Диаформин Drug photo

The description is actual on 01.02.2016

  • Latin name: Diaformin
  • ATH code: A10BA02
  • Active ingredient: Metforminum (Metformin)
  • Producer: "Farmak", Kiev, Ukraine


Each tablet contains 500, 850 or 1000 mg of active ingredient, Metforminum hydrochloride, and also excipients in small kolichesva: starch from potatoes, microcrystallic cellulose, povidone, magnesium stearate and polyethyleneglycol.

Release form

Is issued in the form of tablets with various content of active ingredient: Diaformin 500 (500 mg of Metforminum), Diaformin 850 (850 mg) and Diaformin 1000 (1000 mg).

Place 10 tablets in the blister. Blisters are put in a cardboard pack on 3 or 6 pieces.

Pharmacological action

Treats hypoglycemic means for oral administration. Lowers concentration of glucose in blood, but does not influence insulin secretion therefore it is not capable to cause a hypoglycemia in the healthy person.

Pharmacodynamics and pharmacokinetics


Diaformin influences exchange processes of a human body in several ways. After administration of drug:

  • sensitivity of receptors to hormone to insulin increases;
  • cellular utilization of glucose increases;
  • intensity of a hepatic gluconeogenesis changes;
  • in a digestive tract carbohydrates are less intensively absorbed;
  • speed of a lipidic exchange increases, at the same time such indicators as LPNP, TG and cholesterol decrease.


From the very first reception of tablets active ingredient is well absorbed by a digestive tract. At the same time its bioavailability is equal to 50-60%. But at a concomitant use with food absorption decreases and happens much more slowly.

Having got to an organism, substance partially collects in fabrics and partially in not changed look is removed with urine and a stake. The elimination half-life from an organism lasts 9-12 hours. But if functions of kidneys are broken, it lasts longer. In this case there is a risk that drug will collect in an organism and will cause overdose.

Indications to use

Diaformin is shown at:

  • non-insulin-dependent diabetes at adults when it is burdened by obesity and the dietotherapy was low effective.
  • achrestic diabetes (Diaformin's reception and insulin is combined). Diaformin's use is especially shown to patients at a gross obesity when secondary resistance to insulin drugs is observed.


Drug is forbidden to be accepted at:

  • to diabetic coma or precoma;
  • diabetic ketoacidosis;
  • disturbance of filtrational ability of kidneys;
  • existence in an organism of processes and pathologies at which there is a risk of heavy disturbances in work of kidneys;
  • dehydration;
  • to severe fever;
  • sepsis;
  • shock;
  • severe forms of infectious diseases;
  • heart and respiratory failure;
  • acute myocardial infarction;
  • liver dysfunctions;
  • alcoholism;
  • poisoning with alcohol;
  • existence of a lactacidemia in the anamnesis;
  • organism exhaustion (because of a low-calorie diet, big exercise stresses at advanced age);
  • recently undergone operation;
  • pregnancies.

Side effects

During treatment undesirable reaction to drug from various systems of a human body can appear.

From the alimentary system:

  • smack of metal in a mouth;
  • nausea and vomiting;
  • lack of appetite;
  • dispepsichesky frustration;
  • painful feelings in a stomach;
  • meteorism.

To eliminate or reduce these symptoms it is possible to accept a spasmolysant or one of drugs of atropine and to begin to drink tablets after food 2 or 3 times in a day. If these measures did not give relief, Diaformin's reception is cancelled.

From exchange processes:

  • lactic diathesis is a direct indication to urgent drug withdrawal;
  • B12 hypovitaminosis (only at long drug intake).

Also the allergy in the form of an itch and rash on skin can develop. Undesirable reaction from the hemopoietic system is very seldom observed – development of megaloblastny anemia.

Diaformin, application instruction

Only the doctor to each patient individually has to select a dosage and duration of therapy. At the same time disease severity and level of glucose in blood is considered.

It is necessary to begin treatment with a daily dose of 500-1000 mg. It is possible to raise a dosage only in 10-15 days, considering at the same time an analysis indicator on glucose level in blood. Usually at a maintenance therapy take 1500-2000 mg medicine in a day. The most admissible daily dose is equal to 3000 mg.

To children of 10 years drug can be appointed with an initial dose in 500 or 850 ml a day. At most, to which it is possible to raise a dose, – 2000 mg/days, at the same time divide a dose into 2 or 3 receptions.

Swallow of a tablet, without chewing. It is done during food or after it. For decrease in probability of development of undesirable effects from a stomach and intestines, it is desirable to break a daily dose into several receptions.


At overdose the lactacidemia develops. It can be distinguished on such signs:

  • diarrhea;
  • feeling of nausea;
  • vomiting;
  • high temperature of a body;
  • painful feelings in muscles;
  • abdominal pain;
  • disturbance of breath in the form of an asthma;
  • dizziness which can lead to a loss of consciousness;
  • coma (at a heavy lactacidemia).

As soon as there were first signs of a lactacidemia, it is necessary to stop urgently drug intake and to take the victim to hospital. It is possible to give symptomatic help. In hospital to the patient have to make a hemodialysis to bring a medicine out of an organism.


It is necessary to be very careful appointing drug to the person who accepts some other drug as some combinations can strongly be reflected in a condition of an organism of the patient in the same time:

  • The combination with dinazoly is capable to provoke effect of a hyperglycemia.
  • Simultaneous use with means on the basis of alcohol can promote development of a lactacidemia. At exhaustion of an organism or diseases of a liver such combination is categorically contraindicated.
  • GKS increases sensitivity to glucose and its concentration in plasma. In this case it will be necessary to pick up an individual dosage of Diaformin.
  • At treatment by antipsychotic medicines and Diamorphine it is regularly necessary to check glucose level in blood and to adjust a dose.
  • Reception together with diuretics and kaliysberegayushchy drugs can lead to a renal failure that will cause a lactacidemia. Combination is allowed only on condition of careful control of clearance of creatinine. If it becomes lower than 60 ml in a minute, it is contraindicated to drink Diaformin.
  • Considerably reduce effect of medicine β2-симпатомиметики. It is possible to correct a situation having added an insulin therapy to treatment.
  • Sulfanylurea, insulin, salicylates and other drugs which also reduce glucose level in blood at a concomitant use with Diaformin can lead to a hypoglycemia.
  • The drug Nifedipine promotes strengthening of absorption of Metforminum and increases its average maximum concentration.

Terms of sale

Only according to recipe.

Storage conditions

The place where drug is stored, has to be protected from beams of the sun and unavailable to children. Storage is admissible at the room temperature.

Period of validity

3 years.

Special instructions

Irrespective of whether is at the patient of a disease of kidneys, during treatment by Diaformin it is necessary to determine at least two times a year lactate level. Same it is necessary to do if morbidity in muscles appears.

If during treatment it is necessary to pass radio isotope or X-ray inspection at which will be contrast on the basis of iodine drugs is entered, it is necessary to stop drug intake in two days prior to diagnostic procedure. In two days after it therapy can be continued.

To children

There are not enough researches to draw a conclusion on safety and efficiency of drug in treatment of children therefore till 10 flyings it is not appointed.

Coincidence on the ATH code of the 4th level:

Treat analogs:

About Diaformin

Generally About Diaformin positive. Medicine helps to lower and control the level of sugar and at the same time costs rather not much.

Diaformin's price where to buy

Diaformin can buy in a usual drugstore, but it is better to specify existence in advance. Tablets cost from 60 rubles (in packaging of 30 tablets on 500 mg) to 300 rubles (in packaging of 60 tablets on 1000 mg).

The cost of tablets in Ukraine fluctuates from 50 hryvnias (30 pieces on 500 mg) to 180 hryvnias (60 pieces on 1000 mg).


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Section: Diabetic
PAY ATTENTION! Information on drugs on the website is help generalizing, collected from public sources and can form the basis for making decision on use of medicines it is not aware of treatment. Before medicine use Diaformin surely consult with the attending physician.