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Bilirubin is one bilious pigments, decomposition product of hemoglobin and other components of blood. Blood test on bilirubin allows to learn how the liver works, it is obligatory at diagnosis of many diseases of a gastrointestinal tract.
Direct bilirubin, that is connected, and indirect, free, make the general bilirubin, their concentration makes 25 and 75% respectively. In the course of circulation on an organism bilirubin connects to various chemicals, getting, eventually, into intestines. There under the influence of microflora it practically all turns into urobilinigen which part reabsorbirutsya mucous intestines and again gets to a blood channel.
In small amounts bilirubin contains in a blood plasma, its normal concentration at healthy people makes about 5 — 25 µmol/l., data can vary for various laboratories. Level of content of bilirubin in blood depends on some factors:
Albumine level in blood
Outflow of bile from a liver (can arise at tumors and metastasises in pchen, cirrhosis, Kriglera-Nayar the first syndrome and the second type, Dabin-Johnson's syndrome, acute and chronic hepatitis, poisoning with toxic substances, etc.)
Intensity and massiveness of an erythrocytolysis (it is observed at morbid conditions, diseases: hemorrhages, malaria, anemia, heart attack of lungs, infections, some medicines)
Activities of fermental systems
Any disturbance will bring in the above-stated phenomena on increase of this element.
The bilirubinemia – the general name of increase of amount of bilirubin, in this case occurs adjournment of a pigment in integuments that causes so-called jaundice: yellowing of integuments, scleras of eyes, mucous membranes. Increase in the general level of bilirubin in blood can is connected as with the increased level, both a direct, and indirect pigment.
Newborns can have a physiological jaundice because of increase of an indirect bilirubin, such phenomenon is noted practically at all children in pervyeneskolko days of life and it is considered normal.