Synacthenum of Depot

Cинактен Депо Drug photo

The description is actual on 15.07.2016

  • Latin name: Synacthen depot
  • ATH code: H01AA02
  • Active ingredient: Tetrakozaktid (Tetracosactide)
  • Producer: Nycomed Austria (Austria); Ciba-Geigy (Switzerland)


In 1 ml of suspension of 1 mg of a tetrakozaktid of hexaacetate.

Release form

Suspension for intramuscular introduction in ampoules on 1 ml.

Pharmacological action

Stimulator of corticotropic hormones.

Pharmacodynamics and pharmacokinetics


The synthetic polypeptide having properties of natural endogenous corticotropinadrenocorticotropic hormone. Stimulates in adrenal glands synthesis of steroids (GKS and ISS) from cholesterol, to a lesser extent influences synthesis of androgens.

The mechanism of action is connected with communication with receptors of cells of bark of adrenal glands with education hormone - a receptor complex which activates adenylatecyclase. As a result of it formation of the cyclic AMF activating a protein kinase amplifies. The last promotes synthesis of a pregnenolon of which highways are formed.

Drug has immunodepressive and antiinflammatory effect, influences all types of an exchange.


Absorption on zinc phosphate provides slow release of active ingredient and long action. After intramuscular use cortisol level in blood remains at the increased level of 24-36 hours. It is split at first by endopeptidases (trypsin, kallikrein, plasmin, thrombin) to inactive oligopeptid, then aminopeptidases to amino acids. It is removed by kidneys.

Indications to use


  • infectious diseases;
  • hypersensitivity;
  • acute psychoses;
  • heavy current of an idiopathic hypertensia;
  • peptic ulcer in an aggravation stage;
  • acute endocarditis;
  • Icenco-Cushing syndrome;
  • refractory HSN;
  • neonatality period;
  • premature children;
  • pregnancy.

With care it is appointed at a diabetes mellitus, bronchial asthma, a myasthenia, an intestines anastomosis, nonspecific ulcer colitis, osteoporosis.

Side effects

  • decrease in body resistance to infections;
  • allergic reactions;
  • increase of the ABP;
  • hypostases;
  • hypopotassemia, hyperglycemia;
  • "steroid" myopathy;
  • osteoporosis;
  • mental disturbances;
  • round ulcer;
  • xanthopathy;
  • itch, rash in an injection site;
  • growth inhibition and hypertrophy of a myocardium (at children who receive treatment it is long).

Synacthenum of Depot, application instruction (Way and dosage)

Suspension is entered only intramusculary. Before an injection the ampoule needs to be stirred up well. In acute cases treatment is begun with daily use, and in 3 days passed to intermittent therapy. Minimum effective dose is appointed, and decrease in a dosage is carried out gradually.

The adult appoint 1 mg/days, after disappearance of acute symptoms — on 1 mg of times in 3 days. At achievement of effect the dose decreases — to 0,5 mg there are each 3 days.

To children of chest age — to 0,25 mg/days there are each 2-8 days depending on a disease and a condition of the child. To children of younger age — 0,25-0,5 mg/days.

In case of use of drug with the diagnostic purpose, define concentration of 17 hydroxycorticosteroids before and after an injection in oil (0,25 mg) in 30 min. If their concentration increases by the 200th nmol/l and more, function of bark of adrenal glands is considered normal.


Overdose is shown by a liquid delay, development of a syndrome of Kushinga. Treatment by drug either is stopped, or reduce its dose. Symptomatic therapy is carried out.


Ketokonazol at simultaneous use with Tetrakozaktid weakens his influence on adrenal glands. Tetrakozaktid in turn weakens effect of hypoglycemic and hypotensive drugs.

Terms of sale

According to the recipe.

Storage conditions

Temperature is 2-8 °C.

Period of validity

3 years.


Corticotropin, Tetrakozaktid.

About Synacthenum of Depot

Drugs AKTG are appointed with the diagnostic purpose, after prolonged use of glucocorticoids on purpose in stimulation of bark of adrenal glands which is oppressed by reception of glucocorticoids. Now use synthetic analog of AKTG tetrakozaktriny which main advantages is the insignificant quantity of side effects. At the same time at some patients the expressed hypostases, increase of the ABP and a hypertrichosis are noted. The drug Synacthenum of Depot is used with the medical purpose in complex therapy of bronchial asthma, kollagenoz, a dermatosis, ulcer colitis.

The stimulator of products of corticosteroids is used at not heavy exacerbations of multiple sclerosis. Treatment is carried out by courses as continuous introduction can entail "exhaustion" of adrenal glands. It is appointed in combination with drugs of potassium and diuretics.

At early myoclonic encephalopathy at children, and also Uest's syndrome at once, along with basic antiepileptic drugs, appoint Synacthenum Depot which regulates convulsive activity of a brain. Most often meet About use of drug at these diseases.

  • "... Appointed this drug to the child. When pritivoepileptichesky drugs did not begin to help. He removed spasms, but for a short time (2,5 months)".
  • "… It is very effective about one year. It is impossible to miss chance".
  • "… After the first injection of a spasm at the child disappeared, but he became aggressive and appetite amplified".
  • "… All accepted in a complex, but the fact that Synacthenum helped to struggle with spasms is precisely!!".
  • "… It is much easier for the daughter, intellectual development on the person! Spasms were not several days, yesterday gave only the fifth injection".
  • "… Synacthenum of Depot to the 6th prick did not work, and after the sixth — there passed attacks!".
  • "… To us appointed already the 2nd course. After the first prick there are no spasms. But the child has a mad appetite, constantly hysterics".
  • "… In our case of result zero!!! It did not suit us, spasms proceed".

Usually drug was well transferred if hypersensitivity was noted, then reaction appeared after the first injection (weakness, an asthma, feeling of heat, the small tortoiseshell). Excitement, sleeplessness, endocrine disturbances, lowering of resilience to infections were the most typical side reactions. At many the water delay in an organism was noted that it is possible to warn an electrolyte-deficient diet. At children of younger age it is regularly necessary to carry out an echocardiography as there is a possibility of emergence of a hypertrophy of a myocardium.

Section: Hormonal
in more detail

Education: Graduated from Sverdlovsk medical school (1968 - 1971) as "Paramedic". Graduated from the Donetsk medical institute (1975 - 1981) as "An epidemiologist, a hygienist". Passed postgraduate study in the Central scientific research institute of epidemiology Moscow (1986 - 1989). An academic degree – the candidate of medical sciences (degree is awarded in 1989, protection – the Central scientific research institute of epidemiology Moscow). Numerous advanced training courses are studied in epidemiology and infectious diseases.

Experience: Work as the manager of department of disinfection and sterilization of 1981 - 1992. Work as the manager of department of especially dangerous infections of 1992 - 2010. Teaching activity at Medical institute 2010 - 2013.

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