Darsil

Дарсил Drug photo

The description is actual on 10.12.2015

  • Latin name: Darsil
  • ATH code: A05BA03
  • Active ingredient: SILYMARINUM (SILIMARINUM *)
  • Producer: CJSC Farmatsevticheskaya Darnitsa firm, Kiev (Ukraine)

Structure

Silymarinum, potato starch, monohydrate of lactose, calcium stearate, sugar, magnesium carbonate, medical, titanium dioxide, talc, silicon dioxide, low-molecular polyvinylpirrolidone, aerosil, wax, dye.

Release form

Tablets of 22,5 mg of rounded shape, coated in strip planimetric packaging in a cardboard pack No. 50 and 100.

Pharmacological action

Gepaprotektornoye.

Pharmacodynamics and pharmacokinetics

Pharmacodynamics

Darsil treats phytodrugs (from seeds of the Thistle spotty) which complex of flavonoidny connections, neutralize negative action of free radicals in a liver and have gepatoprotektorny effect (stabilize membranes of hepatocytes, interfering with destruction of cellular structures).

Drug stimulates synthesis of phospholipids and functional proteins in the injured hepatocytes, activates a RNA polymerase of a cellular kernel, prevents an exit of transaminases (an intracellular component) and accelerate regeneration of hepatic cells. Silymarinum slows down process of penetration of some toxins and poisons into hepatocytes, in particular, of poison of a death angel, blocks production of decomposition products of ethanol – acetic aldehyde.

As a result, heavy feelings in right hypochondrium and weakness at patients with the broken function of a liver decrease, biochemical indicators are normalized, the general state improves.

Pharmacokinetics

Drug Darsil is slowly soaked up from a gastrointestinal tract. In a system blood-groove practically does not contact proteins of plasma. It does not kumulirutsya in an organism. It is metabolized in a liver with education in conjugation tests of glucuronides and sulfates. It is removed with bile, and repeatedly in a system blood stream it is soaked up in a small intestine, carrying out reusable enteropechenochny circulation with gradual fading. The insignificant part of drug is removed with urine. An elimination half-life — 6 hours.

Indications to use

  • Acute and chronic hepatitises of various genesis (including virus), and also postgepatozny states.
  • In therapy of cirrhosis and a fatty infiltration of a liver.
  • Treatment of toxic damages of a liver (poisoning with salts of heavy metals, alcohol, mushrooms, medicines, toxic chemicals).

Contraindications

Hypersensitivity to drug, age till 5 flyings, ulcer and erosive diseases of a gastrointestinal tract in the period of an aggravation, the period of pregnancy and a lactation, insufficiency of lactase, intolerance of a galactose.

To appoint with care at a diabetes mellitus, hormonal disturbances (a carcinoma of a uterus, ovary, milk and a prostate, a hysteromyoma, endometriosis).

Side effects

Drug is well transferred, side effects are noted seldom and are shown:

As a rule, all collateral manifestations, after drug withdrawal completely disappear.

Darsil, application instruction (Way and dosage)

Drug is accepted inside, without chewing, after meal, washing down with water. The dose recommended for adults and teenagers makes 1–2 tablets 3 times a day. For children of 5-12 years the daily dose (3 mg/kg of weight) is divided into 2–3 receptions. Duration of reception is defined individually depending on a look and the course of a disease. On average, duration of treatment makes three months.

Overdose

Drug strengthens action antiallergic (Feksofenadin), anticoagulants (Warfarin, Klopidogrel), gipokholesterinemichesky (Lovastatin), antifungal (Ketokonazol), antipsychotic (Lorazepam, Diazepam) and a number of antineoplastic HP.

Silymarinum reduces efficiency of drugs for estrogenzamestitelny therapy and oral contraceptives at their co-administration.

Interaction

Clinically expressed signs of interaction of drug with other HP it is not established.

Terms of sale

Without recipe.

Storage conditions

At a temperature up to 25 °C.

Period of validity

2 years.

Analogs

Karsil, Gepaleks, Karsil forte, Legalonum, Geparsil, Gipoglisil, Silim and others.

About Darsile

About drug generally positive.

"… That year transferred a severe form of pneumonia, and it is long accepted antibiotics. After an extract pains in a liver developed. Appointed tablets Darsil. After a reception course the liver was recovered, pains disappeared. Drug actually good, I recommend. In drugstores often offer more expensive analog — Karsil. But why to overpay?"

Darsil's price where to buy

Darsil's price of 0,225 mg No. 50 varies in drugstores of Ukraine within 48 - 55 hryvnias for packaging; No. 100 — 86-97 hryvnias. In Moscow the average price of Darsil No. 50 makes 190 rubles for packaging; No. 100 — about 300 rubles. It is possible to buy drug in the majority of drugstores of Moscow according to the pre-order.

Apteka24

  • Darsil No. 100darnitsa tablet 0.035g (Ukraine, Kiev)
  • Darsildarnitsa (Ukraine, Kiev)

Paniapteka

  • Darsil of the tab. 0.035g No. 100darnitsa
  • Darsil of the tab. 0.035g No. 100darnitsa
Section: For a liver
in more detail

Education: Graduated from Sverdlovsk medical school (1968 - 1971) as "Paramedic". Graduated from the Donetsk medical institute (1975 - 1981) as "An epidemiologist, a hygienist". Passed postgraduate study in the Central scientific research institute of epidemiology Moscow (1986 - 1989). An academic degree – the candidate of medical sciences (degree is awarded in 1989, protection – the Central scientific research institute of epidemiology Moscow). Numerous advanced training courses are studied in epidemiology and infectious diseases.

Experience: Work as the manager of department of disinfection and sterilization of 1981 - 1992. Work as the manager of department of especially dangerous infections of 1992 - 2010. Teaching activity at Medical institute 2010 - 2013.

PAY ATTENTION! Information on drugs on the website is help generalizing, collected from public sources and can form the basis for making decision on use of medicines it is not aware of treatment. Before medicine use Darsil surely consult with the attending physician.