Budenit Steri-Neb

Буденит Стери-Неб Drug photo

The description is actual on 04.07.2016

  • Latin name: Budenit Steri-Neb
  • ATH code: R03BA02
  • Active ingredient: Budesonid (Budesonide)
  • Producer: IVAX Pharmaceuticals UK Limited (Great Britain)

Structure

Budesonid, polysorbate, sodium chloride, sodium citrate dihydrate, monohydrate of citric acid, dinatrium edetat, sterile water.

Release form

Suspension 0,25 and 0,5 of mg/l for inhalations: a finely divided consistence of white color, inodorous in the polyethylene ampoules soldered in the form of the block on 2 ml in the laminated foil in a cardboard pack No. 20.

Pharmacological action

Antiinflammatory, anti-exudative, antiallergic.

Pharmacodynamics and pharmacokinetics

Pharmacodynamics

Drug for topical administration, has antiallergic and antiinflammatory effect. Strengthens products of inhibitor of a phospholipase of A2 (lipokortin), slows down process of release of arachidonic acid and synthesis of products of its metabolism. Reduces exudation of inflammatory process, reduces intensity of granulation and an infiltration, slows down migration of macrophages and forming of a chemotaxis, interferes with allocation of mediators of an inflammation from cells that plays an important role in origins of symptomatology of allergic chronic rhinitis.

Drug does not possess ISS activity, is well transferred by patients at long use, has no resorptive effect.

Pharmacokinetics

Budesonid after inhalation is quickly adsorbed, system bioavailability of drug after inhalation via the nebulizer makes about 15% of the arrived dose. In blood the maximum concentration is reached on average in 30 minutes. Linkng with blood proteins high.

Biotransformation of a budesonid happens to participation of an isoenzyme of a liver of CYP3A4. The main metabolites possess extremely weak pharmacological activity. Drug by kidneys in mainly in the form of metabolites (do70%) and in insignificant quantity (about 10%) through intestines is removed.

Indications to use

  • as basic drug at treatment of bronchial asthma (in case of weak efficiency of beta2-adrenomimetik, in the absence of a possibility of use of drug in an inhaler, for decrease in a dosage of peroral GKS);
  • treatment of HOBL (chronic obstructive pulmonary disease);
  • at the stenosing laryngotracheitis.

Contraindications

High sensitivity to drug, infections of a respiratory organs of a virus, fungal and bacterial etiology, a lactation, pregnancy (drops), age till 6 months.

Side effects

Are shown mainly in the form of local reactions on a mucous nasal cavity (dryness, burning, irritation). Cold, an atrophy or an ulceration mucous a nose, bleeding from a nose, irritation in a throat, sneezing, a pharyngalgia, a headache, allergic reactions on skin, perforation of a nasal partition, a mialgiya, a conjunctiva hyperemia, a nose congestion, drowsiness, cough, nausea, vomiting, heartbeat, candidiasis of a mucous nasal cavity and a throat, growth delay.

Steri-Neb, the application instruction (Way and dosage) Budenit

The drug is administered is inhalation through an inhaler nebulizer. Before its use it is necessary to study carefully the instruction and technology of work with it.

The recommended daily dosage of drug at a severe form of bronchial asthma for inhalation GKS-therapy, for adults and children is more senior later than 12 years makes 1–2 mg twice a day, a maintenance dose — 0,5–4 mg a day. Aged from 6 months and till 12 flyings the daily dosage fluctuates from 0,25 to 0,5 mg twice a day, a maintenance dose — 0,25–2 mg a day. If the appointed dose no more than 1 mg/days, then it is possible to accept it at one time.

As a rule, the maintenance dose is selected the doctor individually, at the same time, at achievement of medical effect, it should be reduced to the smallest effective dose. In need of strengthening of medical effect, a dose of drug it is possible can be the combined administration of drug with peroral GKS is increased or is recommended.

Overdose

Clinically expressed symptomatology at acute overdose by drug does not arise.

Interaction

At a concomitant use with Phenobarbital, Phenytoinum, Rifampicin efficiency of drug Budenit Steri-Neb decreases. At a concomitant use of drug with Metandiyenon, Ketokonazol and estrogen, on the contrary, raises.

Terms of sale

According to the recipe.

Storage conditions

At a temperature no more than 25 °C.

Period of validity

24 months.

Budenit Steri-Neb's analogs

Coincidence on the ATH code of the 4th level:

Apulein, Budekort, Gorakort, Benakort, Budesonid, Benarin, Budenofalk, Buderin, Tsikortid Tsiklokaps, Budieyr, Pulmikort, Tafen Nazal.

Zdravzona

  • Budenit Steri-Neb suspension for inhalation 0,5mg/ml 2 ml No. 60 ampulyteva Pharmaceutical
  • Budenit Steri-Neb suspension for inhalation 0,25mg/ml 2 ml No. 20 ampulyteva Pharmaceutical
  • Budenit Steri-Neb suspension for inhalation 0,5mg/ml 2 ml No. 20 ampulyteva Pharmaceutical
  • Budenit Steri-Neb suspension for inhalation 0,25mg/ml 2 ml No. 60 ampulyteva Pharmaceutical

Drugstore of IFC

  • Suspension for ing 0.5mg/ml Budenit steri-neb 2 ml No. 60 of IVAX Corporationchekhiya
  • Suspension for ing 0.5mg/ml Budenit steri-neb 2 ml No. 20 of IVAX Corporationchekhiya
  • Suspension for ing 0.25mg/ml Budenit steri-neb 2 ml No. 20 of IVAX Corporationchekhiya
  • Suspension for ing 0.25mg/ml Budenit steri-neb 2 ml No. 60 of IVAX Corporationchekhiya
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Education: Graduated from Sverdlovsk medical school (1968 - 1971) as "Paramedic". Graduated from the Donetsk medical institute (1975 - 1981) as "An epidemiologist, a hygienist". Passed postgraduate study in the Central scientific research institute of epidemiology Moscow (1986 - 1989). An academic degree – the candidate of medical sciences (degree is awarded in 1989, protection – the Central scientific research institute of epidemiology Moscow). Numerous advanced training courses are studied in epidemiology and infectious diseases.

Experience: Work as the manager of department of disinfection and sterilization of 1981 - 1992. Work as the manager of department of especially dangerous infections of 1992 - 2010. Teaching activity at Medical institute 2010 - 2013.

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