Etopozid

Этопозид Drug photo

The description is actual on 22.10.2015

  • Latin name: Etoposide
  • ATH code: L01CB01
  • Active ingredient: Etopozid (Etoposide)
  • Producer: Okasa Pharma (India), Jiangsu Hengrui Medicine Co. (China)

Structure

Drug contains etopozid as active agent.

Additional components of solution for injections: polysorbate-80, ethanol anhydrous, citric anhydrous acid, macrogoal 400.

Release form

Let out solution for injections, a concentrate for injection solution and a capsule Etopozid.

Pharmacological action

Antineoplastic means.

Pharmacodynamics and pharmacokinetics

Drug Etopozid inhibits DNA topoisomerase, breaking its functions and structure. Besides, means oppresses processes of a cellular cycle.

Medicine can also work as cytotoxic means, but only at high doses.

Extent of communication of an etopozid with proteins of plasma after introduction – 99%. Active agent badly gets into cerebrospinal fluid.

Semi-removal time – 8,1 h. About a half of drug is excreted with urine in an invariable look.

Indications to use

Indications on use of medicine following:

  • small-celled lung cancer;
  • acute miyelomonotsitarny and miyelotsitarny leukosis (making the combined treatment);
  • germinogenny carcinoma of a small egg;
  • palliative therapy of not small-celled lung cancer;
  • induction therapy of a nekhodzhkinsky lymphoma;
  • placental choriocarcinoma;
  • Hodzhkin's illness;
  • acute leukoses.

Contraindications

Use at pregnancy and breastfeeding, and also aged till 2 flyings is contraindicated. Besides, it is impossible to use drug at:

  • hypersensitivity to its components;
  • dysfunctions of a liver and kidneys;
  • acute infections;
  • the expressed miyelodepressiya.

With care medicine is used in case of the surrounding herpes, disturbances of a cordial rhythm, diseases of TsNS, chicken pox, infectious defeats mucous, an alcoholism, the increased risk of a myocardial infarction, therapy of oncological diseases at children.

During a course of use of medicine it is desirable to refrain from the types of activity demanding concentration of attention: driving of transport, control of difficult mechanisms and so forth.

Side effects

In case of the combined treatment the frequency and weight of negative reactions increase.

Manifestation of side reactions often depends on a dose of drug and the scheme of use. Dozozavisimy undesirable manifestations: leukopenia and thrombocytopenia. Also following side effects are possible:

If at patients anaphylactic reactions are observed, medicine it is necessary to cancel and appoint symptomatic therapy by angiotonic agents, antihistamines, corticosteroids or plasma substitutes. Similar side reactions were most often observed at children to whom the drug was administered in concentration, above the recommended norm.

Application instruction of Etopozid (Way and dosage)

For those to whom appointed intravenously kapelno Etopozid the application instruction reports that it is necessary to administer the drug on 50–150 mg/sq.m. The course of treatment lasts 1-3 days. Use is repeated in 3 weeks.

The dosage of capsules is defined by the specialist in an individual order with side reactions and contraindications. It depends on the course of a disease and the overall clinical picture.

Overdose

Overdose can lead to a heavy mukozit, oppression of function of marrow, a lethal outcome. Besides, there are messages on heavy hepatotoxic reactions and a metabolic acidosis. The antidote is unknown. At overdose therapy symptomatic.

Interaction

Drug cannot be dissolved with buffered solutions with acidity level higher than 8 as at the same time the undesirable deposit can appear. Besides, means should not be mixed with other drugs before introduction.

At Etopozid's combination to other anti-neoplastic HP the secondary acute leukosis can develop. Also there are messages on a tumor lysis syndrome (including with a lethal outcome) at those who received drug along with other chemotherapeutic drugs.

Terms of sale

It is possible to buy Etopozid only according to the recipe of the doctor.

Storage conditions

It is necessary to store this means at the room temperature.

Period of validity

Medicine period of validity in packaging – 3 years. After opening solution for infusions can be stored only within a day at the room temperature.

Etopozid's analogs

The following analogs of Etopozid are known:

  • Vepezid;
  • Fitozid;
  • Etopozid Ebeve;
  • Etopozid-Mili;
  • Lastet;
  • Etozid;
  • Etopoz;
  • Etopozid-Lens;
  • Etopozid-Teva.

Above and above the listed medicines have to be accepted under control of the doctor.

About Etopozida

About Etopozida demonstrate that quite often at reception of means such undesirable reactions as increase of level of bilirubin, and also change of level of hemoglobin and erythrocytes appear. All patients transfer chemotherapy differently. One note that the first courses are painless, and others complain of nausea, lack of appetite, vomiting.

Zdravzona

  • Etopozid-Ebev a concentrate for solution 20mgml 5 of ml No. 1 flakonebewe pharma
  • Etopozid-Teva a concentrate for solution 20mgml 5 of ml No. 1 flakonteva Pharmaceutical
  • Etopozid-LENS 20mg/ml 5 ml a concentrate for solution No. 1 flakonlens-Farm Ltd company
  • Etopozid-Ebev a concentrate for solution 20mgml 20 of ml No. 1 flakonebewe pharma
  • Etopozid-Teva a concentrate for solution 20mgml 10 of ml No. 1 flakonteva Pharmaceutical

Drugstore of IFC

  • Etopozid solution for inf konts. 200 mg 10 ml No. 1, Ebeweavstriya
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Apteka24

  • Etopozidebewe Pharma (Austria)
  • Etopozidabic (Israel)

Paniapteka

  • Etopozid 100mg/5ml
Section: Antineoplastic
PAY ATTENTION! Information on drugs on the website is help generalizing, collected from public sources and can form the basis for making decision on use of medicines it is not aware of treatment. Before medicine use Etopozid surely consult with the attending physician.