Binafin

Бинафин Drug photo

The description is actual on 01.07.2016

  • Latin name: Binafin
  • ATH code: D01BA02
  • Active ingredient: Terbinafin (Terbinafine)
  • Producer: Shreya Layf Sayensiz Pvt. Ltd. (India)

Structure

In 1 tablet of a terbinafin — 125 mg and 250 mg. MKTs, starch, sodium methylparaben, povidone, silicon dioxide, sodium lauryl sulfate, magnesium stearate, sodium glikolit starch, talc as excipients.

In 1 g of cream of a terbinafin of a hydrochloride — 10 mg. Alcohol ketosterilovy, white paraffin, methylparaben, liquid paraffin, propylparaben, sodium acid phosphate, ketomacrogoal, water as excipients.

Release form

Tablets of 125 mg and 250 mg, cream 1%v tubas on 30 g, 15 g and 10 g.

Pharmacological action

Antifungal.

Pharmacodynamics and pharmacokinetics

Pharmacodynamics

Terbinafin has a broad spectrum of activity concerning mushrooms of the dermatophytes causing diseases of nails, skin and a hair and sort Candida mushrooms. Fungicidal action on mold mushrooms and dermatophytes makes even in low concentration.

Concerning drozhzhepodobny mushrooms — fungicidal or the fungistasis depends on a sort of mushrooms. Action of a terbinafin is in skvalenepoksidaza enzyme inhibition in a mushroom membrane that also her death leads to accumulation of squalene in a cell. At appointment inside in nails, hair, and skin fungicidal concentration of drug are created.

Pharmacokinetics

At a single dose in a dose of 250 mg necessary concentration of drug in blood is created in 2 hours. Extent of linkng with proteins high (99%). Well gets into a thermal layer and concentrates in a corneous layer of skin and nail plates. For the 2nd day of reception concentration increases in a corneous layer by 10 times, and in 12 days of reception — by 70 times. Gets into sebaceous glands and in hair and follicles high concentration are also created. Stable concentration in fabrics are defined in 10 days. A half-cycle of removal from 24 to 150 days therefore the long time after the reception termination remains in skin and nail plates.

It is metabolized with the assistance of system of P450 cytochrome. As a result of biotransformation the metabolites which do not have antifungal activity are formed. They are brought with urine. Proofs of cumulation of drug are not available. At topical administration 5% of a dose therefore system influence is minimum are soaked up.

Indications to use

Cream:

Tablets:

  • onychomycoses;
  • mycoses of pilar part of the head;
  • candidiases (if expressiveness or prevalence of process cause
    expediency of reception of tablets).

Tablets are not effective in case of multi-colored depriving.

Contraindications

Hypersensitivity. With care it is appointed at liver diseases.

Side effects

The met side reactions are more often:

  • feeling of overflow of a stomach;
  • appetite loss;
  • nausea;
  • abdominal pains;
  • dyspepsia;
  • taste disturbances;
  • diarrhea;
  • rash, urticaria;
  • arthralgia, mialgiya.

Seldom met side reactions:

  • cholestasia;
  • liver failure;
  • Stephens-Johnson's syndrome;
  • epidermal necrolysis;
  • hematologic disturbances (neutropenia, thrombocytopenia, agranulocytosis).

At topical administration of cream reddening, an itch or burning which seldom lead to the treatment termination can be noted. At emergence of the small tortoiseshell it is necessary to stop treatment.

Binafin, application instruction (Way and dosage)

Cream Binafin is shown to adults and children since 12. It is put with a thin layer by 1-2 times a day and slightly rub, taking adjacent sites. The dermatomycosis of a trunk, feet, shins — duration of treatment is 1 week. At candidiasis of skin and multi-colored herpes — 2 weeks. At infections with existence of an intertrigo (in interdigital intervals, in inguinal area, under mammary glands, between buttocks) after putting cream of the place cover with a gauze napkin. In case of treatment, irregular or insufficient on duration, there is a risk of resuming of an infection.

Tablets Binafin

250 mg are recommended to adults once a day. At a dermatomycosis of feet treatment has to last 2-6 weeks. At a dermatomycosis of a trunk and shins – 3-4 weeks. At mycosis of pilar part of the head — 1 month. At skin candidiasis till 4 weeks. The course at an onychomycosis of brushes makes 4-6 weeks, stop — 12 weeks. At the reduced growth rate of nails, there can be more prolonged treatment before growth of a healthy nail.

At elderly people the dose does not change provided that function of a liver or kidneys is not broken. At a renal failure the half dose of drug is appointed. If in the course of treatment abnormal liver functions treatment are noted cancel.

Overdose

Overdose by tablets is shown by a headache, pain in epigastriums, nausea, dizziness. Treatment consists in a gastric lavage and purpose of enterosorbents. The symptomatic treatment is carried out. About overdose cases when using cream it was not reported. At accidental intake, the above described by-effects are possible.

Interaction

Terbinafin slightly suppresses or strengthens clearance of many drugs which metabolism occurs with the participation of P450 cytochrome. Cyclosporine, Tolbutamidum, terfenadin, to triazoles and oral contraceptives belong to such drugs. Also suppresses CYP2D6 metabolism that is important at use of the medicines which are metabolized this enzyme: antidepressants, beta adrenoblockers, serotonin reuptake inhibitors, monoaminooxidase inhibitors. The clearance of a terbinafin accelerates drugs which strengthen a P450 cytochrome metabolism (rifampicin) and is slowed down by those which inhibit it (Cimetidinum). In all cases it is necessary to consider it and to carry out dose adjustment of Binafin.

Medicinal interactions at topical administration are unknown.

Terms of sale

Without recipe.

Storage conditions

Temperature of storage is up to 25 °C.

Period of validity

3 years.

Analogs

Coincidence on the ATH code of the 4th level:

Atifin (tablets, cream), Lamizil (cream, spray), Terbinafin, Terbizil (tablets, cream), Termikon (cream, spray, tablets), Ekzifin (cream, tablets).

About Binafin

One of the most effective antifungal drugs is terbinafin which exceeds other anti-mycotic drugs: azoles, triazoles and half-yen antibiotics. Also it is connected with the fact that azoles render fungistatic effect, and terbinafin — fungicidal. Its efficiency at treatment of onychomycoses which in 94% of all cases are caused by dermatophytes is especially high, and terbinafin is considered as cure of the choice for this disease. This results from the fact that active ingredient quickly gets into a nail plate and remains in these fabrics in high concentration within several months. In this regard, About drug Binafin positive, it is characterized as effective and available drug. According to messages of patients, the onychomycosis course of treatment within 3 months tablets of original drug Lamizil, and the most available — treatment by generics by Terbinoks and Binafin was the most expensive.

  • "… At a fungus of a nail took this pill, the doctor told that cream not to cure thickness of a nail. Drank 1,5 months, then the nail was completely replaced. Already there passed 3 years — the fungus does not return".
  • "… There was a fungus of a nail phalanx, several months treated itrakonazoly — the fungus appeared again until the doctor wrote out Binafin in tablets".
  • "… Ointment Binafin quickly helped at multi-colored herpes. In 4 days there was a small reddening, but the doctor told to smear a week more".
  • "… This cream works Lamizila is not worse at all, quickly relieves of fungus symptoms, but costs twice cheaper".
  • "… The son has a fungus between foot fingers, cream Binafin helped very well! I do not see a difference with dearer Lamizil".
  • "… The dermatologist prescribed cream Binafin at a skin fungus, for a course there was enough packaging. Noticed effect in three days — spots brightened, the peeling is less and the itch disappeared".

Zdravzona

  • Terbinafin-Tev of 250 mg No. 28 tabletkiteva Pharmaceutical
  • Binafin cream of 1% 10 g
  • Binafin of 250 mg No. 14 of a tablet
  • Terbinafin of 250 mg No. 10 tabletkibioky closed joint stock company
  • Terbinafin of 1% cream 30gverteks of closed joint stock company

Drugstore of IFC

  • Terbinafin cream of a tube of 1% 15 g, Zaorossiya's Vertexum
  • Terbinafin cream of a tube of 1% 30 g, Zaorossiya's Vertexum
  • Terbinafin tbl 250 mg No. 10, Zaorossiya's Vertexum
  • Terbinafin ointment of a tube of 1% 15 g, Moscow FF (г.Москва) Russia
  • Terbinafin-Tev tbl 250 mg No. 28, Tevaizrail
to show still

Apteka24

  • Terbinafin-kv tablets 250 of mg No. 14 Kiev vitamin plant (Ukraine, Kiev)

Paniapteka

  • Terbinafin-kv table of 250 mg No. 14
Section: Dermatological Antifungal
in more detail

Education: Graduated from Sverdlovsk medical school (1968 - 1971) as "Paramedic". Graduated from the Donetsk medical institute (1975 - 1981) as "An epidemiologist, a hygienist". Passed postgraduate study in the Central scientific research institute of epidemiology Moscow (1986 - 1989). An academic degree – the candidate of medical sciences (degree is awarded in 1989, protection – the Central scientific research institute of epidemiology Moscow). Numerous advanced training courses are studied in epidemiology and infectious diseases.

Experience: Work as the manager of department of disinfection and sterilization of 1981 - 1992. Work as the manager of department of especially dangerous infections of 1992 - 2010. Teaching activity at Medical institute 2010 - 2013.

PAY ATTENTION! Information on drugs on the website is help generalizing, collected from public sources and can form the basis for making decision on use of medicines it is not aware of treatment. Before medicine use Binafin surely consult with the attending physician.