Deksa-Gentamitsin

Декса-Гентамицин Drug photo

The description is actual on 01.07.2016

  • Latin name: Dexa-Gentamicin
  • ATH code: S01CA01
  • Active ingredient: Gentamycin + Dexamethasone (Gentamicin + Dexamethasone)
  • Producer: Ursapharm Arzneimittel GmbH & Co. KG (Germany)

Structure

Oculentum: dexamethasone, gentamycin sulfate, vaseline white liquid paraffin, lanolin.

Drops are eye: sodium dexamethasone phosphate, Gentamycini sulfas, chloride a benzalkoniya, hydropotassium phosphate, dihydropotassium phosphate, sodium chloride, water for injections.

Release form

Oculentum of white color in an aluminum tuba with a polyethylene tip in a cardboard pack of 2.5 g.

Drops eye transparent colourless in a polymeric bottle with a dropper of 5 ml in a cardboard pack.

Pharmacological action

Antibacterial, glucocorticoid, antiallergic, antiinflammatory.

Pharmacodynamics and pharmacokinetics

Pharmacodynamics

The drug Deksa-Gentamitsin contains two well compatible active components in an optimum dosage of each of them.

Gentamycin – we will well dissolve the antibiotic relating to group of aminoglycosides in water. Has the expressed bactericidal effect of rather wide range of gram-positive and gram-negative microorganisms. Through the unimpaired cornea does not get. Inflammations and damages of a cornea of various genesis create an opportunity to penetration into an anterior chamber of an eye through a cornea in 15 minutes after putting drug.

Dexamethasone – has strong antiinflammatory and antiallergic effect. Penetration through the unimpaired cornea into an anterior chamber of an eye, but at damage of an epithelium of a cornea of an epithelium penetration speed through a cornea increases.

Pharmacokinetics

Dexamethasone at topical administration quickly and well gets into fabric of a cornea and a conjunctiva, reaching necessary therapeutic concentration in fluid medium of an eye are reached.

Gentamycin sulfate at topical administration in therapeutic concentration in fluid medium of structures of an eye is found within 6 hours. Through the unimpaired cornea drug does not get into a system blood stream.

Indications to use

The diseases of eyes of infectious and inflammatory genesis caused by the microorganisms sensitive to gentamycin:

  • keratitis, blepharitis, conjunctivitis, barley;
  • the allergic manifestations in front department of an eye proceeding with a consecutive bacterial infection.

Prevention of the inflammatory phenomena in the post-operational period.

Contraindications

  • The increased intraocular pressure;
  • Mikobakterialny infections of eyes;
  • Viral diseases of a conjunctiva and cornea (treelike keratitis, chicken pox);
  • Fungal infections of eyes;
  • The purulent diseases of eyes proceeding with defeat of a corneal epithelium;
  • Epiteliopatiya of a cornea;
  • High sensitivity to drug.

When using the drug Deksa-Gentamitsin it is not recommended to use contact lenses.

Side effects

In practice collateral manifestations are observed extremely seldom, mainly in the form of local allergic manifestations and a burning sensation in eyes after drug use. At long use of drug development of a steroid cataract and secondary glaucoma is possible.

Application instruction (Way and dosage)

The oculentum Deksa-Gentamitsin in the form of a strip about 1 cm long is put in conjunctival polost2-3 once a day. At the same time, during procedure it is necessary not to allow contact of a tube with a surface of a conjunctiva and skin. At purpose of simultaneous use of several eye means, the instruction on an oculentum Deksa-Gentamitsin indicates the need of observance of a time interval between their use not to exchange of 15 minutes.

Eye drops Deksa-Gentamitsin dig in directly in a conjunctival sac in a dosage 1-2 drops of 5-6 times a day. Deksa-Gentamitsin it is not necessary to use more than 3 weeks.

Overdose

Overdose is improbable at topical administration.

Interaction

At a concomitant use with atropine or other cholinergic HP, the risk of increase of intraocular pressure increases. Gentamycin at local appointment cannot be combined with heparin, Amphotericinum In, cefalotin, Sulfadiazinum and kloksatsilliny as at the same time the risk of adjournment in a conjunctival cavity of precipitated calcium superphosphates appears.

Terms of sale

According to the recipe of the doctor.

Storage conditions

Temperature of storage is up to 25 °C.

Period of validity

3 years. Drops after opening of a bottle need to be used within 1,5 months.

Analogs

Coincidence on the ATH code of the 4th level:

The combined eye drops of Betagenot (gentamycin + betamethasone), Tobradeks (Tobramycinum + dexamethasone), Maksitrol (Neomycinum + dexamethasone + polymyxin B), Kombinil-Duo have similar effect (ciprofloxacin + dexamethasone).

Responses

This complex drug in the form of drops and ointment combines antibacterial and antiallergic action. Judging by responses, it was appointed at chronic conjunctivitis, blepharites and blefarokonjyunktivita, in that case when allergic manifestations it is combined with a bacterial infection. It is known that at allergic conjunctivitis sooner or later there is an accession of an inflammation which has chronic character. Drug is effective also at episclerites, an injury of a conjunctiva and cornea, a keratitis. All patients note high performance of ointment and drops which have the expressed antiinflammatory effect.

  • "… The child had a purulent conjunctivitis which treated the whole month a sulfacetamide and levomitsetinovy drops. There was an insignificant result and the inflammation passed to a cornea. Appointed Deksa-gentamitsin ointment. And we began to recover at last".
  • "… Deksa-Gentamitsin ointment to me was appointed at a demodicosis a century when the purulent inflammation joined. Greased for night of 4-5 days — the inflammation passed".
  • "… Good ointment. Used it at an ulcer blepharitis: purulent crusts disappeared in 2 days, and ulcerations of edges a century treated five more days".
  • "… To the husband this ointment helped to cure barley quickly. It is very happy with efficiency of ointment".

Much drops were appointed after ophthalmologic operations, and they successfully prevented postoperative complications. All patients well transferred drug and side reactions were not noted.

Zdravzona

  • Deksa-gentamitsin oculentum 2,5gursafarm Artsnaymittel Gmbh
  • Deksa-gentamitsin drops eye 5 ml bottle-kapelnitsaursafarm Artsnaymittel Gmbh

Drugstore of IFC

  • Deksa-Gentamitsin hl drops. 5 ml, Ursapharm Arzneimittel Gmbhgermaniya
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Apteka24

  • Deksa-gentamitsin eye drops 5mlursafarm (Germany)
Section: Antibiotics For eyes
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Education: Graduated from Sverdlovsk medical school (1968 - 1971) as "Paramedic". Graduated from the Donetsk medical institute (1975 - 1981) as "An epidemiologist, a hygienist". Passed postgraduate study in the Central scientific research institute of epidemiology Moscow (1986 - 1989). An academic degree – the candidate of medical sciences (degree is awarded in 1989, protection – the Central scientific research institute of epidemiology Moscow). Numerous advanced training courses are studied in epidemiology and infectious diseases.

Experience: Work as the manager of department of disinfection and sterilization of 1981 - 1992. Work as the manager of department of especially dangerous infections of 1992 - 2010. Teaching activity at Medical institute 2010 - 2013.

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