Denebol

Денебол Drug photo

The description is actual on 29.07.2016

  • Latin name: Denebol
  • ATH code: M01AH02
  • Active ingredient: Rofekoksib (Rofecoxib)
  • Producer: Mepro Farmasyutikalz Pvt. Ltd. for "Mile Helsker" (India/Great Britain)

Structure

Mg tablets 25 and 50: the rofekoksib, corn starch, microcrystallic cellulose, a beta cyclodextrin, sodium methylhydroxybenzoate, talc purified povidone, silicon dioxide colloid, sodium propilgidroksibenzoat, sodium krakhmalglikolit, magnesium stearate, diamond blue, tartrazine color, starch.

Gel: the rofekoksib, linseed oil, menthol, methyl salicylate, phenoxyethanol, butyl hydroxytoluene, propylene glycol, isopropyl alcohol, the purified water, carbomer, trietanolamine, dinariya edetat, polietilenglikol, the hydrated castor oil, polioksit.

Solution for an injection: rofekoksib.

Suppository: rofekoksib, fish oil.

Release form

Tablets biconvex rounded shape of 25 and 50 mg in the blister packaging in a cardboard pack No. 10.

Gel in a polyethylene tuba in cardboard packaging of 30 g.

Solution for injections in ampoules of 1 ml (25 mg) in cardboard packaging No. 5.

Suppository of 25 mg in polyethylene packaging in a cardboard pack No. 10.

Pharmacological action

Antiinflammatory, febrifugal, anesthetizing, antiedematous.

Pharmacodynamics and pharmacokinetics

Pharmacodynamics

Drug of NPVP group, contains the rofekoksib relating to the substances-inhibitors TsOG-2 with high degree of selectivity of action. The mechanism of antiinflammatory effect of drug is based on oppression of process of production of prostaglandins, TsOG-2 which is carrying out at the expense of inhibition, at the same time, rofekoksib does not suppress TsOG-1 and respectively physiological processes, connected with TsOG-1 in intestines and thrombocytes, fabrics, a stomach are not broken.
Analgeziruyushchy action begins in 10 min. at an injection way of drug, and its peak is observed in 4 hours, then the effect for 24 h decreases.

Drug in the form of gel for topical administration contains methyl salicylate, linseed oil, menthol. Methyl salicylate is effective at local muscular pains, damage of soft tissues, joint pains. Linseed oil belongs to the diemulsified substances and is a component for mitigation at topical administration.

Menthol at external use causes a cryesthesia that leads to stimulation of cold receptors and stabilization in neuronew membranes of a flow of calcium ions.

Pharmacokinetics

Drug is well soaked up in a gastrointestinal tract, bioavailability about 93%. Cmax in blood is defined in 2 hours. High communication with blood proteins (about 87%) is noted, gets through GEB. The drug applied on skin is soaked up very slowly and causing its significant amount on skin in blood does not lead to increase of concentration of actively active ingredient. The Rofekoksib biotransformirutsya in a liver, is removed in the form of metabolites with urine and a stake.

Indications to use

The periarthritis, tendevit, an osteoarthritis, a pseudorheumatism, a bursitis, thrombophlebitis, musculoskeletal system injuries, a pain syndrome of different genesis, a pulpitis, stomatitis, an ulitis, diseases of ENT organs, generative organs and an urinary system, the III trimester of pregnancy.

Contraindications

High sensitivity to drug, allergic reactions to salicylates or NPVP, bronchial asthma, oncological diseases, age till 12 flyings.

Persons are not recommended to appoint intramuscular injections of drug with strokes, myocardial infarctions in the anamnesis, atherosclerosis, the expressed arterial hypertension.

Side effects

Dizziness, drowsiness, block, dyspepsia, heartburn, nausea, pains in epigastric area, is more rare — heart failure, aphthous stomatitis, a Quincke's disease, a skin itch, hypostasis of the lower extremities, urticaria, rash.

Denebol, application instruction (Way and dosage)

Pill Denebol is taken irrespective of meal. The recommended initial dose of drug for stopping of a pain syndrome makes 50 mg once a day, then the dosage decreases to 25 mg of 1 times a day. To accept not to exceed, however, before full stopping of an acute pain syndrome reception duration more than 2 weeks.

Pseudorheumatism and osteoarthritis: the initial recommended dose — 12,5 mg of 1 times a day, if necessary it to be raised to 25 mg. A reception course for 4–6 weeks.

Solution for injections — the drug is administered in oil deeply in a buttock of 1 times a day. The initial recommended daily dose — 50 mg, then a dose can be reduced. Solution for injections is recommended to be used quickly (within a week) with further transition to other forms of drug. At the combined use Denebola with other dosage forms (tablets, gel) the daily dose of drug generally should not exceed 50 mg.

Denebol gel — is applied on a skin site in the struck area and slightly rubbed 3–4 times a day. Duration of treatment depends on effect of use of gel.

Denebol in the form of suppository apply rektalno on one suppository 2 times pass for treatment of primary dysmenorrhea and stopping of an acute pain at inflammatory diseases. Duration of use of candles should not exceed 1,5 months.

Overdose

Drug malotoksichen, the overdoses given about cases are absent.

Interaction

At joint administration of drug with APF inhibitors efficiency of hypotensive therapy sharply decreases. The Rofekoksib cannot be accepted together with the products and HP containing caffeine because of risk of increase of the ABP. Use of a number of antibiotics (Rifamycinum, rifampicin) reduce Denebol's concentration in a blood plasma. Denebol does not exert impact on pharmacokinetics of a ketokonazol, Prednisolonum, digoxin, Cimetidinum, oral contraceptives.

Terms of sale

According to the recipe.

Storage conditions

At a temperature up to 25 °C.

Period of validity

3 years for tablets and 2 years for gel, solution, candles.

Denebol's analogs

Coincidence on the ATH code of the 4th level:

Rofekoksib, Orotiks, Tselebreks, Revmoksib, Diclofenac, Remisid, Ketonal, Naproxenum, Ibuprofen, Traumel, Voltarenum and others.

About Denebole

About drug among the persons who are often using it in the practice positive.

  • "… After works on a kitchen garden the most severe radiculitis began, even rose from a bed with the most severe pains. Advised Denebol's pricks, after the first prick began to rise with a bed and to go, and after the third prick pain disappeared and the movements were recovered";
  • "… Ointment Denebol is my rescuer! I suffer from a pseudorheumatism therefore this drug constantly in my first-aid kit".

Some patients note side effect of drug, is especially frequent from a stomach, in particular gastritises. To avoid a negative impact of drug it is necessary to observe strictly recommended duration of its reception.

Apteka24

  • Denebol gel 30gmili Helskere Limited (Great Britain)
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Paniapteka

  • Denebol gel 30gmili Helskere Limited
  • Denebol gel 30gmili Helskere Limited
Section: Anesthetics
in more detail

Education: Graduated from Sverdlovsk medical school (1968 - 1971) as "Paramedic". Graduated from the Donetsk medical institute (1975 - 1981) as "An epidemiologist, a hygienist". Passed postgraduate study in the Central scientific research institute of epidemiology Moscow (1986 - 1989). An academic degree – the candidate of medical sciences (degree is awarded in 1989, protection – the Central scientific research institute of epidemiology Moscow). Numerous advanced training courses are studied in epidemiology and infectious diseases.

Experience: Work as the manager of department of disinfection and sterilization of 1981 - 1992. Work as the manager of department of especially dangerous infections of 1992 - 2010. Teaching activity at Medical institute 2010 - 2013.

PAY ATTENTION! Information on drugs on the website is help generalizing, collected from public sources and can form the basis for making decision on use of medicines it is not aware of treatment. Before medicine use Denebol surely consult with the attending physician.