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Ibuprofen, paracetamol, calcium hydrophosphate, corn starch, povidone, the purified talc, propylene glycol, gipromelloz titanium dioxide, sodium lauryl sulfate, isopropanol, dye, a macrogoal, the purified water.
Tablets biconvex an oval form in a film cover of orange color in the blister in a cardboard pack No. 10.
Suspension for intake in a bottle of dark glass 60 or 100 of ml in cardboard packaging.
Antiinflammatory, analgeziruyushchy, febrifugal.
Pharmacodynamics and pharmacokinetics
Drug with the combined action. The ibuprofen — at the heart of the mechanism of antiinflammatory action is process of inhibition of activity of TsOG (tsiklogenaz) and suppression of synthesis of prostaglandins.
Paracetamol — carries out blocking of TsOG in TsNS, influencing the centers of thermal control and pain, has febrifugal effect and analgeziruyushchy.
The ibuprofen is quickly absorbed from a stomach, meal slightly reduces absorption. Tmax makes one hour. High communication with proteins of plasma. Substance is slowly distributed and removed from synovial fluid.
It Biotransformirutsya by a carboxylation and a hydroxylation in a liver where turns into an active S-form. The elimination is carried out in two stages. The period of full removal from an organism — is excreted one days with urine in not changed look.
Paracetamol is completely soaked up from a stomach. Communication with blood proteins about 15%. Time of achievement of Cmax one hour. In fabrics and liquids of an organism it is distributed evenly. Gets through GEB. It Biotransformirutsya in a liver with formation of inactive metabolites. It is removed with urine in the form of conjugates.
Indications to use
- Treatment infectious and inflammatory and the acute respiratory diseases proceeding with the expressed fever and also in cases of existence of post-inoculative reactions;
- Stopping of a pain syndrome of moderate intensity at migraine, a lumbago, head and a dentagra, a mialgiya, neuralgia, at a tendovaginitis, an arthralgia, an osteoarthrosis, gout, algodismenore, at diseases of ENT organs, injuries of a musculoskeletal system and soft tissues (fractures, stretchings, bruises, postoperative pain);
- In the form of suspension drug is appointed to children since 2 for the purpose of fall of temperature at ORZ, tonsillitis, at diseases of upper parts of respiratory tracts, flu, post-inoculative reactions, and also for stopping of pain at a dentagra, injuries, a pharyngalgia and in ears, neuralgia.
High sensitivity, to active components of drug, the rhinitis, urticaria provoked by the use of HP, containing acetylsalicylic acid or other NPVP, a renal/liver failure, a gastrointestinal tract canker, a hyperpotassemia, age till 12 flyings (tablet), the lactation period, the III trimester of pregnancy.
To take with caution at arterial hypertension, heart failure, a diabetes mellitus, BS, diseases of peripheral vessels, an alcoholism, a hyperbilirubinemia, cirrhosis, in I and II trimesters of pregnancy, at advanced age, at gastritis, anemia.
Pains in an epitastriya, nausea, vomiting, local allergic reactions, dizziness, a headache, visual disturbances, a leukopenia, thrombocytopenia, anemia, hypostases, disturbance of functions of kidneys.
Brustan, application instruction (Way and dosage)
Brustan to take a pill after food on 1 tabletke3-4 once a day. Duration of reception is defined by efficiency of effect of drug. In the absence of effect reception to stop and see behind consultation a doctor.
Carefully to stir up suspension before the use. For measuring off of a dose to use the measured spoon which is applied to drug.
The dose depends on age and the body weight of the child. Treatment duration: as an antipyretic — no more than 3 days; as anesthetic — no more than 5 days.
Joint inclusion of Brustan with anticoagulants strengthens risk of hemorrhagic complications. Inclusion of Brustan along with anti-hypertensive means and diuretics reduces their efficiency. Brustan increases concentration of a methotrexate, digoxin, lithium and Phenytoinum in a blood plasma.
Inductors of a microsomal oxidation (ethanol, Phenytoinum, rifampicin, antidepressants tricyclic, barbiturates, phenylbutazone) increase a producing hydroxylated metabolites, thereby increasing risk of development of the expressed hepatotoxic reactions. Brustan strengthens side effect of glucocorticosteroids and mineralokortikosteroid.
Categorically administration of drug together with the drinks containing alcohol is not allowed. Myelotoxic HP strengthen risk of manifestation of a gematotoksichnost of Brustan.
Tsefamandol, valproic acid, tsefoperazon, plikamitsin, tsefotetan increase risk of development of a prothrombinopenia.
Terms of sale
At a temperature up to 25 °C.
Period of validity
Analogs of Brustan
Coincidence on the ATH code of the 4th level:
About drug among visitors of forums favorable.
"… In the winter, skiing, I fell and strongly injured sheaves and muscles of an ankle. The joint swelled up, there were severe pains in the place of a bruise, and later — temperature slightly increased. Called an ambulance, applied a pressure bandage and appointed the drug Brustan. In 5 days the tumor disappeared, and temperature was normalized".
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PAY ATTENTION! Information on drugs on the website is help generalizing, collected from public sources and can form the basis for making decision on use of medicines it is not aware of treatment. Before medicine use Brustan surely consult with the attending physician.