Эгилок Drug photo

The description is actual on 28.04.2014

  • Latin name: Egilok, Egilok S, Egilok Retard
  • ATH code: C07AB02
  • Active ingredient: Metoprolola tartrate (Metoprolol tartat) / Metoprolol sutskinat (Metoprolol succinate)
  • Producer: Egis, Hungary, India


Tablets on 25, 50, 100, 200 mg.

Egilok, Egilok Retard is the share of one tablet to 25, 50, 100 mg of active agent (metoprolol tartrate) respectively.

On one tablet Egilok With, active agent (metoprolol succinate) is necessary 23.75, 47.5, 95, 190 mg respectively.

Excipients for Egilok, Egilok Retard: povidone, sodium carboxymethylstarch, magnesium stearate, cellulose microcrystallic, colloid anhydrous silicon dioxide.

Excipients for Egilok With: ethyl cellulose, microcrystallic cellulose, corn starch, metaltsellyuloza, glitserol, magnesium stearate.

Release form

10 pieces in everyone for 25 mg, 50 mg, 100 mg, 200 mg of tablets are packed into a cardboard pack on 1, 2 and 3 blisters.

It is packed into a bottle from dark glass: 30 and 60 pieces for 25 mg, 50 mg and 100 mg of tablets.


Round biconvex tablets of white or almost white color. Inodorous. Volume: 25 mg, 50 mg, 100 mg.

  • On a tablet Egilok of 25 mg on one party the crosswise dividing line with a double bevel, on other party E435 engraving.
  • On a tablet Egilok of 50 mg on one party of risk, on other party E434 engraving.
  • On a tablet Egilok of 100 mg on one party of risk, on other party E432 engraving.

Egilok Retard

White biconvex tablets of a round form, on both parties of risk. Volume is 50 mg and 100 mg.

Egilok With

Biconvex tablets in a white film cover of an oval form. On both parties of risk. Volume: 25 mg, 50 mg, 100 mg, 200 mg.

Pharmacological action

Develops hypotensive, antiarrhytmic, anti-anginal and beta1-adrenoceptor blocking stimulation. Causes fast lowering of reductions in a cardiac muscle.

In case of sinus tachycardia against a hyperthyroidism and functional heart troubles, and also at atrial fibrillation and supraventricular tachycardia medicine is capable to slow down considerably ChSS up to recovery of a sinoatrial rate.

Unlike non-selective beta adrenoblockers the effect of a metoprolol on a carbohydrate metabolism and products of insulin is less considerable.

Pharmacodynamics and pharmacokinetics

Drug has the high speed of assimilation in a gastrointestinal tract. Within 1.5-2 hours after reception Cmax in a blood plasma is reached. Under the influence of active ingredient a superactivity of sympathetic system in relation to heart is suppressed. From what tablets Egilok at the regular use cause decrease in level of cholesterol in blood serum. Bioavailability of drug increases by 30-40% if to accept metoprolol together with food.

The impaired renal function and a liver practically does not exert impact on removal and assimilation of active ingredient. However at the expressed abnormal liver function (cirrhosis, the imposed porto-caval shunt) bioavailability considerably increases, and at a chronic renal failure the risk of emergence of undesirable side effects increases. At advanced age the medicine pharmacokinetics does not give in to essential changes.

After the use, medicine passes full degree of an absorbiruyemost. Egilok has weak linkng with proteins in a blood plasma (no more than 10%). Drug is removed from an organism mainly in the form of metabolites, only 5% are brought by kidneys.

Indications to Egilok's use

  • preventive prevention of attacks of migraine;
  • the increased arterial pressure;
  • the broken functional cordial activity;
  • stenocardia;
  • the broken cordial rhythm (supraventricular tachycardia and bradycardia at ventricular extrasystoles and a febrilyation of auricles);
  • myocardial infarction.

Indications to use of tablets also extend to people is more senior than 60 years.


  • SSSU;
  • cardiogenic shock;
  • the expressed bradycardia (less than 50 beats per minute);
  • lactic period;
  • concomitant use of MAO of inhibitors;
  • age till 18 flyings;
  • hypersensitivity to drug components in particular, or to beta adrenoblockers in general;
  • sinuatrial blockade;
  • strongly broken peripheric circulation;
  • bronchial asthma in a severe form;
  • AV — blockade 2 or 3 degrees.


  • In relation to TsNS: the raised threshold of fatigue it is (very frequent), headaches and dizziness (frequent); infrequently – spasms, the weakened attention, a depression, the strengthened heart failure, nightmares; seldom – nervous irritability, an alarming state, sexual dysfunction, hallucinations, memory disturbance.
  • In relation to sense bodys (seldom): deterioration in sight.
  • In relation to the alimentary system (seldom): abdominal pains, diarrhea, locks, dryness in a mucous membrane in an oral cavity.
  • In relation to respiratory system: an asthma at a physical tension (often), rhinitis (seldom).
  • In relation to integuments (not often): rash, sweating strengthening.

Application instruction of Egilok

Pill is taken orally, washed down with a small amount of water. Reception is allowed both during food it (is recommended), and on a hungry stomach.

The instruction on Egilok Retard and Egilok: the dose is divided in two steps in days, in the morning and in the evening.

The instruction on Egilok With: accept 1 time a day, in the morning.

How to accept (the final size of a dose and the number of receptions) medicine, is defined by the doctor individually. Maximum dose of 200 mg. At an impaired renal function and at advanced age redistribution of volumes of the consumed medicine is not required.

  • Heart failure at compensation: 25 mg a day.
  • Hyperthyroidism: 50-200 mg a day.
  • Arrhythmia: 50-200 mg a day.
  • Stenocardia: 50 mg a day.
  • Attacks of migraine (prevention): 100-200 mg a day.
  • Tachycardia: 50-200 mg a day.
  • Myocardial infarction (secondary prevention): 200 mg a day.


Use of drug, excessive and uncoordinated to the doctor, attracts to overdose which most explicit symptom, reaction from cardiovascular system is: pulse delay, heart failure. In certain cases, when using medicine by persons 18 years are younger negative reaction from TsNS is also possible: fatigue increase, developing of spasms, excess sweating, occurrence of fatigue.

General symptoms: an apnoea, the broken consciousness, a tremor, a bronchospasm, vomiting, a hyperpotassemia or a hyperglycemia, deterioration in renal activity, an asystolia, noticeable decrease in the ABP.

In case of overdose within 20-120 minutes arises one or several of the above described symptoms depending on features of an organism. High concentration of a metoprolol in an organism depending on character of symptoms is eliminated with a gastric lavage, symptomatic therapy, purpose of adsorbents, Atropini sulfas, gluconate, dopamine, Norepinephrinum.

Use of medicine Egilok with other medicamentous drugs

The list of the forbidden drugs to simultaneous use with Egilok is wide. Therefore, it is necessary to combine with special attentiveness this medicine with third-party medicines.

When mixing with verapamil it is capable to cause a cardiac standstill.

When mixing with beta adrenoblockers (estrogen, theophylline, indometacin) hypotensive property of a metoprolol decreases.

When mixing with ethanol the forcing impact on TsNS amplifies.

When mixing with peroral hypoglycemic drugs and insulin the probability emergence of a hypoglycemia increases.

When mixing with barbiturates (pentobarbital) under the influence of induction of enzymes the metabolism of a metoprolol accelerates.

Terms of sale

Egilok is released according to the recipe of the doctor.

Storage conditions

Egilok, Egilok Retard is stored at a temperature from 15 to 25 degrees.

Egilok With is stored at a temperature up to 30 degrees.

Period of validity

Egilok Retard, Egilok: 5 years.

Egilok With: 3 years.

Egilok's analogs

At a cardioselective blocker of β-adrenoceptors ((((((((((MNN: Metoprolol) analogs, similar in the made impact on an organism, are provided. Treat them: Betalok, Vazokardin, Corvitolum, Lidalok, Metozok, Metokard, Metolol, Emzok, Metoprolol. However it is necessary to understand, analogs of medicine can not always replace initially appointed recipe fully. Therefore, when replacing medicine by similar drug, surely consult with the cardiologist.

Concor or Egilok — what is better?

The exact answer can be given only at individual inspection. However in general, Concor has slightly less side effects in comparison with Egilok, and his use at low pulse is more admissible. Egilok has stronger medicamentous effect in comparison with Concor.

Egilok and alcohol

Interaction of medicine with alcohol-containing substances attracts to sharp decrease in the ABP that in turn can lead to a brain hypoxia. So, are possible: weakness, dizziness, loss of consciousness. In case of non-rendering of medical care and at strong concentration in an organism of a metoprolol and alcohol there is exhaustion of energy resources in a brain that can lead to tragic effects.


  • Egilok of 25 mg No. 60 tabletkiegis
  • Egilok of 50 mg No. 60 tabletkiegis
  • Egilok of 100 mg No. 30 tabletkiegis
  • Egilok Retard of 100 mg No. 10 tabletkiegis
  • Egilok of 100 mg No. 60 tabletkiegis

Drugstore of IFC

  • Egilok With tbl pro-longum. actions p/pl/o 50 mg No. 30, Egisvengriya
  • Egilok tbl 100 mg No. 60, Egisvengriya
  • Egilok tbl 50 mg No. 60, Egisvengriya
  • Egilok tbl 25 mg No. 60, Egisvengriya
  • Egilok tbl 100 mg No. 30, Egisvengriya
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  • Egilokegis (Hungary)
  • Egilokegis (Hungary)
  • Egilok retard tablets 100 of mg No. 30egis (Hungary/France)
  • Egilokegis (Hungary)
  • Egilok retard tablets 50 of mg No. 30egis (Hungary/France)


  • Egilok retard tab. of 100 mg No. 30egis
  • Egilok retard tab. of 100 mg No. 30egis
  • Egilok retard tab. of 100 mg No. 30egis
  • Egilok retard tab. of 100 mg No. 30egis
  • Egilok retard tab. of 100 mg No. 30egis


  • Egilok of 100 mg No. 30 tabl.p.o.retardegis Pharmaceutical plant of joint stock company (Hungary)
  • Egilok of 100 mg No. 60 of the tab. Egis Pharmaceutical plant of joint stock company (Hungary)
  • Egilok of 50 mg No. 60 of the tab. Egis Pharmaceutical plant of joint stock company (Hungary)
  • Egilok of 50 mg No. 30 tabl.p.o.retardegis Pharmaceutical plant of joint stock company (Hungary)
  • Egilok of 25 mg No. 60 of the tab. Egis Pharmaceutical plant of joint stock company (Hungary)
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Section: Cardiovascular
PAY ATTENTION! Information on drugs on the website is help generalizing, collected from public sources and can form the basis for making decision on use of medicines it is not aware of treatment. Before medicine use Egilok surely consult with the attending physician.