops:

  • xerophthalmus;
  • dacryagogue;
  • system reactions;
  • spotty okrashennost of a cornea;
  • anisocoria;
  • photophobia;
  • feeling of a foreign body in an eye;
  • sight misting;
  • decrease in sensitivity of an eye;
  • itch;
  • pain syndrome.

Betaksolol, application instruction (Way and dosage)

The tableted form is intended for system use, and eye drops – for local.

Tablets appoint per os on 20 mg a day. To patients who are on a dialysis (peritoneal) a hemodialysis (constant), originally appoint 10 mg a day. The choice of time of reception is carried out depending on the mode of holding dialysis sessions.

Drug Betaksolol in the form of eye drops is appointed twice a day on 1 drop in the affected eye. The first month of therapy demands obligatory control over an indicator of intraocular pressure. Further measurement of this parameter is carried out in an individual order.

Overdose

Use of high doses can provoke:

  • arrhythmia;
  • acute heart failure;
  • bradycardia;
  • dizziness;
  • hypoglycemia;
  • convulsive syndrome;
  • collapse;
  • hypotonia.

At poisoning carrying out actions for washing of a digestive tract is required, purpose of enterosorbiruyushchy medicines is effective (Polisorb, Absorbent carbon). At cordial blockade carrying out transvenous stimulation is possible. As symptomatic therapy intravenously enter 1-2 mg of Atropine, cardiotonics (Dobutaminum, the Dopamine, Epinephrinum, Norepinephrinum), beta-adrenergic agonists (Izoprenalin), sedatives (Diazepam, Lorazepam). The hemodialysis is recognized as ineffective.

Interaction

Decrease in efficiency of Betaksolol at simultaneous therapy is noted by Xanthine derivatives, at treatment of an adrenomimetikama. Absorption of active agent considerably decreases at reception of antidiarrheal medicines and antacids. Other anti-hypertensive drugs strengthen hypotensive influence of a medicine. Strengthening of a negative inotropic effect when using galogensoderzhashchy narcotic means is observed.

Betaksolol is capable to prolong action of not depolarizing muscle relaxants. Glucocorticosteroids and NPVS reduce expressiveness of hypotensive effect of Betaksolol. Cardiac glycosides strengthen bradycardia, characteristic of a medicine. The risk of development of an orthostatic form of hypotonia increases at treatment by tricyclic antidepressants (Imipraminum).

Disturbance of conductivity and strengthening of expressiveness of negative inotropic impact at topical administration of eye drops at patients with glaucoma which at the same time accept Verapamil, Amiodaronum, beta adrenoblockers, Diltiazem is possible. Betaksolol is capable to increase concentration of Lidocaine in blood. Sulfasalazinum increases Betaksolol's level in blood. Strengthening of bradycardia and noticeable lowering of blood pressure at reception of the medicines capable to exhaust stocks of catecholamines is noted (including Reserpinum).

Terms of sale

The medicine is released in pharmaceutical points. It is optional to show the prescription form.

Storage conditions

Restriction on temperature condition – to 25 degrees. It is recommended to store in the dark place.

Period of validity

3 years.

Special instructions

At a medium-weight current of HOBL, bronchial asthma therapy by Betaksolol is begun with small dosages, controlling indicators of functions of external respiration. Attacks are stopped beta 2 - adrenomimetikami. At stenocardia, an ischemic heart disease cancellation of a medicine is carried out gradually.

Active agent is not capable to change the pupil size therefore to patients who suffer from a zakrutougolny form of glaucoma in addition appoint miotik. System reactions, and also the additive effects from intraocular pressure at a simultaneous primeniye of the eye drops containing Betaksolol and reception of per os of beta adrenoblockers are possible. Before planned operative measures medicine is cancelled.

Carrying contact lenses when using eye drops Betaksolol is inadmissible. It is not recommended to apply in pediatric practice.

Betaksolol's analogs

Eye drops:

  • Betalmik ES;
  • Betoftan;
  • Ksonef;
  • Betoptik.

Tablets:

Zdravzona

  • Betaksolol of 20 mg No. 30 tabletkimoskovsky endocrine plant of federal state unitary enterprise
  • Betaksolol of 0,5% eye drops of 5 ml bottle-kapelnitsamoskovsky endocrine plant of federal state unitary enterprise
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Section: For eyes Cardiological Cardiovascular
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Education: Graduated from the Bashkir state medical university majoring in "Medical business". In 2011 gained the diploma and the certificate in Therapy. In 2012 received 2 certificate and the diploma in "Functional diagnosis" and "Cardiology". In 2013 completed courses on "Topical issues of otorhinolaryngology in therapy". In 2014 completed advanced training courses in "A clinical echocardiography" and courses in "Medical rehabilitation".

Experience: From 2011 to 2014 the Policlinic No. 33 Ufa worked as the therapist and the cardiologist in MBUZ. Since 2014 the Policlinic No. 33 Ufa works as the cardiologist and the doctor of functional diagnosis in MBUZ.

PAY ATTENTION! Information on drugs on the website is help generalizing, collected from public sources and can form the basis for making decision on use of medicines it is not aware of treatment. Before medicine use Betaksolol surely consult with the attending physician.