Диклоран Drug photo

The description is actual on 29.06.2016

  • Latin name: Dicloran
  • ATH code: M02AA15
  • Active ingredient: Diclofenac (Diclophenacum)
  • Producer: J.B.Chemicals & Pharmaceuticals Ltd.) (India)


Solution for injections — sodium diclofenac, benzyl alcohol, Mannitolum, propylene glycol, sodium hydroxide, sodium metabisulphite, water sterile.

Gel for external use — diethyl amine diclofenac, methyl salicylate, oil of seeds of flax, left menthol, butylhydroxyanisole, benzyl alcohol, butyl hydroxytoluene, carbomer, citric acid, dinatrium edetat, a macrogoal, glitserilgidroksistearat, propylene glycol, water.

Tablets enterosoluble — sodium diclofenac, corn starch, talc, lactose, magnesium stearate, anhydrous silicon dioxide, sodium of a kroskarmeloz, dye yellow, polyethyleneglycol, methacrylic acid, titanium dioxide.

Release form

  • Tablets enterosoluble 50 mg in planimetric packaging in a cardboard pack No. 20.
  • Gel in an aluminum tuba on 20 g, in a cardboard pachke.kkkkkkkk
  • Solution in glass ampoules on 3 ml in cardboard packaging to No. 5 or 25.

Pharmacological action

Antiinflammatory, analgeziruyushchy, febrifugal, anti-aggregation.

Pharmacodynamics and pharmacokinetics


Treats NPVS, has the expressed analgeziruyushchy, antiinflammatory and moderate febrifugal effect. The mechanism of action is based on oppression of activity of a metabolism of arachidonic acid (TsOG enzyme) — the predecessor of prostaglandins playing the leading role in development of process of an inflammation, fever of a pain syndrome. The anesthetizing action is caused by the peripheral mechanism (indirectly, through process of suppression of production of prostaglandins) and central (as a result of stopping of process of synthesis of TsNS prostaglandins and a peripheral nervous system).

At rheumatic diseases reduces morbidity in joints at the movement and at rest, a swelling of joints and morning constraint, increases the volume of joint movements. Reduces postoperative and posttraumatic inflammatory hypostasis and a pain syndrome.

At a long course of treatment has the desensibilizing effect, reduces aggregation of thrombocytes, inhibits production of proteoglycan in cartilages.


Tablets at intake it is quickly absorbed from a gastrointestinal tract, at the same time, the food slows down absorption speed, but extent of absorption does not change. Cmax time in blood after reception of tablets — 2-4 hours. It is metabolized in a liver with formation of several metabolites, does not kumulirut. Communication with blood proteins (with albumine) high (99.7%). Gets into synovial fluid. An elimination half-life from blood — 1-2 hours. About 60% of a dose are removed by kidneys in the form of metabolites, other part — in the form of metabolites with bile.

At external use of drug in the form of gel the sodium diclofenac, linseed oil and methyl salicylate which are its part are quickly soaked up and well get into hypodermic cellulose, muscles and a capsule of a joint.

Indications to use

  • Diseases of a musculoskeletal system of inflammatory genesis, including with existence of degenerative changes (an osteoarthrosis, the pseudorheumatism ankylosing a spondylitis, a spondylarthrosis, spondylarthrites);
  • gouty arthritis in an acute stage;
  • rheumatic defeats of soft extraarticular tissues (bursitis, mialgiya, tendovaginitis);
  • sciatica, lumbago, backbone pain, radiculitis;
  • neuralgia, inflammation and pain syndrome at injuries and after operative measures.


High sensitivity to drug, the rhinitis, urticaria, a bronchospasm caused by use in the anamnesis of NPVS; an exacerbation of diseases of a gastrointestinal tract with existence of erosive and ulcer processes; age till 18 flyings, the period of pregnancy and a lactation, disturbance of a homeostasis and a hemopoiesis.

Side effects

  • nausea, gastropathy, heartburn, meteorism, eructation, discomfort in a stomach;
  • dizziness, headache, fast fatigue;
  • irritability, sonitus, sleep disorder, memories, spasms, depression, feeling of alarm, drowsiness, disorientation, tremor, nightmares, aseptic meningitis, mental disturbances;
  • itch and dermahemia, rashes;
  • liquid delay, dysmenorrhea;
  • peripheral hypostases;
  • hamaturia, depression of function of kidneys, intersticial nephrite;
  • agranulocytosis, thrombocytopenia, leukopenia, anemia hemolitic, aplastic;
  • arterial hypertension;
  • heartbeat, cardialgias, stethalgia;
  • allergic reactions.

Dikloran, application instruction (Way and dosage)

Tablets — to accept inside, without chewing at meal. A single dose for adult 25-50 mg 2-3 times a day depending on a type of a disease and weight of a current. The maximum daily dose at intake — 150 mg/days. After achievement of medical effect accept the supporting daily dose – 50 mg.

Solution for injections — is used only for intramuscular introduction. The drug needs to be administered deeply in a gluteus, the adult in a dose of 75 mg (1 ampoule) once a day. Duration of intramuscular introduction no more than two weeks, and then it is necessary to pass to the tableted drug form. In exceptional hard cases introduction of 75 mg twice a day is allowed (in each buttock on 1 injection), but, at the same time, the interval between introduction has to be more than two hours. If necessary combine injections with tablets (to 150 mg a day).

Gel for external use — to rub in the struck zone (a painful site) in a dose 2-4 grams 3-4 times a day. Duration of rubbing in should not exceed 10 days. In the absence of effect consultation of the doctor is necessary.


Headache, dizziness, opacification of consciousness, nausea, vomiting, myoclonic spasms, bleedings, stomach ache, renal failure, respiratory depression.


It is not necessary to combine Dikloran's reception with other NPVP (pyrazyl ketones and salicylates) as strengthening of toxicity and decrease in efficiency of drug is possible. The concomitant use with anticoagulants increases risk of bleedings. Dikloran's toxicity increases at the combined reception with glucocorticosteroids.

At a concomitant use of drug with antibiotics of a tsiklosporinovy row and paracetamol the nephrotoxic effect increases. At joint appointment with metal salts in a blood plasma, concentration of ions of lithium increases. Acetylsalicylic acid lowers concentration of drug in blood. The concomitant use with ethanol, corticotropin, drugs of a St. John's Wort and colchicine increases probability of bleedings in a gastrointestinal tract.

Dikloran reduces efficiency of hypnotic drugs and antihypertensives. Dikloran causes a delay in an organism of water and sodium, the therapeutic effect of diuretics decreases.

Terms of sale

According to the recipe.

Storage conditions

At a temperature no more than 25 °C.

Period of validity

3 years.

Dikloran's analogs

Voltarenum, Voltarenum Retard, Diklak, Diklobene, Dikloberl, Decalogue, Diklonak, Diklotard, Diclofenac, Naklofen, Nergez, Ortophenum, Evinopon and others.

About Diklorana

According to numerous responses Dikloran's use finds broad application in practice of treatment of diseases of a musculoskeletal system. Gel Dikloran who many visitors of forums call "ointment Dikloran" is especially often used. Efficiency of drug rather high also allows to stop an inflammation and pain.

  • "… I use pricks Dikloran practically always at exacerbations of osteochondrosis and shoulder joint pains. Helps well. Especially in an initial stage".

However, many patients complain of quickly arising stomach aches. In such cases Omez is better to accept in parallel.


  • Dikloran plus gel 30gunique Pharmaceutical Lab.

Drugstore of IFC

  • Dikloran Plus gel 30 of, Unique Pharmaceuticalindiya
to show still


  • Dikloran plus gel of 1% 30gyunik (India)


  • Dikloran plus gel of 1% 30 g.


  • Dikloran Plus of 30 g gel in a tubeyunik of Pharmaceutical Laboratoriz (India)
to show still
Section: For joints Anesthetics
in more detail

Education: Graduated from Sverdlovsk medical school (1968 - 1971) as "Paramedic". Graduated from the Donetsk medical institute (1975 - 1981) as "An epidemiologist, a hygienist". Passed postgraduate study in the Central scientific research institute of epidemiology Moscow (1986 - 1989). An academic degree – the candidate of medical sciences (degree is awarded in 1989, protection – the Central scientific research institute of epidemiology Moscow). Numerous advanced training courses are studied in epidemiology and infectious diseases.

Experience: Work as the manager of department of disinfection and sterilization of 1981 - 1992. Work as the manager of department of especially dangerous infections of 1992 - 2010. Teaching activity at Medical institute 2010 - 2013.

PAY ATTENTION! Information on drugs on the website is help generalizing, collected from public sources and can form the basis for making decision on use of medicines it is not aware of treatment. Before medicine use Dikloran surely consult with the attending physician.