Ekoklav

Экоклав Drug photo

The description is actual on 04.07.2016

  • Latin name: Ecoclav
  • ATH code: J01CR02
  • Active ingredient: Amoxicillin + Clavulanic acid (Amoxicillin + Clavulanic acid)
  • Producer: AVVA-RUS, STI-MED-SORB (Russia)

Structure

Amoxicillin trihydrate + potassium clavulanate, aspartame, lactulose, silicon dioxide, xanthane gum, krestoviden, monohydrate of citric acid, citrate sodium dihydrate, talc, sodium benzoate, Mannitolum, orange fragrance.

Release form

  • Tablets of Ekoklav biconvex an oval form of white color in a film cover in strip planimetric packagings on 5, 7 pieces in a cardboard pack No., 7, 15, 21.
  • Powder of Ekoklav for intake (in the form of suspension) in a bottle of 25 g with a dosing spoon.

Pharmacological action

Antibacterial.

Pharmacodynamics and pharmacokinetics

Pharmacodynamics

The antibiotic of Ekoklav possesses broad bactericidal action. The amoxicillin which is its part oppresses process of production of protein of a cell wall of the bacteria sensitive to it.

Clavulanic acid is related to bacterial lactamelements and creates with them stable connection, preventing amoxicillin biodegradation by beta lactamelements, at the same time, bactericidal activity of an antibiotic remains. Drug is active concerning a big number of gram-positive and gram-negative aerobic and anaerobic microorganisms.

Pharmacokinetics

Ekoklav, after its intake, are quickly soaked up from a gastrointestinal tract. Tmax of drug makes about one hour. Both components Ekoklava are well distributed in various bodies and fabrics, quickly creating required therapeutic concentration. Extent of communication with blood proteins moderate: 18% amoxicillin and 25% clavulanic acid. The metabolism occurs in a liver, is removed through kidneys and partially, through intestines.

Indications to use

The diseases of infectious and inflammatory genesis of various bodies and systems of an organism caused by the activators sensitive to Ekoklavu:

  • infections of ENT organs and lower respiratory tracts;
  • infections of bodies of a small pelvis, diseases of urinogenital system;
  • infections of soft tissues and skin;
  • infections of joints and bones.

Contraindications

High sensitivity to drug, an infectious mononucleosis, liver diseases, a chronic renal failure, age till 12 flyings or weight is up to 40 kg (for medicine in the form of tablets), pregnancy.

Side effects

Drug is well transferred by most of patients. Side effects mainly slight also have the passing character.

Are shown: nausea, diarrhea, vomiting, a liver failure (at long therapy), gastritis, hepatitis, colitis; thrombocytopenia, leukopenia, hemolitic anemia, agranulocytosis, thrombocytosis, eosinophilia; dizziness, change of behavior, headache, hyperactivity, alarm; local allergic reactions; nephrite, a hamaturia, candidiasis is possible.

Ekoklav, application instruction (Way and dosage)

The dosage Ekoklava is defined individually and depends on the weight of the patient, his age, localization and weight of a course of infectious process, sensitivity of microorganisms.

To adults and children after 12 flyings

The maximum daily dose for adults: clavulanic acid — 600 mg; amoxicillin — 6 g of Ekoklav for children are more senior than 12 years or is appointed weighing more than 40 kg in the dosage similar to the adult. Course of therapy of 5 — 14 days.

Tablets

The diseases proceeding in an easy or medium-weight form — on 1 tablet (250+125 mg) 3 times a day or on one tablet (500+125 mg) twice a day.

The diseases proceeding in a severe form or at infectious diseases of the lower respiratory tracts — to accept on one tablet (875+125 mg) twice a day or on one tablet (500 mg +125 mg) three times a day.

Suspension

Drug can be accepted also in the form of suspension in a similar dosage.

How to part Ekoklav

Suspension from powder prepares just before use. It is previously necessary powder in a bottle well to stir up, then, adding the boiled water which is a little cooled to room temperature, to mix before receiving homogeneous suspension. For dosing of suspension it is necessary to use a dosing bilateral spoon, rinsing it water after each use.

The application instruction of suspension of Ekoklav for children

About 3 months: 30 mg of amoxicillin on 1 kg of weight a day for 2 times.

Is more senior than 3 months: 20-40 mg on 1 kg a day for 3 times.

Overdose

At long administration of drug in the doses exceeding therapeutic doses disturbances of electrolytic balance and work of a gastrointestinal tract are possible.

Interaction

It is impossible to accept Ekoklav along with Probenetsid. Purgatives, antacids and a glycosamine reduce and slow down amoxicillin absorption process; ascorbic acid increases absorption. NVPS, diuretics, phenylbutazone and other HP which are slowing down canalicular secretion increase concentration of amoxicillin. Drug reduces efficiency of action of oral contraceptives.

Terms of sale

According to the recipe.

Storage conditions

At a temperature up to 25 °C. Not to freeze, store ready unused suspension at a temperature up to 8 °C.

Period of validity

2 years.

Analogs

Augmentin, Amoxiclav, Arlette, Medoklav, Rapiklav, Baktoklav, Panklav, Flemoklav and other drugs.

About Ekoklava

About drug in most cases positive. Ekoklav it is appointed at many infectious and inflammatory diseases and possesses high performance.

  • "… Ached with bronchitis. Appointed Ekoklav. Quickly felt improvement, dysbacteriosis was not, a good and safe antibiotic";
  • "… The child has an otitis, the Doctor appointed suspension for children of Ekoklav. In 4 days the child of anything did not complain any more, temperature fell down, and we went to a garden".

Zdravzona

  • Ekoklav 500 mg +125mg No. 15 of a tabletkiavv Rus of joint stock company
  • Ekoklav 875 mg +125mg No. 14 of a tabletkiavv Rus of joint stock company
  • Ekoklav powder for mg suspension 125 +31,25mg/5ml 25 g No. 1 of a flakonavv Rus of joint stock company
  • Ekoklav powder for mg suspension 250 +62,5mg/5ml 25 g No. 1 of a flakonavv Rus of joint stock company
  • Ekoklav 250 mg +125mg No. 15 of a tabletkiavv Rus of joint stock company

Drugstore of IFC

  • Ekoklav tbl p/pl/o 875 mg +125mg No. 14 *, Oaorossiya AVVA RUS
  • Ekoklav tbl p/pl/o 500 mg +125mg No. 15 *, Oaorossiya AVVA RUS
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Section: Antibiotics
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Education: Graduated from Sverdlovsk medical school (1968 - 1971) as "Paramedic". Graduated from the Donetsk medical institute (1975 - 1981) as "An epidemiologist, a hygienist". Passed postgraduate study in the Central scientific research institute of epidemiology Moscow (1986 - 1989). An academic degree – the candidate of medical sciences (degree is awarded in 1989, protection – the Central scientific research institute of epidemiology Moscow). Numerous advanced training courses are studied in epidemiology and infectious diseases.

Experience: Work as the manager of department of disinfection and sterilization of 1981 - 1992. Work as the manager of department of especially dangerous infections of 1992 - 2010. Teaching activity at Medical institute 2010 - 2013.

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