Dobutaminum

Добутамин Drug photo

The description is actual on 25.09.2015

  • Latin name: Dobutamin
  • ATH code: C01CA07
  • Active ingredient: Dobutaminum
  • Producer: Wasserburger Arzneimittelwerk Dr. Madaus GmbH & Co.KG (Germany), Solvay Pharmaceuticals (Germany), Haupt Pharma Wulfing GmbH (Germany), Grindeks (Latvia), Russian cardiological scientific-industrial complex of Medresurs (Russia)

Structure

In 1 bottle of Dobutaminum of a hydrochloride of 280 mg.

Excipient Mannitolum.

Release form

  • Lyophilisate of 250 mg for solution preparation.
  • Solution for infusions of 250 mg.
  • Concentrate for preparation of solution in ampoules on 10 ml.

Pharmacological action

Cardiotonic.

Pharmacodynamics and pharmacokinetics

Pharmacodynamics

Dobutaminum — a synthetic catecholamine, β1-адреномиметик. Stimulating β1-адренорецепторы a myocardium, increases sokratitelny ability of a myocardium. Increases shock and minute volumes of heart, reduces OPS of vessels. Causes moderate increase in heart rate. Positive dromotropic (increase in conductivity) and chronotropic action is shown when using high doses.

In average doses it poorly influences the ABP. As at drug the short elimination half-life it is entered continuously. If continuous therapy lasts 72 h and more, accustoming develops. Dobutaminum is applied, controlling an ECG, the ABP and ChSS.

Pharmacokinetics

After intravenous administration the effect is noted in 1–2 min., steady concentration in blood is noted in 10-15 min. Elimination half-life of 2-4 min.

Indications to use

  • fluid lungs;
  • acute heart failure;
  • HSN decompensation (as temporary supportive application);
  • carrying out a stress echocardiography with the diagnostic purpose;
  • low minute volume of heart.

Contraindications

  • hypovolemia;
  • mechanical obstacle (the expressed aorta stenosis, cardiac tamponade, subaortic stenosis) to filling or outflow of blood from heart ventricles;
  • hypersensitivity to active ingredient;
  • reception of MAO inhibitors.

Side effects

  • stenocardia attacks;
  • tachycardia, heartbeat;
  • skin itch, rash;
  • disturbance of a cordial rhythm (ekstrasistoliya, fibrillation of ventricles);
  • bronchospasm;
  • phlebitis in an injection site;
  • increase of the systolic ABP;
  • nausea, fever, headache.

All reactions from CCC depend on a dose and disappear at reduction in the rate of introduction or after the infusion termination.

Dobutaminum, application instruction (Way and dosage)

Dobutaminum Geksal as well as his analogs of other producers, is intended only for intravenous administration in a divorced look (with solutions of 5% of glucose, Ringera, chloride sodium). Divorced solution is stored by no more than 24 h. Speed and duration of introduction depends on hemodynamic indicators therefore constantly control ChSS, the size ABP, whenever possible minute volume of heart. The adult usually enter 2,5-10 mkg/kg/min. in a dose, it is very rare — 40 mkg/kg/min. To children — 1 - 15 mkg/kg/min.

Overdose

It is shown by symptomatology: tachycardia, stenocardia attacks, arrhythmia. These reactions disappear upon termination of infusion/reduction in the rate of infusion.

Interaction

Reception β - adrenoblockers weakens effect of drug, at the same time its alpha effects can prevail that will lead to vasoconstriction and increase of the ABP.

Venous vazodilatator (Sodium nitroprussidum, nitrates) applied together with Dobutaminum will even more increase minute heart volume, will reduce peripheric resistance.

 Drug causes the increased need for insulin in patients with a diabetes mellitus.
Reception with APF inhibitors attracts increase in minute volume that increases need of a myocardium for oxygen and there are the reason of anginous pains and disturbances of a rhythm.

The combination Dobutaminumthe Dopamine causes substantial increase of the ABP and decrease in filling of ventricles.

It is contraindicated to accept MAO inhibitors from - for risk of hypertensive crisis, hemorrhage in a brain and disturbances of a heart rhythm.

Terms of sale

According to the recipe.

Storage conditions

At a temperature no more than 25 °C.

Period of validity

3 years.

Analogs

Coincidence on the ATH code of the 4th level:

Dobuzhekt, Giulini's Dobutaminum (Geksal, Solvey, Nikomed, Lakhem), Dobutreks.

About Dobutaminum

There are no reviews of patients of drug as inotropic means are applied in urgent situations — acute heart failure when sokratitelny function of a left ventricle decreases and cardiac index falls. Such state is observed at septic shock, a cardiomyopathy, at open heart operations and a myocardial infarction. This drug is fundamentals of pharmacotherapy of cardiogenic shock and is not applied to treatment of chronic SN.

Considering that drug can cause tachycardia and arrhythmias, it is applied incontinuously and only in hard cases — at increase of heart failure. It has a small range between medical doses and toxic influence. Unlike the Dopamine does not cause vasodilatation.

Zdravzona

  • Dobutaminum Hexolum of 250 mg of a time. No. 1 fl.
  • Dobutaminum of 250 mg 50 ml No. 1 of amp.
to show still

Apteka24

  • Amide Dobutaminum solution for infusions of 250 mg of an ampoule 50mlameda Farm (India)
Section: Cardiological
in more detail

Education: Graduated from Sverdlovsk medical school (1968 - 1971) as "Paramedic". Graduated from the Donetsk medical institute (1975 - 1981) as "An epidemiologist, a hygienist". Passed postgraduate study in the Central scientific research institute of epidemiology Moscow (1986 - 1989). An academic degree – the candidate of medical sciences (degree is awarded in 1989, protection – the Central scientific research institute of epidemiology Moscow). Numerous advanced training courses are studied in epidemiology and infectious diseases.

Experience: Work as the manager of department of disinfection and sterilization of 1981 - 1992. Work as the manager of department of especially dangerous infections of 1992 - 2010. Teaching activity at Medical institute 2010 - 2013.

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