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Contains in 1 dragee mg diazepam 2 or 5, as excipients: monohydrate of lactose, potato starch, calcium stearate.
1 ampoule contains 2 ml of solution, the content of substance diazepam — 10 mg.
- in a cardboard box in the blister containing 24 tablets;
- ampoules release in blisters on 5 pieces — in one box 2 blisters.
Tranquilizing, myorelaxation (weakening skeletal muscles), gipnosedativny and anksiolitichesky action.
Pharmacodynamics and pharmacokinetics
Diazepam is a tranquilizer of a benzodiazepine row which is capable to exponentiate the central action γ - aminobutyric acid as the main brake mediator of TsNS, creating a component of supramolecular unit – a receptor complex бензодиазепин-γ-аминомаслянной acids – the chlorionophore which is placed on membranes of neurons. It possesses selective stimulation of effect of γ-aminobutyric acid of acid in a reticular formation of a brainstem that reduces excitement of a cerebral cortex, limbic system, a thalamus and hypothalamus. The myorelaxation effect is implemented on the brake mechanism of action on polisinaptichesky reflexes of a muscular tension.
Diazepam is characterized by dozozavisimy influence on TsNS: small doses (to 15 mg a day) render the stimulating effect while high (it is more than 15 mg) – sedative.
As for pharmacokinetics, oral administration causes absorption of 75% of a dose in a digestive tract, about 98% of diazepam contact plasma proteins, development of therapeutic effect happens for 2-7 day of a course of treatment.
The metabolism occurs in a liver where 99% of diazepam are transformed to the inactive and active metabolites capable to get through a gematoplatsentarny barrier and into breast milk. Drug in two phases mainly is excreted by kidneys (70%), to 10% it is removed with a stake. The elimination half-life at the first stage makes 3 hours, on the second – 48 hours.
Indications to use
Appoint at different neurosises, concern and alarm, a psychopathy, schizophrenia, sleeplessness and other sleep disorders, epilepsy, an abstinence syndrome at an alcoholism, a spastic state and a pruritic dermatosis, and also at miozita, a bursitis, arthritises which are followed by tension of skeletal muscles.
Hypersensitivity to the making components of Diazepam and other benzodiazepines, and also at a liver and renal failure, the myasthenia expressed to a chronic hypercapnia, closed-angle glaucoma and during pregnancy.
Diazepam can cause the following side effects:
- slowness of reactions;
- oppression of a mental and physical activity;
- muscular weakness or ataxy;
- dryness in a mouth;
- dyspepsia (disturbance of normal functioning of a stomach);
- dispnoe (asthma);
- urine incontience;
- galactorrhoea (pathological spontaneous secreting by mammary glands and milk expiration);
- increase or decrease in a libido;
- allergic reactions.
Prolonged use can develop medicinal dependence, and also memory disturbance.
Diazepam, application instruction (Way and dosage)
Adults accept Diazepam in/in, in oil, rektalno (in) from 4 to 15 mg a day in two steps, at the same time the maximum daily dose can make no more than 60 mg and only in the conditions of a hospital.
To babies and children 6 months are more senior it is possible to take in a dose 0,1–0,8 mg on weight kg a day for 3–4 receptions.
The application instruction of Diazepam assumes intramuscular or intravenous administration on 10–20 mg multiple to the corresponding indications.
The single dose, frequency and duration of a course have to be established individually. Duration of a course has to be as little as possible, for example, treatment of sleeplessness should not exceed weeks, a condition of alarm — 8-12 weeks, assuming the periods of a gradual dose decline.
There is a specific antidote — Flumazenil who on the mechanism is an antagonist of benzodiazepines.
Treatment: gastric lavage, enterosorbentny means, artificial ventilation of the lungs.
At simultaneous use with:
- Neuroleptics, sedative, hypnagogues, opioid analgetics — Diazepam strengthens oppression of TsNS, respiratory center and causes the expressed arterial hypotension.
- Tricyclic antidepressants (including Amitriptyline) — increase of the oppressing effect on TsNS and cholinergic action, increase in concentration of antidepressants is possible.
- Muscle relaxants — their action amplifies, however, the risk of development of an apnoea increases.
- Oral contraceptives effects of Diazepam can amplify, increasing risk of development of bleeding of breakthrough type.
- Bupivacaine, fluvoksaminy — increase of its concentration in a blood plasma is possible.
- Diclofenac — strengthening of dizziness.
- Isoniazid, Paracetamol — decrease in removal of Diazepam.
- Carbamazepine, Phenytoinum, Rifampicin, Phenobarbital — removal and a metabolism of Diazepam accelerates.
- Caffeine — reduction sedative and, perhaps, anksiolitichesky effect of Diazepam.
- Clozapine — reactions of the expressed arterial hypotension, respiratory depression, a loss of consciousness are possible.
- Levodopa — suppression of protivoparkinsonovy action.
- Lity the carbonate — recorded a case of development of a coma.
- Metoprolol — decrease in sight and deterioration in psychomotor reactions is possible.
- Theophylline in small doses — a perversion of sedative effect of Diazepam.
- Cimetidinum, Omeprazol, Disulfiramum — increase in duration of effect of Diazepam.
- Ethanol — etanolsoderzhashchy drugs strengthen oppression of TsNS, generally influence on a respiratory center, emergence of a syndrome of pathological intoxication is possible.
Terms of sale
In the presence of the recipe.
In the dry, protected from rays of light place, with ambient temperature 15–25 ° Celsius.
Period of validity
During treatment by Diazepam alcohol intake is inadmissible.
Concerning driving by motor transport and controls of mechanisms – danger exists as drug can cause dizziness, hallucinations or the general delay of speed of a psychomotor system.
Coincidence on the ATH code of the 4th level:
Considering that independent administration of drug is categorically inadmissible, especially — in children's practice, About Diazepam are generally positive, and note its efficiency though many are disturbed by a big number of side effects and accustoming, and also rather difficult withdrawal.
The Diazepam price where to buy
The Diazepam price for 5 mg (20 pieces) makes 620 rubles. It is possible to buy Diazepam in Moscow, in advance having ordered in Internet drugstores, delivery with the courier — 500 rubles within MKAD without order cost within 2 hours.
Section: For a nervous system
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