Депакин Drug photo

The description is actual on 07.08.2014

  • Latin name: Depakine
  • ATH code: N03AG01
  • Active ingredient: Sodium Valproatum (Natrii valproas)
  • Producer: Sanofi-Winthrop Industrie (France)


Syrup Depakinum (Depakine) contains sodium Valproatum, and also the following auxiliary components in quality of active agent: methylparahydroxybenzoate, sucrose, glitserol, concentrated hydrochloric acid or strong solution of sodium of hydroxide, propilparagidroksibenzoat, sorbitol of 70%, fragrance artificial cherry, the water purified.

Release form

The medicine Depakinum is let out in the form of syrup (in a set a bilateral dosing spoon) and lyophilisate for injections.

Pharmacological action

Anticonvulsant medicine which is effective at various forms of epilepsy.

Pharmacodynamics and pharmacokinetics

Depakinum – anticonvulsant drug which can render sedative and central myorelaxation effect. Increase of concentration in TsNS GAMK (piperidic acid) is the cornerstone of its action that reduces excitability of motor zones of a brain and convulsive readiness. There is also other hypothesis according to which this drug influences sites of postsynaptic receptors, increasing the braking action of GAMK.

Bioavailability of medicine at the peroral use – about 100%. Distribution, mainly, is limited to blood and extracellular liquid. Medicine comes to cerebrospinal liquid and a brain. An elimination half-life – about 8-20 hours (patients at children's age have less). Minimum content of active agent in blood serum which is necessary for therapeutic effect — 40–50 mg/l. At concentration it is higher than 200 mg/l, the dosage needs to be reduced.

Steady concentration in a blood plasma at oral administration is reached in 3-4 days. Strong linkng with proteins of a blood plasma, in many respects depends on a dosage.

Indications to use

Depakinum is appointed at:

  • epilepsies of various origin;
  • febrile spasms at children;
  • maniac-depressive psychosis which has a bipolar current;
  • children's tic;
  • the changes of character and behavior caused by epilepsy;
  • various forms of epileptic seizures;
  • specific syndromes (for example, Vest or Lennox-Gasto).


Drug has the following contraindications:

  • hypersensitivity to medicine components;
  • liver porphyria;
  • liver failure;
  • dysfunctions of a pancreas;
  • pregnancy (especially in the I trimester);
  • lactation period;
  • hemorrhagic diathesis;
  • the expressed thrombocytopenia;
  • acute and chronic hepatitis.

Side effects

At reception of this medicine the following side effects are possible:

  • allergic reactions;
  • Stephens-Johnson's syndrome;
  • confusion of consciousness;
  • nausea;
  • stomach ache;
  • the moderate giperammoniyemiya (which is not influencing work of a liver and not demanding cancellation of a course);
  • thrombocytopenia;
  • easy tremor of hands;
  • vasculitis;
  • increase in body weight;
  • polymorphic erythema;
  • vomiting;
  • diarrhea;
  • reduction of level of fibrinogen or increase in a bleeding time;
  • hair loss;
  • drowsiness;
  • headache;
  • reversible syndrome of Fankoni.

Besides, seldom or never at administration of drug such side effects as were observed:

  • stupor or lethargy;
  • reversible dementia which is connected with a reversible brain atrophy (passes after drug withdrawal);
  • toxic epidermal necrosis;
  • reversible parkinsonism;
  • anemia;
  • leukopenia;
  • macrocytosis;
  • pancytopenia;
  • reversible and irreversible hearing loss;
  • renal failure;
  • amenorrhea;
  • disturbance of a regularity of a menstrual cycle;
  • peripheral hypostases;
  • abnormal liver functions.

Application instruction of Depakinum

The instruction on Depakinum provides administration of drug inside during food. The dosage is established individually, depending on age and the patient's weight.

As a rule, initial day norm for adults and children who weigh more than 25 kg –15 mg/kg, gradually increase it approximately by 5–10 mg/kg every week before achievement of the maximum dosage.

The application instruction of Depakinum provides the following average daily doses:

  • to children — 30 mg/kg/days (it is better to use syrup);
  • to teenagers and adults — 20–30 mg/kg.

At the same time the daily dosage is recommended to divide as follows:

  • patients aged till 1 year – 2 receptions;
  • patients, are more senior than 1 year – 3 receptions.

The big dosing spoon complete with syrup is expected 200 mg, small – 100 mg. Recommend to use medicine only by means of a special dosing spoon.

If before the patient accepted antiepileptic drugs which need to be replaced with Depakinum, it is necessary to do it gradually, approximately within two weeks.

If other antiepileptic drugs were not accepted, the dosage increases every 2-3 day, then the optimum dose is reached approximately in a week.


Overdose of drug is fraught with emergence of a coma of various degree to which hypotonia of muscles, a hyporeflexia, respiratory depression accompanies. Developing of intracranial hypertensia because of brain hypostasis is probable.

At overdose carry out a gastric lavage, control of work of cardiovascular and respiratory systems, and also osmotic diuresis. In especially hard cases carry out a dialysis or exchange hemotransfusion. At high doses even the lethal outcome is possible.


To combine drug with other means which cause spasms or reduce a convulsive threshold, it is not strongly recommended. Many antidepressants, Meflokhin, Tramadol, neuroleptics, Bupropion concern to them. Besides, it is contraindicated to accept at the same time Depakinum with a St. John's Wort. Also combinations with Lamotrigin are not recommended.

Especially carefully and under strict control of the doctor combine medicine with:

  • Carbamazepine;
  • Karbapenemami;
  • Monobaktamami;
  • Felbamatami;
  • Phenobarbital;
  • Primidonum;
  • Phenytoinum;
  • Topiramat.

Together with Nimodipin drug strengthens its hypotensive effect.

Terms of sale

Medicine is released only according to the recipe.

Storage conditions

It is necessary to store drug in the place, unavailable to children, which is well protected from hit solar by the best. Temperature is not above 25 °C.

Period of validity

It is necessary to store Depakinum no more than 3 years.

Responses on Depakinum

Responses on Depakinum report that drug exerts positive impact on mood and a mental condition of patients, at the same time it possesses effective antiarrhytmic action.

Besides, those who accept it, note such widespread side effects as fatigue, a depression, psychosis, irritability and so forth. Doctors recommend to follow strictly the application instruction of drug, then undesirable symptoms can be avoided. In general, responses on syrup for children and adults, even despite existence of some side effects, positive.

Depakinum price where to buy

Depakinum price in Russia makes about 330 rubles. Analogs in the form of tablets, as a rule, are more expensive. Depakinum price in Ukraine – about 40 hryvnias.


  • Depakinum enterik 300 mg No. 100 of a tabletkisanofa Vintrop Indastri
  • Depakinum hrono 300 mg No. 100 of a tabletkisanofa Vintrop Indastri
  • Depakinum hrono 500 mg No. 30 of a tabletkisanofa Vintrop Indastri
  • Depakinum ml syrup 150 fl. Sanof Vintrop Indastri
  • Depakinum of 400 mg lyophilisate for solution complete with solvent 4 of ml No. 4 of amp. Gruppo Lepetit S.R. IT l

Drugstore of IFC

  • Depakinum of a hronosfer gran.prolong 1000 mg pack ice No. 30, Sanofi-Winthropfrantion
  • Depakinum enterik tbl p / about 300 mg No. 100, Sanofi-Winthropfrantion
  • Depakinum of a hronosfer gran.prolong 100 mg pack ice No. 30, Sanofi-Winthropfrantion
  • Depakinum hrono tbl p / about pro-longum of 300 mg No. 100, Sanofi-Winthropfrantion
  • Depakinum of a hronosfer gran.prolong 500 mg pack ice No. 30, Sanofi-Winthropfrantion
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  • Depakinsanofi Winthrop Industrie (France)
  • Depakinum hronosanofi Winthrop Industrie (France)
  • Depakinum enteriksanofi Winthrop Industrie (France)


  • Depakinum Sintelabo syrup 150mlsanofi
  • Depakinum Sintelabo syrup 150mlsanofi
  • Depakinum Sintelabo syrup 150mlsanofi
  • Depakinum Sintelabo syrup 150mlsanofi


  • Depakinum of 5,7% 150 ml syrup Industrie (France)
  • Depakinum hrono 300 mg No. 100 Industrie (France)
  • Depakinum hrono 500 mg No. 30 Industrie (France)
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Section: For a nervous system
PAY ATTENTION! Information on drugs on the website is help generalizing, collected from public sources and can form the basis for making decision on use of medicines it is not aware of treatment. Before medicine use Depakinum surely consult with the attending physician.