Эфизол Drug photo

The description is actual on 07.12.2015

  • Latin name: Efisol
  • ATH code: R02AA20
  • Active ingredient: Dekvalina chloride + ascorbic acid
  • Producer: Balkanpharma-Dupnitsa AD (Bulgaria)


1 tablet includes 0,25 mg of a dekvalin of chloride and 30 mg of ascorbic acid.

In addition: pectin, monohydrate of glucose, sodium saccharin, vanillin, magnesium stearate, cocoa powder, sucrose, monohydrate of lactose.

Release form

Efizol is issued in the form of tablets for a rassasyvaniye on 20 or 40 pieces in secondary packaging.

Pharmacological action

Antiseptic, antifungal, antibacterial.

Pharmacodynamics and pharmacokinetics

Efizol is the combined medical drug with pronounced antiseptic, antifungal and antibacterial effects of local character which is applied at inflammatory processes of a throat and an oral cavity. Efizol is considered the main action of tablets bacteriostatic, however some sources note also his bactericidal activity in relation to a number of microorganisms, both gram-positive, and gram-negative, including the strains steady against an antibioticotherapia. Efficiency of tablets is shown at an alkaline indicator rn that assumes its salutary influence in an oral cavity.

The antiseptic agent from group of kvinolin a dekvalina chloride is encore - a quarternary kvinolin of local action with bacteriostatic efficiency. Antibacterial influence of a dekvalin is mainly shown in relation to pyogenic (piogenic) microorganisms, and also strains of the bacteria steady against effects of antibiotics (borreliya, streptococci and so forth). Antifungal activity is observed mainly concerning sort mushrooms Candida (Candida albicans), separate types of epidermofit and mushrooms of a version Trikhofiton (Trychophyton). dekvalin does not exert impact on pathogenic mycobacteria.

Antibacterial efficiency of Efizol which is shown thanks to action of a dekvalin is caused by a denaturation of enzymes and proteins of microorganisms by their depolymerization and dissolution. Also important role is played by a cytolysis of a membrane of a bacterial cell, disturbance of its proteinaceous synthesis at the level of ribosomes, an inactivation and the glycolysis of dehydrogenases which in principle is reversible process, but at long interaction with the activator irreversible. A basis of bacteriostatic effects of a dekvalin is its surface-active cationic influence which was more directed to gram-positive microorganisms.

The ascorbic acid which is Efizol's part is characterized by the impact on the processes of recovery and oxidation happening in cells. Promotes increase in amount of the antibacterial specific antitoxins synthesized by an organism and increases functionality of reticuloendothelial system. Reduces cellular membrane permeability, improves structure of a vascular wall of capillaries and limits allergic, inflammatory and exudative reactions.

Resistance of pathogenic bacteriums to Efizol's ingredients develops quite slowly and is observed only at his long reception for 15-20 days. Most rezistentna to Efizol the microorganisms earlier steady against sulfonamide, streptomycin and penicillin, to a lesser extent mushrooms and gram-positive bacteria.

Initial absorption of ingredients of Efizol happens in an oral cavity and further in a gastrointestinal tract. Distribution is carried out by means of diffusion by means of a liver, kidneys and lungs. Removal quite long intestines and kidneys.

Indications to use

Use of tablets of Efizol (for a rassasyvaniye) is shown:

  • for carrying out local antiseptic therapy at inflammatory processes of a throat and an oral cavity, in case of their emergence because of influence of pathogenic activators, sensitive to Efizol's ingredients (including a fibrous, ulcer, catarral ulitis; glossitis; pharyngitis; candidiasis (milkwoman); aphthous stomatitis; laryngitis; tonsillitis;
  • for treatment of infectious pathologies of a throat in severe forms (with parallel use of streptocides and antibiotics);
  • for the purpose of prevention of possible infections during the presurgical and post-operational periods, when carrying out surgical interventions in a throat and an oral cavity.


Efizol's appointment is contraindicated at:

Side effects

As a rule, treatment using Efizol did not lead to forming of heavy by-effects, however some negative medicamentous reactions characteristic of its active ingredients were revealed.

From outside chloride dekvaliniya

Alimentary system:

  • feeling of dryness in an oral cavity;
  • feeling of irritation and/or burning in a throat;
  • nausea/vomiting;
  • development of dysbacteriosis in an oral cavity (in case of long use of high dosages).

Local phenomena:

  • development of expressions and/or necrosis (at abuse and in rare instances).


  • allergic manifestations (seldom or never).

From ascorbic acid

Cardiovascular system:


Nervous system:

Immune system:

Other (at reception of high dosages more than 1000 mg at 24 o'clock):

  • disturbance of operation of the insulyarny device (including development of a glucosuria and hyperglycemia);
  • disorders of synthesis of a glycogen (up to forming of a diabetes mellitus);
  • thrombocytosis;
  • myocardium dystrophy;
  • giperprotrombinemiya;
  • neutrophylic leukocytosis;
  • diarrhea;
  • erythrocytopenia;
  • dysbacteriosis in an oral cavity;
  • hemolysis of erythrocytes (with insufficiency erythrocyte glyukozo-6-fosfatdegidrogenazy);
  • damage mucous digestive tract;
  • vomiting;
  • frustration of the glomerular renal device;
  • heartburn;
  • crystalluria;
  • emergence of oxalic, cistone and/or uratny concrements in urinary tract and kidneys;
  • disturbances in an exchange of copper, zinc;
  • renal failure.

Tablets Efizol, application instruction

The application instruction of Efizol assumes use of rassasyvayemy tablets by the patients who reached 4-year age. The recommended single dosage equals to the 1st tablet, rassasyvayemy each 2-3 hours (but it is no more than 8-10 pieces at 24 o'clock). Chewing of tablets is not allowed. After a rassasyvaniye of one tablet to the patient recommend to refrain for half an hour from food and drink.

After disappearance of symptomatology of a disease state, for fixing of effect, treatment should be continued for 24-48 hours, but to limit the general course of therapy at most seven days (because of danger of forming of dysbacteriosis).


At a single dose of excessive dosages of Efizol observed emergence of the above described by-effects (including nausea/vomiting and diarrhea).

At long reception of high dosages of ascorbic acid suppression in a pancreas of normal operation of its insulyarny device is possible that demands a constant control over its functionality. Also high doses of vitamin C can become the reason of sedimentation of oxalic concrements, because of changes in process of acetylation of excretion kidneys of uric and ascorbic acids.

Treatment of all negative effects of overdose has to correspond to observed symptoms.


At parallel use of detergents, including many toothpastes, decrease in antibacterial efficiency of a dekvalin of chloride is observed.

Absorption of ascorbic acid decreases at its combined reception with alkaline drink, vegetable or fruit juice, and also oral contraceptives.

Oral administration of ascorbic acid leads to increase of absorption of tetracycline, iron and penicillin, and also increases absorption in aluminum intestines that should be considered in case of a concomitant use of aluminum-bearing antacids.

Vitamin C reduces effect of indirect anticoagulants and Heparin, and in case of parallel use of salicylates increases risk of forming of a crystalluria.

Combined use of Deferoxaminum and ascorbic acid leads to strengthening of fabric toxicity of iron, in particular in a cardiac muscle, and can become the reason of a decompensation of circulatory system. In this regard the interval between use of these drugs has to make not less than 120 minutes.

Long reception of vitamin C in big dosages reduces efficiency of therapy by neuroleptics of group of a fenotiazin, tricyclic antidepressants, breaks renal removal of a meksiletin, negatively influences a canalicular reabsorption of amphetamine, and at the patients passing treatment for alcoholism and accepting Disulfiramum Disulfiramum - alcoholic reaction slows down forming.

Ascorbic acid increases cumulative clearance of alcohol.

Medicines of group of quinolines, salicylates, Calcii chloridum and glucocorticoids, in case of their prolonged use, reduce the content of ascorbic acid in an organism.

At Efizol and Kayeksalat's parallel use (the drug used for therapy of a hyperpotassemia) there is a probability of emergence of serious necrotic defeats of integuments and mucous membranes (in particular concerning bodies of a gastrointestinal tract).

Terms of sale

Efizol's acquisition does not demand existence of the recipe.

Storage conditions

Tablets keep all the properties at a temperature up to 25 ºС.

Period of validity

It is possible to use Efizol for 3 years from the moment of its production.

Special instructions

As in drug Efizol is absent the anesthetizing ingredient, its use at severe pain in a throat is inexpedient.

In case of identification of the main clinical symptomatology of generalization of an infection the patient should see immediately a doctor for the solution of a question of parallel purpose of a system antibioticotherapia.

At detection of any negative phenomena connected with Efizol's reception, therapy should be stopped immediately.

The combined use with the other means used for topical treatment needs to be carried out with care and under control of medical personnel.

Processes of absorption of vitamin C can be broken at enterita, diskineziya and an akhiliya.

Efizol's appointment demands care at the diagnosed insufficiency glyukozo-6-fosfatdegidrogenazy, and also earlier observed diseases of kidneys.

Reception of ascorbic acid can negatively influence indicators of the conducted laboratory researches, including determination of plasma content of bilirubin, glucose, a lactate dehydrogenase and transaminases.

Long reception of ascorbic acid in dosages is higher than 1 gram in days that considerably exceeds the recommended Efizol's doses, demands carrying out monitoring of activity of a pancreas, renal function and indicators of arterial pressure.

In case of Efizol's use by patients with an urolithiasis it is necessary not to allow reception of ascorbic acid in dosages higher than 1 gram at 24 o'clock as it can become the reason of forming of oxalic stones.

Patients with a galactosemia should apply Efizol with care.

Careful purpose of drug is demanded by patients with sideroblastny anemia, hemochromatosis, a polycythemia, a thalassemia and leukemia, because of increase by ascorbic acid of absorption of iron. Patients in whose organism the increased concentration of iron is observed should adhere to the dosing mode strictly.

Patients with high rates of coagulability of blood have to accept Efizol in the minimum doses.


There is a set of analogs of drug Efizol, the most known of which are:


  • Efizol of a tablet for suction No. 20 the Antibiotic (Bulgaria)


  • Efizol No. 20 of the tab. for рассас.Balkanpharma-Dupnitza AD (Bulgaria)
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Section: For an oral cavity
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Education: Graduated from the Vinnytsia national medical university of N. I. Pirogov, pharmaceutical faculty, the higher pharmaceutical education – the specialty "Pharmacist".

Experience: Work in Koneks and Bios-Media pharmacy chains as "Druggist". Work as "Pharmacist" in Avicenna pharmacy chain of the city of Vinnytsia.

PAY ATTENTION! Information on drugs on the website is help generalizing, collected from public sources and can form the basis for making decision on use of medicines it is not aware of treatment. Before medicine use Efizol surely consult with the attending physician.