Дифлюзол Drug photo

The description is actual on 13.10.2014

  • Latin name: Difluzol
  • ATH code: J02AC01
  • Active ingredient: Flukonazol (Fluconazole)
  • Producer: JSC Kiyevmedpreparat (Ukraine)


One capsule of Difluzol contains active agent of a flukonazol –50, 100 or 150 mg. Other substances: calcium stearate, krakhmalglikolit sodium.

Release form

Drug is let out in the form of capsules for intake. Packaging contains 7 capsules (on 0,05 g or on 0,1 g) or 1 capsule (0,15 g).

Pharmacological action

Difluzol is the anti-mycotic medicine applied to treatment of fungal infections. The mechanism of action of a medicine consists in disturbance of biosynthesis of the sterol which are a part of a cell wall of mushrooms that leads to their death. Drug is used also in gynecologic practice. The expressed antifungal effect of drug allows to apply Difluzol from the milkwoman.

Pharmacodynamics and pharmacokinetics

Active component flukonazol on the structure belongs to the new class of drugs – triazolny connections and is applied as an antimycotic (anti-fungal) broad-spectrum agent. Difluzol shows the activity concerning the majority of fungal activators. Drug resistance forms slowly.

Indications to use

Drug is appointed at fungal infections:

  • cryptococcosis (for example, cryptococcal meningitis);
  • genital candidiasis;
  • the disseminated candidiasis;
  • mycosis of skin of a trunk, feet, inguinal area;
  • bronchopulmonary candidiasis;
  • kandiduriya;
  • fungal balanitis;
  • oral cavity candidiasis (atrophic form) against carrying dentures;
  • chromophytosis;
  • local deep mycosis;
  • onychomycosis.

Medicine can be appointed also with the preventive purpose, in particular, to the oncological patients receiving radiation therapy or accepting immunosuppressor medicines and cytostatics.


Drug is not appointed at individual hypersensitivity to its components. Do not recommend to appoint drug to children till 6 flyings.

Side effects

Nervous system:

Digestive tract:

System of a hemopoiesis:

  • neutropenia;
  • agranulocytosis (oppression of a leukopoiesis);
  • thrombocytopenia.

Seldom are registered:

The allergic answer in the form of a face edema, an itch, an acute anaphylaxis, the small tortoiseshell is possible. Lengthening of the period of QT on the electrocardiogram against treatment can be a harbinger of arrhythmias.

The instruction on Difluzol (A route of administration and dosages)

The daily dose of a medicine is defined individually and depends on weight and the nature of mycosis. At treatment of candidiases mucous an organism appoint 50-100 mg of times at 24 o'clock, a course of reception of Difluzol from 14 to 30 days.
In the first days of treatment of cryptococcoses register 400 mg of drug, in the next days on 200-400 mg.
The period of treatment of meningitis, depending on a form and efficiency of therapy, lasts 6-8 weeks.
Standard schemes of treatment of mycoses: on 50 mg in each 24 hours or 150 mg a week. A course of reception of a medicine about six weeks.

Therapy of a chromophytosis consists in weekly reception of a medicine in a dose of 0,3 g or daily reception of 0,05 g, duration of treatment from 2 to 6 weeks. To people of old age in the absence of absolute contraindications flukonazol appoint according to the standard scheme.

The instruction on Difluzol for children. In pediatric practice at fungal pathology mucous the dose of a medicine is calculated according to the scheme: 3 mg of a flukonazol on 1 kg. At treatment of candidiasis or a cryptococcus – from 6 to 12 mg/kg. At treatment of children of two weeks of life the dose is appointed taking into account the low speed of removal of active component, an interval between receptions – 72 hours. For monthly children the interval between receptions makes 48 hours.

In gynecologic practice the medicine is appointed at the milkwoman. Use of traditional means (a candle, cream) causes the mass of inconveniences. Therefore today even more often use capsules for intake.
How to accept at the milkwoman: on 0,05-0,1 g each 24 hours, the course is expected 2-4 weeks. Capsules accept inside, washing down with water. The food does not affect efficiency of a medicine.


Reception of the raised doses of Difluzol leads to development of hallucinations, paranoid behavior. The artificial diuresis, posindromny therapy, a hemodialysis and a gastric lavage allow to reduce poisoning symptomatology.


Difluzol strengthens action of anticoagulating means, hypoglycemic medicines, Hydrochlorthiazidum, Difenin. At combined use to Rifampicin there is a reduction of an elimination half-life of Difluzol. At one-time reception with Cyclosporine, Tsidovudin increase in blood of their concentration is probable. Antacids, Cimetidinum and food do not exert impact on Difluzol absorption.

Terms of sale

Difluzol is means of non-prescription dispensing.

Storage conditions

To protect capsules from children. The recommended temperature range: 15-25 degrees.

Period of validity

At observance of the mode of storage flukonazol it is suitable within four years.

Special instructions

At registration of the raised indicators of ALT, nuclear heating plant and bilirubin it is recommended to estimate expediency of the carried-out therapy. At emergence of skin rashes the medicine is cancelled. At immunodeficiency and at pathology of hepatic system flukonazol appoint with care, estimating effects. Difluzol does not exert impact on efficiency of contraceptive medicines.

Analogs of Difluzol (substitutes)

Structural analogs: Mikosist, Flucostat, Diflucan, Flukozan, Flukozid, Maykonil, Diflazon, Medoflyukon, Nofung, Mikomaks, Mikoflyukan, Flukonazol, Fungolon, Tsiskan, Flukomitsid, Flukoral, Flukonorm, Flyukor, Forkan, Futsis, Flyuzak.


  • Capsule difluzol 0.05g No. 7kiyevmedpreparat (Ukraine, Kiev)
  • Difluzol
  • Capsule difluzol 0.15g No. 1kiyevmedpreparat (Ukraine, Kiev)
  • Capsule difluzol 0.15g No. 2kiyevmedpreparat (Ukraine, Kiev)
  • Capsule difluzol 0.1g No. 7kiyevmedpreparat (Ukraine, Kiev)


  • Difluzol kaps. 0.05g No. 7kiyevmedpreparat
  • Difluzol kaps. 0.05g No. 7kiyevmedpreparat
  • Difluzol kaps. 0.05g No. 7kiyevmedpreparat
  • Difluzol kaps. 0.05g No. 7kiyevmedpreparat


  • Difluzol of 150 mg No. 1 kaps. Kiyevmedpreparat of joint stock company (Ukraine)
  • Difluzol of 50 mg No. 7 kaps. Kiyevmedpreparat of joint stock company (Ukraine)
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Section: Gynecologic Antifungal
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Education: Graduated from the Bashkir state medical university majoring in "Medical business". In 2011 gained the diploma and the certificate in Therapy. In 2012 received 2 certificate and the diploma in "Functional diagnosis" and "Cardiology". In 2013 completed courses on "Topical issues of otorhinolaryngology in therapy". In 2014 completed advanced training courses in "A clinical echocardiography" and courses in "Medical rehabilitation".

Experience: From 2011 to 2014 the Policlinic No. 33 Ufa worked as the therapist and the cardiologist in MBUZ. Since 2014 the Policlinic No. 33 Ufa works as the cardiologist and the doctor of functional diagnosis in MBUZ.

PAY ATTENTION! Information on drugs on the website is help generalizing, collected from public sources and can form the basis for making decision on use of medicines it is not aware of treatment. Before medicine use Difluzol surely consult with the attending physician.