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In structure Jes Plus (active tablets) the operating ingredients drospirenon, ethinylestradiol betadeks a clathrate, calcium levomefolat contain.
Additional components monohydrate of lactose, croscarmellose sodium, magnesium stearate, a hypro rod also are a part.
As a part of an auxiliary tablet the operating calcium component levomefolat, and also additional ingredients of lactose monohydrate, croscarmellose sodium, a hypro rod, magnesium stearate contains.
Is issued in the form of tablets. Active tablets have the biconvex, round form, they are covered by a pink film cover. On the one hand tablets are an engraving of "Z+" in a hexagon.
Auxiliary tablets have the biconvex, round form, they are covered by an orange film cover. On the one hand tablets are an engraving "M +" in a hexagon.
Planimetric packaging contains about 24 active tablets and 4 more auxiliary tablets. In a cardboard box – one blister.
Tablets Jes Plus are low-dosed peroral monophase is oestrogenic-gestagennym a contraceptive which includes active tablets, and also tablets additional as a part of which is calcium levomefolat.
Contraceptive influence of means is reached thanks to suppression of an ovulation and increase in level of viscosity of cervical slime.
Women who accept such drugs, note that their menstrual cycle gradually becomes more regular, and in days of periods morbidity and intensity of allocations decreases. As a result, at administration of drug at women the risk of development of deficit of iron and anemia decreases. Also there is information that means reduces risk of cancer of an endometria and ovaries.
Substance drospirenon which contains in structure of this contraceptive, exerts antimineralokortikoidny impact on an organism, warns a liquid delay in an organism, coherent with a gormonozavisimost. Also substance provides anti-androgenic with activity what, in turn, provides reduction of display of an acne, improvement of a condition of hair and integuments.
Influence of a drospirenon is similar to influence of progesterone which is naturally produced in the woman's organism. This moment should be considered that who chooses to himself a contraceptive.
Calcium substance levomefolat is biologically active form of folate. This component in an organism is acquired more actively, than folic acid. At regular reception of a levomefolat the need for foliata for a female organism is satisfied.
In the presence as a part of an oral contraceptive of calcium of a levomefolat at the woman accepting such drug risk level of manifestation of defect of a neurotubule of a fruit at unexpected pregnancy decreases. At the same time the woman who only learned about pregnancy has to stop reception of tablets Jes Plus at once.
Pharmacokinetics and pharmacodynamics
Drospirenon at intake is very quickly soaked up, at reception once the greatest concentration in blood is noted in 1-2 hours. Level of bioavailability is equal to 76-85%. Meal does not influence bioavailability of means. It is removed in the form of metabolites by kidneys and a gastrointestinal tract.
Ethinylestradiol is completely and quickly soaked up after oral administration. The greatest concentration of drug is reached in 1–2 hours. Its level of bioavailability makes about 60% at oral administration. If food is at the same time eaten, bioavailability of substance goes down for 25%. It is brought out of an organism in the form of metabolites, through gastrointestinal tract kidneys. An elimination half-life – about 24 hours.
Calcium levomefolat it is soaked up in an organism quickly, it joins in a pool of folates. After reception the two-phase pharmacokinetics is noted: the pool with a fast and slow metabolism is observed. It is removed both in not changed look, and in the form of metabolisms through kidneys and the alimentary system.
Indications to use
Contraceptive tablets Jes Plus are shown as a contraceptive to those women at whom the hormonedependent delay of liquid is noted. Also it is used for contraception for women for whom therapy of a moderate form of acne rash is necessary. Jes Plus is shown as a contraceptive for women in whose organism the lack of folates is noted. It is also shown to women with heavy symptoms of PMS.
It is contraindicated to use contraceptive tablets Jes Plus to women at whom such diseases and conditions of an organism are noted:
- intolerance of components of means or hypersensitivity to them;
- thrombosis, thrombembolia (in the anamnesis, during the current period);
- states which precede development of thrombosis (in the anamnesis, during the current period);
- existence of several factors which increase risk of display of thrombosis;
- migraine at which neurologic symptoms are noted;
- diabetes mellitus at which the patient has vascular complications;
- serious illnesses of a liver, including – a liver failure, liver tumors (high-quality or malignant);
- renal failure in acute or in a severe form;
- the malignant tumors connected with a gormonozavisimost and suspicion on development of such educations;
- bleeding from a vagina which reasons are not clear;
- pregnancy and chest feeding;
- the lactose intolerance connected with heredity.
If any of the listed states or diseases are shown already at reception of a contraceptive, it is necessary to stop immediately reception Jes Plus.
With care it is necessary to take this contraceptive pill if at the woman such diseases or states are noted:
- existence of the factors increasing risk of display of a thrombembolia, thrombosis (excess weight, smoking, arterial hypertension, hereditary tendency to thrombosis, migraine, etc.);
- diseases at which development of disturbances of a peripheral blood-groove is possible;
- liver diseases;
- diseases, development or aggravation of which it was noted for the first time during pregnancy or in the course of treatment by sex hormones;
- period after the delivery.
At reception Jes Plus the following side effects can be noted:
- nausea, pain in mammary glands, emergence of periodic bleedings from a genital tract;
- depression, differences of mood.
Such side effects are in rare instances noted:
- reduction of a sexual inclination;
- mnogoformny erythema;
- increase of arterial pressure;
- disturbances of functioning of a liver;
- allergic reactions.
Jes Plus, application instruction (Way and dosage)
If the woman chooses as a contraceptive this, then its correct reception is obligatory.
The instruction on Jes plus provides oral administration of tablets agrees with that order which is specified on packaging of means. The woman has to know accurately how to take a pill: they do not need to be chewed, it is necessary to wash down with a small amount of liquid. It is necessary to try to use tablets approximately in identical time.
Daily, for 28 days, it is necessary to drink on 1 tablet. After packaging comes to the end, it is necessary to open following at once.
It is necessary to begin reception of tablets in the first day of a monthly cycle, that is in the first day of bleeding.
If at the woman diarrhea or vomiting is noted, then drug in connection with such frustration of an organism can be soaked up not completely owing to what additional contraceptive protection during this period is necessary.
After a menopause of a tablet are not applied.
There is no information on overdose Jes Plus. Display of nausea, vomiting and the smearing allocations is in that case possible. Symptomatic therapy is shown in that case. Calcium levomefolat it is well transferred by an organism.
If reception of oral contraceptives and other drugs is at the same time conducted, display of uterine bleedings or decrease in contraceptive influence of tablets is probable.
At simultaneous treatment by drugs which induce microsomal enzymes of a liver growth of clearance of sex hormones is possible.
If the woman accepts medicines which exert impact on microsomal enzymes of a liver, then at this time, and also for 28 days after the termination of such treatment it is necessary to use additional resources of contraception.
During treatment by antibiotics and within one week after their cancellation it is necessary to use additional contraceptives (an exception – Rifampicin, Griseofulvin).
At reception of some drugs efficiency of calcium of a levomefolat can decrease. It is Trimethoprimum, the Methotrexate, Sulfasalazinum, Triamterenum, Hlestiramin, Phenytoinum, Carbamazepine, Primidonum, Phenobarbital, etc.
Folates change pharmacokinetics or a pharmacodynamics of a number of medicines.
Terms of sale
In drugstores Jes Plus is on sale according to the recipe.
Means needs to be stored at a temperature no more than 25 °C. It is necessary to protect tablets from access for children.
Period of validity
It is possible to store 5 years
It is necessary to compare risk level and advantage in the presence of some diseases at the woman who is going to use Jes Plus for the purpose of contraception.
Reception of means can mask existence in an organism of deficit of B12 vitamin.
If there was an admission of a tablet, then for 24 hours of lowering of contraceptive effect is not observed. It is necessary to take a medicine at once after the woman remembers it. Even if at the same time it is necessary to take two pill, the passed tablet cannot be ignored. More than two pill a day cannot be taken.
If the woman passed tablets, and during the use of inactive pills she has no bleeding, it is necessary to carry out the test for pregnancy.
In the course of reception Jes Plus manifestation of bloody allocations is possible. Most often it happens in the first months of reception of means.
Jes Plus does not provide protection against HIV infection and venereal diseases.
Jes Plus does not pay attention to expressiveness of psychomotor reactions.
Analogs Jes Plus
Coincidence on the ATH code of the 4th level:
Analogs of drug Jes Plus are contraceptives Midiana, Jes, Dimia, Yarina having similar effect on the woman's organism. In spite of the fact that influence of all transferred funds is similar, it is desirable that the contraceptive was selected to the woman by the doctor in an individual order.
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PAY ATTENTION! Information on drugs on the website is help generalizing, collected from public sources and can form the basis for making decision on use of medicines it is not aware of treatment. Before medicine use Jes Plus surely consult with the attending physician.