Etaperazin

Этаперазин Drug photo

The description is actual on 12.01.2015

  • Latin name: Etaperazin
  • ATH code: N05AB03
  • Active ingredient: Perfenazinum (Perphenazine)
  • Producer: TATHIMFARMPREPARATY (Russia)

Structure

Etaperazin contains Perfenazinum.

Release form

Is on sale in coated tablets.

Pharmacological action

Drug is antipsychotic. It possesses sedative and antiemetic action.

Pharmacodynamics and pharmacokinetics

Drug influences TsNS. This neuroleptic which possesses a broad spectrum of activity. It has antipsychotic, antiemetic and kataleptogenny effect. Besides, medicine possesses alpha and adrenolytic activity. Anticholinergic and sedative action is shown in weak or moderate degree. The hypotensive and muscular weakening effect are poorly expressed. Antipsychotic action is combined with stimulating.

Drug is also characterized by selective influence on deficiental symptomatology. Considerable extrapyramidal disturbances are possible.

Etaperazin is perfectly absorbed from a digestive tract. Considerable fluctuations of the maximum concentration in plasma are possible. Strong communication with proteins of plasma. Means is intensively split, mainly in a liver. It is excreted through kidneys and with bile.

Indications to Etaperazin's use

Indications to Etaperazin's use the following:

Contraindications

The following contraindications to use of this means are known: the progressing general diseases of a head and spinal cord, cirrhosis, hemolitic jaundice, hemopoiesis disturbances, thromboembolic diseases, pregnancy, to feeding by a breast, hepatitis, nephrite, a myxedema, dekompensirovanny heart disease, hypersensitivity to active agent, late stages of a bronchoectatic disease.

Side effects

At use of this means extrapyramidal frustration, and also allergic and vascular reactions are possible.

Application instruction of Etaperazin (Way and dosage)

Initial dosage of drug – 0,012 g. The application instruction of Etaperazin reports that it is possible to increase a daily dosage to 0,06 g, and for some patients and to 0,12 — 0,18 g. The dose in 0,002 — 0,004 g is appointed as antiemetic in obstetric, therapeutic and surgical practice. The application instruction of Etaperazin recommends to accept means 3-4 times every day.

Overdose

When using drug in the raised doses emergence of acute antipsychotic symptoms is possible. In such cases temperature quite often increases. At difficult situations disturbance of consciousness can be observed, besides, the coma is possible.

Administration of drug should be stopped immediately. Intravenous administration of Diazepam, nootropic means, solution of a dextrose, vitamins of group B and C is shown. Symptomatic treatment.

Interaction

Oppression of nervous and respiratory systems amplifies at a combination to the drugs depressing a nervous system and also to etanolsoderzhashchy means and ethanol.

The combination to the drugs provoking extrapyramidal reactions increases quantity and frequency of extrapyramidal disturbances. Fluoxetine can also cause extrapyramidal symptoms and dystonia.

Anticonvulsant drugs can reduce a threshold of convulsive readiness, and drugs for treatment of a hyperthyroidism, in turn, increase probability of emergence of an agranulocytosis.

Interaction with the means provoking arterial hypotension can cause orthostatic hypotension.

The combination to drugs which possess anticholinergic action can lead to increase of anticholinergic influence, and the antipsychotic effect of a neuroleptic at the same time can decrease.

The concomitant use of Etaperazin with MAO inhibitors, tricyclic antidepressants and Maprotilinum increases probability of development of ZNS. And the combination to antacids, salts of lithium and protivoparkinsonichesky drugs interferes with absorption of fenotiazin.

Interaction with amphetamines, the Clonidine, Epinephrinum, the Levodopa and Guanetidin can reduce their effect.

The combination to Ephedrine can weaken its vasoconstrictive action.

Terms of sale

In drugstores this means is on sale only according to the recipe.

Storage conditions

To store in the dark place.

Period of validity

Medicine period of validity – 3 years.

Etaperazin's analogs

Coincidence on the ATH code of the 4th level:

Etaperazin's analogs practically do not meet. Drug can be replaced with Perfenazinum, and also Fenotiazin's derivatives.

About Etaperazin

About Etaperazin at forums it is possible to meet the most different. Generally people write that drug helps. However there are messages and on side effects. Especially often write about drowsiness. According to reviews it is possible to draw a conclusion that medicine helps at the correct statement of the diagnosis and competently developed scheme of treatment.

Zdravzona

  • Etaperazin of 4 mg No. 50 of a tabletkitatkhimfarmpreparata of joint stock company
  • Etaperazin of 10 mg No. 50 of a tabletkitatkhimfarmpreparata of joint stock company

Drugstore of IFC

  • Etaperazin tbl p / about 10 mg No. 50 **, Tatkhimfarmpreparata (Kazan) Russia
  • Etaperazin tbl p / about 4 mg No. 50 *, Tatkhimfarmpreparata (Kazan) Russia
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Section: For a nervous system
PAY ATTENTION! Information on drugs on the website is help generalizing, collected from public sources and can form the basis for making decision on use of medicines it is not aware of treatment. Before medicine use Etaperazin surely consult with the attending physician.