Detruzitol

Structure

In 1 tablet of 2 mg or 1 mg of a tolterodin.

Cellulose microcrystallic, starch of sodium glikolit, calcium hydrophosphate, a gipromelloz, magnesium stearate, stearic acid, silicon dioxide, titanium dioxide — as excipients.

In 1 capsule of 4 mg or 2 mg of a tolterodin. Sugar granules, ethyl cellulose, a gipromelloza — as excipients.

Release form

  • Tablets in a cover of 1 mg and 2 mg.
  • Capsules of the prolonged action of 2 mg and 4 mg.

Pharmacological action

M-holinoblokiruyushchee.

Pharmacodynamics and pharmacokinetics

Pharmacodynamics

The selection antagonist of muskarinovy receptors showing high selectivity to bladder receptors. Does not exert the expressed impact on other receptors. Reduces activity of a detruzor (the muscle which is reducing a bubble and pushing out urine), weakens it and reduces spontaneous reductions. The effect comes in 4 weeks. Reduces salivation.

Pharmacokinetics

Absolute bioavailability makes 17%. The maximum concentration is defined in blood in 2-5 hours. Equilibrium concentration in 4 days. concentration increases if to accept drug during food. It is metabolized in a liver by CYP2D6 isoenzyme with formation of an active 5th metabolite which considerably strengthens effect of drug. At insufficiency of an isoenzyme is exposed to dealkylation by other isoenzymes with formation of an inactive metabolite. Insufficiency of an isoenzyme of CYP2D6 attracts increase of concentration of active agent in blood (approximately by 7 times). About 77% are brought by kidneys. An elimination half-life — 6 hours. The renal failure and a liver attracts increase in concentration in blood of a tolterodin and its active metabolite twice.

Indications to use

Superactivity of a bladder with frequent insuperable desires, an incontience of urine and increase of an urination.

Contraindications

  • hypersensitivity;
  • closed-angle glaucoma;
  • the imperative desires caused by organic pathology;
  • ischuria;
  • myasthenia gravis;
  • ulcer colitis;
  • megacolon;
  • the slowed-down gastric emptying;
  • age till 18 flyings;
  • portability of fructose, deficit of invertase-isomaltase.

With care appoint at the expressed obstruction of uric ways, decrease in an intestinal vermicular movement, a pyloric stenosis, a liver / renal failure, hernia of an esophageal opening, neuropathy.

Side effects

The met side reactions are more often:

Dryness in a mouth.

Not often and seldom met side reactions:

  • headache, dizziness;
  • lock, swelling abdominal pain, vomiting;
  • weakness, drowsiness;
  • dryness of scleras;
  • vision disorders;
  • confusion of consciousness;
  • stethalgia, bronchitis, increase in weight, xeroderma (tablets);
  • sinusitis (capsules);
  • ischuria, dysuric phenomena;
  • "inflow" of blood to the person;
  • small tortoiseshell;
  • tachycardia, heart consciousness;
  • fatigue, nervousness;
  • hallucinations;
  • peripheral hypostases.

Detruzitol, application instruction (Way and dosage)

The recommended dose of 4 mg a day.

Pill is taken on 2 mg by 2 times a day, and pass capsules of 4 mg of 1 times irrespective of meal time.

The capsule is swallowed entirely. The dose of drug is reduced to 2 mg a day at individual portability.

Overdose

Overdose is shown by symptoms: accommodation disturbance, expansion of pupils, strong excitement, hallucinations, the complicated urination or its delay, spasms, breath disturbance.

Treatment is begun with a gastric lavage, reception of enterovorbent. Further the symptomatic treatment is carried out: at excitement and hallucinations — Physostigmine; at spasms — benzodiazepines; at tachycardia — reception of beta adrenoblockers; at respiratory insufficiency IVL is carried out; at an ischuria — catheterization.

Interaction

Anticholinergics strengthen effects of a tolterodin and the increased risk of side reactions is noted.

Weakens action of Metoclopramidum and Tsizaprid. M-cholinolytics reduce efficiency of drug.

There is a probability of interaction with drugs which are metabolized by P450, CYP2D6 or CYP3A4 cytochrome.

At insufficiency of an isoenzyme of CYP2D6 you should not appoint Erythromycin and Klaritromitsin, Itrakonazol, Mekonazol, Ketokonazol as increase in concentration of this drug and overdose by it is possible.

Does not interact with Warfarin. There is no interaction with the combined tableted contraceptives.

Terms of sale

According to the recipe.

Storage conditions

At a temperature no more than 25 Pages.

Period of validity

2 years.

Detruzitol's analogs

Roliten, Urotol.

About Detruzitole

It is not enough reviews of drug as an urine incontience subject very delicate and not all about it can tell and share opinions.

The urine incontience at some young women arose after the delivery, followed ruptures of an urinogenital diaphragm or a crotch, as is a cause of infringement of function of finkter of a bladder.

The incontience of urine is noted by women after 60 flyings that is explained by oestrogenic insufficiency at this age. Drug was accepted by patients of different age categories. To women of climacteric age replacement hormonal therapy was in parallel appointed.

Responses confirm high performance and at a bladder hyperactivity — frequent urinations. Detruzitol's use led to decrease in frequency of urinations and simplification of deduction of urine. The dysuric phenomena, episodes of an incontience of urine disappeared and urination volume increased. Some note big efficiency of capsules of the slowed-down release in comparison with a standard form of drug. Dryness in a mouth was noted not by all patients or it was not expressed. It is explained by more selective effect in relation to bladder receptors, than to receptors of sialadens.

Drug was not used at children as safety of use it at this age is not studied.

Detruzitol's price where to buy

Detruzitol cannot buy at the moment. In pharmacy chain of Moscow analogs are offered: tablets Urotol of 2 mg No. 56 which can be bought for 953-1196 rub, and also tablets Roliten of 2 mg No. 30 at the price from 294 rub to 485 rub.

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Education: Graduated from Sverdlovsk medical school (1968 - 1971) as "Paramedic". Graduated from the Donetsk medical institute (1975 - 1981) as "An epidemiologist, a hygienist". Passed postgraduate study in the Central scientific research institute of epidemiology Moscow (1986 - 1989). An academic degree – the candidate of medical sciences (degree is awarded in 1989, protection – the Central scientific research institute of epidemiology Moscow). Numerous advanced training courses are studied in epidemiology and infectious diseases.

Experience: Work as the manager of department of disinfection and sterilization of 1981 - 1992. Work as the manager of department of especially dangerous infections of 1992 - 2010. Teaching activity at Medical institute 2010 - 2013.